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Zinc in PDB 7a0b: Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Rac-Trans-3,4-Dihydroxysulfolane

Enzymatic activity of Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Rac-Trans-3,4-Dihydroxysulfolane

All present enzymatic activity of Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Rac-Trans-3,4-Dihydroxysulfolane:
2.4.2.29;

Protein crystallography data

The structure of Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Rac-Trans-3,4-Dihydroxysulfolane, PDB code: 7a0b was solved by D.Nguyen, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.90 / 1.77
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 127.86, 127.86, 115.735, 90, 90, 120
R / Rfree (%) 18.4 / 20.3

Zinc Binding Sites:

The binding sites of Zinc atom in the Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Rac-Trans-3,4-Dihydroxysulfolane (pdb code 7a0b). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Rac-Trans-3,4-Dihydroxysulfolane, PDB code: 7a0b:

Zinc binding site 1 out of 1 in 7a0b

Go back to Zinc Binding Sites List in 7a0b
Zinc binding site 1 out of 1 in the Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Rac-Trans-3,4-Dihydroxysulfolane


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Rac-Trans-3,4-Dihydroxysulfolane within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:23.6
occ:1.00
 ND1 A:HIS349 2.2 23.3 1.0
SG A:CYS320 2.3 23.9 1.0
SG A:CYS323 2.3 25.7 1.0
SG A:CYS318 2.3 24.1 1.0
CE1 A:HIS349 3.0 25.7 1.0
CB A:CYS323 3.3 24.3 1.0
CB A:CYS318 3.3 20.8 1.0
CG A:HIS349 3.3 24.3 1.0
CB A:CYS320 3.3 23.9 1.0
CB A:HIS349 3.7 20.0 1.0
N A:CYS323 3.9 25.1 1.0
CA A:HIS349 4.1 19.2 1.0
N A:CYS320 4.1 24.2 1.0
NE2 A:HIS349 4.2 22.7 1.0
CA A:CYS323 4.2 26.1 1.0
CA A:CYS320 4.2 25.2 1.0
CD2 A:HIS349 4.3 20.2 1.0
O A:HIS349 4.5 20.5 1.0
CA A:CYS318 4.6 21.6 1.0
C A:CYS318 4.7 26.6 1.0
C A:CYS320 4.7 26.0 1.0
C A:HIS349 4.7 21.1 1.0
O A:CYS320 4.7 27.1 1.0
O A:CYS318 4.7 27.8 1.0
CB A:VAL322 4.8 24.4 1.0
C A:VAL322 4.9 27.5 1.0

Reference:

D.Nguyen, X.Xie, S.Jakobi, F.Terwesten, A.Metz, T.X.P.Nguyen, V.A.Palchykov, A.Heine, K.Reuter, G.Klebe. Targeting A Cryptic Pocket in A Protein-Protein Contact By Disulfide-Induced Rupture of A Homodimeric Interface Acs Chem.Biol. 2021.
ISSN: ESSN 1554-8937
DOI: 10.1021/ACSCHEMBIO.1C00296
Page generated: Tue Oct 29 16:14:21 2024

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