Zinc in PDB 7aoz: Atomic Structure of the Poxvirus Transcription Initiation Complex in Conformation 1

All present enzymatic activity of Atomic Structure of the Poxvirus Transcription Initiation Complex in Conformation 1:
2.7.7.6;

The structure of Atomic Structure of the Poxvirus Transcription Initiation Complex in Conformation 1 also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

The binding sites of Zinc atom in the Atomic Structure of the Poxvirus Transcription Initiation Complex in Conformation 1 (pdb code 7aoz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Atomic Structure of the Poxvirus Transcription Initiation Complex in Conformation 1, PDB code: 7aoz:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Atomic Structure of the Poxvirus Transcription Initiation Complex in Conformation 1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Atomic Structure of the Poxvirus Transcription Initiation Complex in Conformation 1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1302 b:104.0 occ:1.00 NE2 A:HIS62 2.1 80.3 1.0 SG A:CYS52 2.3 87.7 1.0 SG A:CYS59 2.3 85.6 1.0 SG A:CYS49 2.3 93.7 1.0 CE1 A:HIS62 2.9 80.3 1.0 CB A:CYS49 2.9 93.7 1.0 CD2 A:HIS62 3.2 80.3 1.0 CB A:CYS52 3.4 87.7 1.0 CB A:CYS59 3.4 85.6 1.0 N A:CYS52 3.8 87.7 1.0 ND1 A:HIS62 4.0 80.3 1.0 CA A:CYS52 4.2 87.7 1.0 CG A:HIS62 4.2 80.3 1.0 CA A:CYS49 4.4 93.7 1.0 CA A:CYS59 4.4 85.6 1.0 CA A:GLY42 4.5 88.3 1.0 CB A:THR51 4.6 84.1 1.0 N A:GLY53 4.8 92.0 1.0 C A:CYS52 4.8 87.7 1.0 N A:GLY61 4.9 81.0 1.0 C A:THR51 4.9 84.1 1.0 C A:CYS49 4.9 93.7 1.0 N A:ALA43 5.0 96.5 1.0

Zinc binding site 2 out of 4 in the Atomic Structure of the Poxvirus Transcription Initiation Complex in Conformation 1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Atomic Structure of the Poxvirus Transcription Initiation Complex in Conformation 1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1303 b:145.4 occ:1.00 SG A:CYS130 2.3 119.3 1.0 SG A:CYS135 2.3 122.9 1.0 SG A:CYS93 2.3 116.7 1.0 SG A:CYS90 2.3 113.6 1.0 CB A:CYS135 3.1 122.9 1.0 CB A:CYS130 3.3 119.3 1.0 CB A:CYS90 3.6 113.6 1.0 CB A:CYS93 3.9 116.7 1.0 N A:CYS93 3.9 116.7 1.0 CB A:HIS92 4.1 116.8 1.0 C A:HIS92 4.5 116.8 1.0 CA A:CYS93 4.5 116.7 1.0 CA A:CYS135 4.6 122.9 1.0 N A:HIS92 4.6 116.8 1.0 CB A:ASN132 4.6 118.0 1.0 O A:CYS90 4.6 113.6 1.0 CA A:HIS92 4.7 116.8 1.0 CA A:CYS130 4.7 119.3 1.0 CA A:CYS90 4.9 113.6 1.0 C A:CYS90 4.9 113.6 1.0 ND2 A:ASN132 4.9 118.0 1.0

Zinc binding site 3 out of 4 in the Atomic Structure of the Poxvirus Transcription Initiation Complex in Conformation 1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Atomic Structure of the Poxvirus Transcription Initiation Complex in Conformation 1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1201 b:95.8 occ:1.00 SG B:CYS1103 2.3 76.7 1.0 SG B:CYS1090 2.3 75.7 1.0 SG B:CYS1106 2.3 78.3 1.0 SG B:CYS1087 2.3 74.2 1.0 CB B:CYS1087 3.3 74.2 1.0 CB B:CYS1106 3.3 78.3 1.0 CB B:CYS1090 3.5 75.7 1.0 CB B:CYS1103 3.5 76.7 1.0 N B:CYS1090 3.7 75.7 1.0 N B:CYS1106 4.0 78.3 1.0 CA B:CYS1090 4.2 75.7 1.0 CA B:CYS1106 4.3 78.3 1.0 CB B:ASN1089 4.3 77.1 1.0 CG B:PRO1113 4.5 78.8 1.0 ND2 B:ASN1089 4.7 77.1 1.0 C B:ASN1089 4.7 77.1 1.0 CA B:CYS1087 4.8 74.2 1.0 CB B:ARG1105 4.8 78.3 1.0 CB B:PRO1113 4.8 78.8 1.0 C B:CYS1090 4.8 75.7 1.0 CA B:CYS1103 4.9 76.7 1.0 N B:ASN1089 4.9 77.1 1.0 N B:GLY1091 4.9 72.9 1.0 CA B:ASN1089 4.9 77.1 1.0 CG B:ASN1089 5.0 77.1 1.0

Zinc binding site 4 out of 4 in the Atomic Structure of the Poxvirus Transcription Initiation Complex in Conformation 1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Atomic Structure of the Poxvirus Transcription Initiation Complex in Conformation 1 within 5.0Å range: probe atom residue distance (Å) B Occ I:Zn801 b:177.2 occ:1.00 ND1 I:HIS328 2.1 153.2 1.0 SG I:CYS366 2.3 134.3 1.0 SG I:CYS363 2.3 135.2 1.0 SG I:CYS326 2.3 153.2 1.0 CG I:HIS328 2.8 153.2 1.0 CE1 I:HIS328 2.9 153.2 1.0 CB I:CYS363 3.0 135.2 1.0 CB I:HIS328 3.2 153.2 1.0 CB I:CYS326 3.4 153.2 1.0 CB I:CYS366 3.6 134.3 1.0 N I:CYS366 3.6 134.3 1.0 CD2 I:HIS328 3.8 153.2 1.0 NE2 I:HIS328 3.8 153.2 1.0 CA I:CYS366 4.1 134.3 1.0 N I:HIS328 4.2 153.2 1.0 CA I:HIS328 4.3 153.2 1.0 CB I:VAL365 4.4 140.9 1.0 C I:CYS366 4.5 134.3 1.0 CA I:CYS363 4.5 135.2 1.0 C I:VAL365 4.6 140.9 1.0 O I:CYS366 4.7 134.3 1.0 N I:VAL365 4.7 140.9 1.0 CD2 I:PHE353 4.7 147.5 1.0 CA I:CYS326 4.8 153.2 1.0 CA I:VAL365 4.8 140.9 1.0

C.Grimm, J.Bartuli, B.Boettcher, A.A.Szalay, U.Fischer. Structural Basis of the Complete Poxvirus Transcription Initiation Process Nat.Struct.Mol.Biol. 2021.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-021-00655-W