Atomistry » Zinc » PDB 7a6u-7ae5 » 7a9e
Atomistry »
  Zinc »
    PDB 7a6u-7ae5 »
      7a9e »

Zinc in PDB 7a9e: Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Ethyl Methyl Sulfone

Enzymatic activity of Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Ethyl Methyl Sulfone

All present enzymatic activity of Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Ethyl Methyl Sulfone:
2.4.2.29;

Protein crystallography data

The structure of Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Ethyl Methyl Sulfone, PDB code: 7a9e was solved by D.Nguyen, S.You, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.85 / 1.76
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 127.998, 127.998, 115.379, 90, 90, 120
R / Rfree (%) 18.2 / 20.5

Zinc Binding Sites:

The binding sites of Zinc atom in the Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Ethyl Methyl Sulfone (pdb code 7a9e). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Ethyl Methyl Sulfone, PDB code: 7a9e:

Zinc binding site 1 out of 1 in 7a9e

Go back to Zinc Binding Sites List in 7a9e
Zinc binding site 1 out of 1 in the Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Ethyl Methyl Sulfone


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Ethyl Methyl Sulfone within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:21.5
occ:1.00
ND1 A:HIS349 2.2 20.6 1.0
SG A:CYS320 2.3 22.7 1.0
SG A:CYS323 2.3 23.5 1.0
SG A:CYS318 2.3 21.9 1.0
CE1 A:HIS349 3.0 23.2 1.0
CB A:CYS318 3.3 22.2 1.0
CG A:HIS349 3.3 22.6 1.0
CB A:CYS323 3.3 23.4 1.0
CB A:CYS320 3.3 22.4 1.0
CB A:HIS349 3.7 18.2 1.0
N A:CYS323 3.9 23.1 1.0
N A:CYS320 4.1 24.7 1.0
CA A:HIS349 4.1 18.1 1.0
NE2 A:HIS349 4.2 20.1 1.0
CA A:CYS323 4.2 23.2 1.0
CA A:CYS320 4.2 23.1 1.0
CD2 A:HIS349 4.3 18.7 1.0
O A:HIS349 4.5 20.1 1.0
CA A:CYS318 4.6 19.6 1.0
C A:CYS318 4.7 23.3 1.0
C A:CYS320 4.7 25.9 1.0
O A:CYS320 4.7 23.8 1.0
C A:HIS349 4.7 20.7 1.0
O A:CYS318 4.8 24.1 1.0
CB A:VAL322 4.8 21.4 1.0
C A:VAL322 4.9 22.9 1.0

Reference:

D.Nguyen, X.Xie, S.Jakobi, F.Terwesten, A.Metz, T.X.P.Nguyen, V.A.Palchykov, A.Heine, K.Reuter, G.Klebe. Targeting A Cryptic Pocket in A Protein-Protein Contact By Disulfide-Induced Rupture of A Homodimeric Interface Acs Chem.Biol. 2021.
ISSN: ESSN 1554-8937
DOI: 10.1021/ACSCHEMBIO.1C00296
Page generated: Tue Oct 29 16:22:59 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy