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Zinc in PDB 7av2: LTA4 Hydrolase in Complex with FRAGMENT1Enzymatic activity of LTA4 Hydrolase in Complex with FRAGMENT1
All present enzymatic activity of LTA4 Hydrolase in Complex with FRAGMENT1:
3.3.2.6; Protein crystallography data
The structure of LTA4 Hydrolase in Complex with FRAGMENT1, PDB code: 7av2
was solved by
H.Srinivas,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7av2:
The structure of LTA4 Hydrolase in Complex with FRAGMENT1 also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the LTA4 Hydrolase in Complex with FRAGMENT1
(pdb code 7av2). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the LTA4 Hydrolase in Complex with FRAGMENT1, PDB code: 7av2: Zinc binding site 1 out of 1 in 7av2Go back to![]() ![]()
Zinc binding site 1 out
of 1 in the LTA4 Hydrolase in Complex with FRAGMENT1
![]() Mono view ![]() Stereo pair view
Reference:
C.Markert,
G.Thoma,
H.Srinivas,
B.Bollbuck,
R.M.Luond,
W.Miltz,
R.Wal̈Chli,
R.Wolf,
J.Hinrichs,
C.Bergsdorf,
K.Azzaoui,
C.A.Penno,
K.Klein,
N.Wack,
P.Jag̈Er,
F.Hasler,
C.Beerli,
P.Loetscher,
J.Dawson,
G.Wieczorek,
S.Numao,
A.Littlewood-Evans,
T.A.Rohn.
Discovery of LYS006, A Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase. J.Med.Chem. 2021.
Page generated: Wed Mar 3 16:18:47 2021
ISSN: ISSN 0022-2623 |
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