Zinc in PDB 7ako: Crystal Structure of CHK1 Kinase Domain in Complex with A Claspin Phosphopeptide

All present enzymatic activity of Crystal Structure of CHK1 Kinase Domain in Complex with A Claspin Phosphopeptide:
2.7.11.1;

The structure of Crystal Structure of CHK1 Kinase Domain in Complex with A Claspin Phosphopeptide, PDB code: 7ako was solved by M.Day, A.W.Oliver, L.H.Pearl, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	96.49 / 1.80
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	60.339, 64.454, 97.082, 90, 96.32, 90
R / Rfree (%)	19 / 23.5

The binding sites of Zinc atom in the Crystal Structure of CHK1 Kinase Domain in Complex with A Claspin Phosphopeptide (pdb code 7ako). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of CHK1 Kinase Domain in Complex with A Claspin Phosphopeptide, PDB code: 7ako:

Zinc binding site 1 out of 1 in the Crystal Structure of CHK1 Kinase Domain in Complex with A Claspin Phosphopeptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of CHK1 Kinase Domain in Complex with A Claspin Phosphopeptide within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1001 b:94.1 occ:1.00 N C:GLU938 2.1 35.5 1.0 SG C:CYS944 2.9 41.3 1.0 SG A:CYS57 3.0 30.4 1.0 CA C:GLU938 3.5 41.8 1.0 CB A:CYS57 3.6 23.0 1.0 N C:GLU939 3.7 34.9 1.0 C C:GLU938 3.9 39.7 1.0 CD2 C:LEU940 4.1 31.5 1.0 O C:HOH1103 4.1 48.9 1.0 CB C:CYS944 4.3 39.4 1.0 C C:GLU939 4.5 33.9 1.0 CB C:GLU938 4.6 44.7 1.0 CA C:CYS944 4.6 41.5 1.0 O C:GLU939 4.6 34.6 1.0 O A:LYS54 4.7 29.2 1.0 N C:LEU940 4.7 31.7 1.0 CA C:GLU939 4.7 42.9 1.0 CG A:LYS54 4.8 38.2 1.0 CG C:LEU940 4.8 33.2 1.0 CG1 A:ILE58 4.9 25.9 1.0 CA A:LYS54 4.9 30.9 1.0 CA A:CYS57 4.9 21.1 1.0 O C:GLU938 5.0 38.0 1.0 N C:CYS944 5.0 38.9 1.0

M.Day, S.Parry-Morris, J.Houghton-Gisby, A.W.Oliver, L.H.Pearl. Structural Basis For Recruitment of the CHK1 Dna Damage Kinase By the Claspin Scaffold Protein. Structure 2021.
ISSN: ISSN 0969-2126
PubMed: 33789090
DOI: 10.1016/J.STR.2021.03.007