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Zinc in PDB 7a1s: Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3-Methyl-2- Oxoglutarate, and Tankyrase-2 (TNKS2) Fragment Peptide (21-Mer)

Enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3-Methyl-2- Oxoglutarate, and Tankyrase-2 (TNKS2) Fragment Peptide (21-Mer)

All present enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3-Methyl-2- Oxoglutarate, and Tankyrase-2 (TNKS2) Fragment Peptide (21-Mer):
1.14.11.30;

Protein crystallography data

The structure of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3-Methyl-2- Oxoglutarate, and Tankyrase-2 (TNKS2) Fragment Peptide (21-Mer), PDB code: 7a1s was solved by Y.Nakashima, L.Brewitz, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 74.47 / 2.01
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 86.089, 86.089, 148.417, 90, 90, 90
R / Rfree (%) 18 / 20.9

Zinc Binding Sites:

The binding sites of Zinc atom in the Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3-Methyl-2- Oxoglutarate, and Tankyrase-2 (TNKS2) Fragment Peptide (21-Mer) (pdb code 7a1s). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3-Methyl-2- Oxoglutarate, and Tankyrase-2 (TNKS2) Fragment Peptide (21-Mer), PDB code: 7a1s:

Zinc binding site 1 out of 1 in 7a1s

Go back to Zinc Binding Sites List in 7a1s
Zinc binding site 1 out of 1 in the Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3-Methyl-2- Oxoglutarate, and Tankyrase-2 (TNKS2) Fragment Peptide (21-Mer)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 3-Methyl-2- Oxoglutarate, and Tankyrase-2 (TNKS2) Fragment Peptide (21-Mer) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn610

b:37.5
occ:1.00
 O A:HOH702 1.8 67.5 1.0
OD2 A:ASP201 2.0 46.7 1.0
NE2 A:HIS279 2.1 50.9 1.0
O01 A:ROQ609 2.2 47.6 1.0
NE2 A:HIS199 2.2 48.5 1.0
O02 A:ROQ609 2.2 47.9 1.0
C01 A:ROQ609 2.9 47.9 1.0
C05 A:ROQ609 2.9 48.6 1.0
CE1 A:HIS199 3.0 44.8 1.0
CE1 A:HIS279 3.0 43.6 1.0
CG A:ASP201 3.0 38.9 1.0
HE1 A:HIS199 3.1 53.8 1.0
CD2 A:HIS279 3.1 43.8 1.0
HE1 A:HIS279 3.2 52.4 1.0
CD2 A:HIS199 3.2 45.3 1.0
HD2 A:HIS279 3.3 52.6 1.0
OD1 A:ASP201 3.4 40.2 1.0
HD2 A:HIS199 3.5 54.4 1.0
HZ2 A:TRP296 3.5 51.1 1.0
O A:HOH749 3.9 38.2 1.0
ND1 A:HIS199 4.1 45.4 1.0
HB2 B:ASN706 4.1 56.8 1.0
ND1 A:HIS279 4.1 43.5 1.0
O03 A:ROQ609 4.2 46.9 1.0
CG A:HIS279 4.2 42.1 1.0
CG A:HIS199 4.2 44.7 1.0
HD22 A:ASN205 4.3 48.0 1.0
C02 A:ROQ609 4.3 47.1 1.0
CB A:ASP201 4.4 37.6 1.0
CZ2 A:TRP296 4.4 42.6 1.0
HB2 A:ASP201 4.4 45.2 1.0
HE1 A:TRP296 4.5 47.2 1.0
H03 A:ROQ609 4.7 54.2 1.0
HD22 B:ASN706 4.7 57.7 1.0
H B:ASN706 4.7 54.1 1.0
ND2 B:ASN706 4.8 48.1 1.0
H04 A:ROQ609 4.8 57.8 1.0
HD1 A:HIS199 4.8 54.5 1.0
CG B:ASN706 4.8 47.3 1.0
HD12 A:ILE281 4.9 61.4 1.0
H01 A:ROQ609 4.9 56.5 1.0
H05 A:ROQ609 4.9 57.8 1.0
CB B:ASN706 4.9 47.3 1.0
HD1 A:HIS279 4.9 52.3 1.0
H02 A:ROQ609 4.9 54.2 1.0
HB3 A:ASP201 4.9 45.2 1.0
C04 A:ROQ609 4.9 48.1 1.0
ND2 A:ASN205 5.0 40.0 1.0
HG21 A:ILE273 5.0 43.7 1.0
HD21 A:ASN205 5.0 48.0 1.0

Reference:

Y.Nakashima, L.Brewitz, C.J.Schofield. 2-Oxoglutarate Derivatives Modulate the Catalytic Activity of Human Factor Inhibiting Hif-Alpha To Be Published.
Page generated: Tue Oct 29 16:17:16 2024

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