Zinc in PDB 7alb: Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound

All present enzymatic activity of Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound:
3.5.4.16;

The structure of Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound, PDB code: 7alb was solved by R.Ebenhoch, H.Nar, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	160.06 / 1.98
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	160.656, 116.137, 177.316, 90, 94.94, 90
R / Rfree (%)	20.6 / 22.5

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20;

Binding sites:

The binding sites of Zinc atom in the Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound (pdb code 7alb). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 20 binding sites of Zinc where determined in the Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound, PDB code: 7alb:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Zinc binding site 1 out of 20 in the Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:35.4 occ:1.00 ND1 A:HIS144 2.5 30.9 1.0 SG A:CYS141 2.5 35.2 1.0 SG A:CYS212 2.5 33.8 1.0 H7 B:QBQ302 2.9 31.5 0.0 CB A:CYS212 2.9 29.5 1.0 CG A:HIS144 3.3 29.5 1.0 CB A:CYS141 3.3 31.1 1.0 CB A:HIS144 3.4 27.7 1.0 CE1 A:HIS144 3.5 31.1 1.0 C4 B:QBQ302 3.8 25.1 1.0 H6 B:QBQ302 3.9 29.9 0.0 N A:HIS144 4.0 29.0 1.0 H3 B:QBQ302 4.1 34.0 0.0 C3 B:QBQ302 4.2 24.1 1.0 CA A:HIS144 4.3 28.3 1.0 CA A:CYS212 4.4 28.6 1.0 CD2 A:HIS144 4.5 30.3 1.0 CB A:HIS143 4.5 32.9 1.0 NE2 A:HIS144 4.6 31.6 1.0 H15 B:QBQ302 4.8 32.1 0.0 CA A:CYS141 4.8 29.8 1.0 C A:HIS143 4.8 30.6 1.0 N A:CYS212 4.9 27.7 1.0 N2 B:QBQ302 5.0 25.8 1.0

Zinc binding site 2 out of 20 in the Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn301 b:34.9 occ:1.00 ND1 B:HIS144 2.3 32.0 1.0 SG B:CYS141 2.5 30.6 1.0 SG B:CYS212 2.5 34.5 1.0 O B:HOH408 2.7 25.6 1.0 H7 C:QBQ302 2.8 39.9 0.0 CB B:CYS212 3.0 28.2 1.0 CG B:HIS144 3.1 30.6 1.0 CB B:HIS144 3.3 28.8 1.0 CE1 B:HIS144 3.3 32.2 1.0 CB B:CYS141 3.4 27.1 1.0 C4 C:QBQ302 3.7 29.9 1.0 N B:HIS144 3.9 29.2 1.0 H6 C:QBQ302 4.0 38.4 0.0 H3 C:QBQ302 4.1 39.8 0.0 CA B:HIS144 4.2 28.4 1.0 C3 C:QBQ302 4.2 29.0 1.0 CD2 B:HIS144 4.3 31.7 1.0 O B:HOH406 4.3 25.1 1.0 NE2 B:HIS144 4.3 32.4 1.0 CA B:CYS212 4.5 27.6 1.0 CB B:HIS143 4.5 30.4 1.0 C B:HIS143 4.7 30.1 1.0 H15 C:QBQ302 4.8 37.5 0.0 CA B:CYS141 4.8 26.5 1.0 N2 C:QBQ302 4.9 30.2 1.0 CA B:HIS143 5.0 29.5 1.0

Zinc binding site 3 out of 20 in the Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn301 b:30.4 occ:1.00 ND1 C:HIS144 2.3 21.8 1.0 SG C:CYS141 2.5 23.8 1.0 SG C:CYS212 2.5 27.0 1.0 H7 D:QBQ302 2.8 27.2 0.0 CB C:CYS212 3.0 24.2 1.0 CG C:HIS144 3.1 21.1 1.0 CE1 C:HIS144 3.2 22.4 1.0 CB C:CYS141 3.4 19.3 1.0 CB C:HIS144 3.4 20.2 1.0 C4 D:QBQ302 3.7 21.9 1.0 H3 D:QBQ302 4.0 26.7 0.0 N C:HIS144 4.0 21.0 1.0 H6 D:QBQ302 4.0 26.4 0.0 O D:HOH404 4.2 20.4 1.0 O C:HOH416 4.2 18.2 1.0 C3 D:QBQ302 4.2 21.4 1.0 CD2 C:HIS144 4.3 22.1 1.0 NE2 C:HIS144 4.3 23.0 1.0 CA C:HIS144 4.3 20.2 1.0 CA C:CYS212 4.4 24.1 1.0 CB C:HIS143 4.6 24.1 1.0 H15 D:QBQ302 4.7 25.4 0.0 C C:HIS143 4.8 22.2 1.0 CA C:CYS141 4.8 19.2 1.0 N2 D:QBQ302 4.9 22.1 1.0 C9 D:QBQ302 4.9 21.6 1.0 N C:CYS212 5.0 23.8 1.0

Zinc binding site 4 out of 20 in the Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn301 b:34.3 occ:1.00 ND1 D:HIS144 2.3 25.3 1.0 SG D:CYS141 2.5 27.0 1.0 SG D:CYS212 2.5 32.5 1.0 O D:HOH439 2.8 34.8 1.0 H7 E:QBQ302 2.9 36.3 0.0 CB D:CYS212 3.0 25.7 1.0 CG D:HIS144 3.1 24.2 1.0 CE1 D:HIS144 3.3 24.7 1.0 CB D:HIS144 3.3 23.2 1.0 CB D:CYS141 3.4 22.6 1.0 C4 E:QBQ302 3.8 28.0 1.0 H6 E:QBQ302 3.9 35.4 0.0 N D:HIS144 4.0 23.3 1.0 O E:HOH411 4.1 23.4 1.0 O D:HOH427 4.1 23.4 1.0 H3 E:QBQ302 4.1 35.3 0.0 CD2 D:HIS144 4.2 24.5 1.0 C3 E:QBQ302 4.2 27.6 1.0 CA D:HIS144 4.3 23.3 1.0 NE2 D:HIS144 4.3 25.5 1.0 CA D:CYS212 4.5 24.6 1.0 CB D:HIS143 4.7 26.1 1.0 C D:HIS143 4.7 24.4 1.0 H15 E:QBQ302 4.8 33.4 0.0 CA D:CYS141 4.8 21.7 1.0

Zinc binding site 5 out of 20 in the Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound within 5.0Å range: probe atom residue distance (Å) B Occ E:Zn301 b:34.8 occ:1.00 ND1 E:HIS144 2.3 25.2 1.0 SG E:CYS141 2.5 27.9 1.0 SG E:CYS212 2.5 30.7 1.0 O E:HOH428 2.8 34.2 1.0 H7 A:QBQ302 2.9 39.4 0.0 CB E:CYS212 3.0 25.9 1.0 CG E:HIS144 3.1 24.0 1.0 CB E:HIS144 3.3 22.6 1.0 CE1 E:HIS144 3.3 25.5 1.0 CB E:CYS141 3.5 22.3 1.0 C4 A:QBQ302 3.8 29.4 1.0 N E:HIS144 3.9 24.3 1.0 H6 A:QBQ302 4.0 38.3 0.0 H3 A:QBQ302 4.0 39.2 0.0 CA E:HIS144 4.2 23.1 1.0 C3 A:QBQ302 4.2 28.9 1.0 CD2 E:HIS144 4.2 25.1 1.0 O A:HOH405 4.3 22.0 1.0 NE2 E:HIS144 4.3 25.9 1.0 O E:HOH414 4.3 22.9 1.0 CA E:CYS212 4.5 24.9 1.0 CB E:HIS143 4.6 27.0 1.0 C E:HIS143 4.7 26.2 1.0 H15 A:QBQ302 4.8 37.2 0.0 CA E:CYS141 4.9 22.3 1.0 N2 A:QBQ302 5.0 29.2 1.0 CA E:HIS143 5.0 26.1 1.0 C9 A:QBQ302 5.0 29.7 1.0

Zinc binding site 6 out of 20 in the Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound within 5.0Å range: probe atom residue distance (Å) B Occ F:Zn301 b:37.6 occ:1.00 ND1 F:HIS144 2.3 27.4 1.0 SG F:CYS141 2.5 28.9 1.0 SG F:CYS212 2.5 34.5 1.0 H7 G:QBQ302 2.8 36.8 0.0 CB F:CYS212 2.9 29.4 1.0 CG F:HIS144 3.1 26.4 1.0 CE1 F:HIS144 3.3 26.9 1.0 CB F:HIS144 3.3 25.8 1.0 CB F:CYS141 3.4 25.9 1.0 C4 G:QBQ302 3.7 28.3 1.0 N F:HIS144 3.9 26.3 1.0 H6 G:QBQ302 3.9 35.9 0.0 H3 G:QBQ302 4.0 38.3 0.0 C3 G:QBQ302 4.2 27.7 1.0 O F:HOH416 4.2 22.3 1.0 CA F:HIS144 4.2 26.1 1.0 CD2 F:HIS144 4.3 26.6 1.0 NE2 F:HIS144 4.4 26.9 1.0 CA F:CYS212 4.4 28.3 1.0 CB F:HIS143 4.5 26.4 1.0 C F:HIS143 4.7 27.1 1.0 H15 G:QBQ302 4.7 36.7 0.0 CA F:CYS141 4.9 25.8 1.0 N2 G:QBQ302 4.9 28.8 1.0 C9 G:QBQ302 5.0 29.7 1.0 CA F:HIS143 5.0 26.1 1.0 N F:CYS212 5.0 28.1 1.0

Zinc binding site 7 out of 20 in the Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound within 5.0Å range: probe atom residue distance (Å) B Occ G:Zn301 b:32.4 occ:1.00 ND1 G:HIS144 2.3 24.7 1.0 SG G:CYS212 2.5 30.2 1.0 SG G:CYS141 2.5 26.4 1.0 O G:HOH440 2.6 23.2 1.0 H7 H:QBQ302 2.9 31.2 0.0 CB G:CYS212 2.9 25.8 1.0 CG G:HIS144 3.1 23.3 1.0 CB G:HIS144 3.3 22.0 1.0 CE1 G:HIS144 3.3 24.3 1.0 CB G:CYS141 3.4 21.4 1.0 C4 H:QBQ302 3.8 24.5 1.0 N G:HIS144 3.9 22.1 1.0 H3 H:QBQ302 4.0 33.3 0.0 H6 H:QBQ302 4.1 30.2 0.0 CA G:HIS144 4.2 21.7 1.0 CD2 G:HIS144 4.3 23.6 1.0 O G:HOH420 4.3 21.5 1.0 NE2 G:HIS144 4.3 24.4 1.0 C3 H:QBQ302 4.3 23.7 1.0 CA G:CYS212 4.4 23.9 1.0 CB G:HIS143 4.6 23.4 1.0 C G:HIS143 4.7 23.7 1.0 CA G:CYS141 4.8 21.1 1.0 C9 H:QBQ302 4.9 26.4 1.0 N G:CYS212 5.0 24.0 1.0

Zinc binding site 8 out of 20 in the Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound within 5.0Å range: probe atom residue distance (Å) B Occ H:Zn301 b:30.6 occ:1.00 ND1 H:HIS144 2.3 27.9 1.0 SG H:CYS141 2.5 26.8 1.0 SG H:CYS212 2.5 30.5 1.0 O H:HOH431 2.8 39.6 1.0 H7 I:QBQ302 3.0 35.3 0.0 CB H:CYS212 3.0 27.3 1.0 CG H:HIS144 3.2 25.9 1.0 CE1 H:HIS144 3.3 27.8 1.0 CB H:CYS141 3.3 21.5 1.0 CB H:HIS144 3.4 23.7 1.0 C4 I:QBQ302 3.8 27.9 1.0 N H:HIS144 3.9 24.2 1.0 H6 I:QBQ302 3.9 34.5 0.0 H3 I:QBQ302 4.1 35.4 0.0 C3 I:QBQ302 4.2 27.5 1.0 CA H:HIS144 4.3 23.2 1.0 O H:HOH415 4.3 26.1 1.0 O I:HOH407 4.3 22.7 1.0 CD2 H:HIS144 4.3 26.1 1.0 NE2 H:HIS144 4.4 27.2 1.0 CB H:HIS143 4.5 28.2 1.0 CA H:CYS212 4.5 25.3 1.0 C H:HIS143 4.7 25.9 1.0 H15 I:QBQ302 4.8 33.2 0.0 CA H:CYS141 4.8 21.1 1.0 CA H:HIS143 5.0 25.9 1.0

Zinc binding site 9 out of 20 in the Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 9 of Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound within 5.0Å range: probe atom residue distance (Å) B Occ I:Zn301 b:35.4 occ:1.00 ND1 I:HIS144 2.3 33.0 1.0 SG I:CYS141 2.5 30.9 1.0 SG I:CYS212 2.5 31.4 1.0 CB I:CYS212 3.0 27.4 1.0 H7 J:QBQ302 3.0 39.9 0.0 CG I:HIS144 3.2 31.4 1.0 CE1 I:HIS144 3.3 33.5 1.0 CB I:HIS144 3.4 28.6 1.0 CB I:CYS141 3.4 26.0 1.0 C4 J:QBQ302 3.9 30.6 1.0 N I:HIS144 3.9 28.2 1.0 H6 J:QBQ302 4.0 39.0 0.0 H3 J:QBQ302 4.1 40.4 0.0 CD2 I:HIS144 4.3 32.8 1.0 CA I:HIS144 4.3 28.1 1.0 NE2 I:HIS144 4.3 34.2 1.0 C3 J:QBQ302 4.3 30.3 1.0 CA I:CYS212 4.5 27.1 1.0 CB I:HIS143 4.5 31.6 1.0 H15 J:QBQ302 4.7 38.5 0.0 C I:HIS143 4.7 29.8 1.0 CA I:CYS141 4.8 25.8 1.0 CA I:HIS143 5.0 30.1 1.0

Zinc binding site 10 out of 20 in the Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 10 of Human Gch-Gfrp Stimulatory Complex 7-Deaza-Gtp Bound within 5.0Å range: probe atom residue distance (Å) B Occ J:Zn301 b:37.1 occ:1.00 ND1 J:HIS144 2.4 29.5 1.0 SG J:CYS141 2.5 35.8 1.0 SG J:CYS212 2.5 35.4 1.0 H7 F:QBQ302 2.8 43.9 0.0 CB J:CYS212 3.0 27.5 1.0 CG J:HIS144 3.3 29.2 1.0 CB J:CYS141 3.3 31.6 1.0 CE1 J:HIS144 3.4 29.4 1.0 CB J:HIS144 3.4 28.9 1.0 C4 F:QBQ302 3.6 35.2 1.0 H6 F:QBQ302 3.8 43.0 0.0 H3 F:QBQ302 3.9 42.8 0.0 N J:HIS144 3.9 31.2 1.0 C3 F:QBQ302 4.0 34.7 1.0 CA J:HIS144 4.3 29.8 1.0 CD2 J:HIS144 4.4 29.9 1.0 NE2 J:HIS144 4.5 30.5 1.0 H15 F:QBQ302 4.5 40.1 0.0 CA J:CYS212 4.5 27.0 1.0 CB J:HIS143 4.6 35.3 1.0 CA J:CYS141 4.7 30.7 1.0 C J:HIS143 4.7 33.1 1.0 N2 F:QBQ302 4.8 35.2 1.0 C9 F:QBQ302 4.8 34.4 1.0

R.Ebenhoch, M.Bauer, D.Reinert, A.Kersting, S.Huber, A.Schmid, I.Hinz, M.Feiler, K.Mueller, H.Nar. Using Hybrid Approaches to Study the Allosteric Regulation of Gtp Cyclohydrolase I To Be Published.