Zinc in PDB 7adh: Three-Dimensional Structure of Isonicotinimidylated Liver Alcohol Dehydrogenase

All present enzymatic activity of Three-Dimensional Structure of Isonicotinimidylated Liver Alcohol Dehydrogenase:
1.1.1.1;

The structure of Three-Dimensional Structure of Isonicotinimidylated Liver Alcohol Dehydrogenase, PDB code: 7adh was solved by B.Plapp, H.Eklund, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	N/A / 3.20
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	177.800, 61.200, 56.500, 90.00, 104.00, 90.00
R / Rfree (%)	29 / n/a

The binding sites of Zinc atom in the Three-Dimensional Structure of Isonicotinimidylated Liver Alcohol Dehydrogenase (pdb code 7adh). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Three-Dimensional Structure of Isonicotinimidylated Liver Alcohol Dehydrogenase, PDB code: 7adh:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Three-Dimensional Structure of Isonicotinimidylated Liver Alcohol Dehydrogenase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Three-Dimensional Structure of Isonicotinimidylated Liver Alcohol Dehydrogenase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn375 b:20.0 occ:1.00 SG A:CYS46 2.1 20.0 1.0 NE2 A:HIS67 2.1 20.0 1.0 SG A:CYS174 2.2 20.0 1.0 CE1 A:HIS67 2.8 20.0 1.0 CD2 A:HIS67 3.2 20.0 1.0 CB A:CYS174 3.2 20.0 1.0 CB A:CYS46 3.3 20.0 1.0 CB A:SER48 3.5 20.0 1.0 ND1 A:HIS67 4.0 20.0 1.0 CG A:HIS67 4.2 20.0 1.0 N A:SER48 4.5 20.0 1.0 CE1 A:PHE93 4.5 20.0 1.0 CA A:SER48 4.6 20.0 1.0 CA A:CYS174 4.6 20.0 1.0 OG A:SER48 4.6 20.0 1.0 CA A:CYS46 4.6 20.0 1.0 OE2 A:GLU68 4.8 20.0 1.0

Zinc binding site 2 out of 2 in the Three-Dimensional Structure of Isonicotinimidylated Liver Alcohol Dehydrogenase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Three-Dimensional Structure of Isonicotinimidylated Liver Alcohol Dehydrogenase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn376 b:20.0 occ:1.00 SG A:CYS111 2.0 20.0 1.0 SG A:CYS100 2.0 20.0 1.0 SG A:CYS103 2.1 20.0 1.0 SG A:CYS97 2.4 20.0 1.0 CB A:CYS103 3.0 20.0 1.0 CB A:CYS111 3.3 20.0 1.0 CB A:CYS100 3.6 20.0 1.0 CA A:CYS111 3.6 20.0 1.0 CB A:CYS97 3.7 20.0 1.0 N A:CYS97 3.9 20.0 1.0 N A:LEU112 4.0 20.0 1.0 CA A:CYS103 4.1 20.0 1.0 C A:CYS111 4.1 20.0 1.0 C A:LYS99 4.2 20.0 1.0 N A:CYS103 4.2 20.0 1.0 CA A:CYS97 4.3 20.0 1.0 O A:LYS99 4.3 20.0 1.0 N A:CYS100 4.3 20.0 1.0 N A:LYS99 4.4 20.0 1.0 C A:CYS97 4.5 20.0 1.0 CA A:CYS100 4.6 20.0 1.0 N A:GLY98 4.7 20.0 1.0 CA A:LYS99 4.9 20.0 1.0 CB A:LYS113 4.9 20.0 1.0 N A:CYS111 4.9 20.0 1.0 C A:GLN96 4.9 20.0 1.0 N A:GLN96 4.9 20.0 1.0 CB A:LEU112 4.9 20.0 1.0 O A:CYS100 5.0 20.0 1.0

B.V.Plapp, H.Eklund, T.A.Jones, C.I.Branden. Three-Dimensional Structure of Isonicotinimidylated Liver Alcohol Dehydrogenase. J.Biol.Chem. V. 258 5537 1983.
ISSN: ISSN 0021-9258
PubMed: 6343388