Zinc in PDB 7av2: LTA4 Hydrolase in Complex with FRAGMENT1

Enzymatic activity of LTA4 Hydrolase in Complex with FRAGMENT1

All present enzymatic activity of LTA4 Hydrolase in Complex with FRAGMENT1:
3.3.2.6;

Protein crystallography data

The structure of LTA4 Hydrolase in Complex with FRAGMENT1, PDB code: 7av2 was solved by H.Srinivas, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 24.89 / 1.95
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 77.818, 87.025, 98.888, 90, 90, 90
R / Rfree (%) 16.1 / 20.9

Other elements in 7av2:

The structure of LTA4 Hydrolase in Complex with FRAGMENT1 also contains other interesting chemical elements:

Ytterbium (Yb) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the LTA4 Hydrolase in Complex with FRAGMENT1 (pdb code 7av2). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the LTA4 Hydrolase in Complex with FRAGMENT1, PDB code: 7av2:

Zinc binding site 1 out of 1 in 7av2

Go back to Zinc Binding Sites List in 7av2
Zinc binding site 1 out of 1 in the LTA4 Hydrolase in Complex with FRAGMENT1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of LTA4 Hydrolase in Complex with FRAGMENT1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn701

b:22.3
occ:1.00
OE1 A:GLU318 2.0 22.8 1.0
NE2 A:HIS299 2.0 14.6 1.0
NE2 A:HIS295 2.1 17.8 1.0
O A:HOH801 2.5 7.8 1.0
O A:HOH1034 2.6 21.1 1.0
CD A:GLU318 2.8 25.6 1.0
OE2 A:GLU318 2.9 20.7 1.0
CD2 A:HIS295 3.0 17.2 1.0
CE1 A:HIS299 3.0 13.9 1.0
CD2 A:HIS299 3.0 14.5 1.0
CE1 A:HIS295 3.1 16.8 1.0
CE2 A:TYR383 3.7 20.6 1.0
O A:HOH803 3.8 28.8 1.0
OH A:TYR383 4.0 19.6 1.0
CG A:HIS299 4.1 13.9 1.0
ND1 A:HIS299 4.1 15.2 1.0
CG A:HIS295 4.2 15.7 1.0
CG A:GLU318 4.2 19.3 1.0
ND1 A:HIS295 4.2 17.3 1.0
CZ A:TYR383 4.3 23.9 1.0
OE1 A:GLU271 4.4 22.1 1.0
CG2 A:THR321 4.4 15.6 1.0
CD2 A:TYR383 4.6 19.7 1.0
O A:HOH942 4.7 17.2 1.0
CB A:THR321 4.8 12.2 1.0
CD A:GLU271 4.8 24.1 1.0
OE2 A:GLU296 4.8 26.0 1.0
OE2 A:GLU271 4.8 22.3 1.0
CB A:GLU318 4.9 12.2 1.0
CA A:GLU318 5.0 11.4 1.0
OE1 A:GLU296 5.0 23.2 1.0

Reference:

C.Markert, G.Thoma, H.Srinivas, B.Bollbuck, R.M.Luond, W.Miltz, R.Wal̈Chli, R.Wolf, J.Hinrichs, C.Bergsdorf, K.Azzaoui, C.A.Penno, K.Klein, N.Wack, P.Jag̈Er, F.Hasler, C.Beerli, P.Loetscher, J.Dawson, G.Wieczorek, S.Numao, A.Littlewood-Evans, T.A.Rohn. Discovery of LYS006, A Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase. J.Med.Chem. 2021.
ISSN: ISSN 0022-2623
Page generated: Wed Mar 3 16:18:47 2021

Last articles

Zn in 7M6U
Zn in 7NNG
Zn in 7NEE
Zn in 7NEU
Zn in 7M3K
Zn in 7KWD
Zn in 7KYH
Zn in 7KNG
Zn in 7KY2
Zn in 7KYF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy