Zinc in PDB 6zpe: Nonstructural Protein 10 (NSP10) From Sars Cov-2

All present enzymatic activity of Nonstructural Protein 10 (NSP10) From Sars Cov-2:
2.7.7.48; 3.4.19.12; 3.4.22.69; 3.6.4.12; 3.6.4.13;

The structure of Nonstructural Protein 10 (NSP10) From Sars Cov-2, PDB code: 6zpe was solved by S.Z.Fisher, F.Kozielski, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.53 / 1.58
Space group	I 21 3
Cell size a, b, c (Å), α, β, γ (°)	106.624, 106.624, 106.624, 90.00, 90.00, 90.00
R / Rfree (%)	15.2 / 16

The structure of Nonstructural Protein 10 (NSP10) From Sars Cov-2 also contains other interesting chemical elements:

Chlorine

(Cl)

3 atoms

The binding sites of Zinc atom in the Nonstructural Protein 10 (NSP10) From Sars Cov-2 (pdb code 6zpe). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Nonstructural Protein 10 (NSP10) From Sars Cov-2, PDB code: 6zpe:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Nonstructural Protein 10 (NSP10) From Sars Cov-2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Nonstructural Protein 10 (NSP10) From Sars Cov-2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:30.6 occ:1.00 NE2 A:HIS83 2.1 29.1 1.0 SG A:CYS77 2.3 31.2 1.0 SG A:CYS90 2.3 31.5 1.0 SG A:CYS74 2.3 28.6 1.0 CD2 A:HIS83 3.0 32.0 1.0 CE1 A:HIS83 3.0 32.0 1.0 CB A:CYS74 3.2 25.6 1.0 CB A:CYS90 3.3 34.1 1.0 CB A:CYS77 3.5 26.8 1.0 N A:CYS77 3.6 26.9 1.0 CA A:CYS77 4.0 27.8 1.0 ND1 A:HIS83 4.2 35.1 1.0 CG A:HIS83 4.2 30.5 1.0 O A:HOH417 4.4 44.4 1.0 CA A:CYS90 4.5 34.8 1.0 CB A:TYR76 4.5 28.5 1.0 C A:TYR76 4.5 25.3 1.0 O A:HOH461 4.6 47.6 1.0 CA A:CYS74 4.7 25.2 1.0 CB A:LYS93 4.9 38.0 1.0 CA A:TYR76 4.9 26.9 1.0 N A:LYS93 5.0 32.2 1.0 N A:TYR76 5.0 27.5 1.0 C A:CYS74 5.0 26.3 1.0

Zinc binding site 2 out of 2 in the Nonstructural Protein 10 (NSP10) From Sars Cov-2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Nonstructural Protein 10 (NSP10) From Sars Cov-2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn202 b:55.9 occ:1.00 SG A:CYS117 2.2 51.4 1.0 SG A:CYS130 2.3 68.8 1.0 SG A:CYS128 2.3 56.2 1.0 SG A:CYS120 2.3 49.9 1.0 CB A:CYS130 3.1 74.2 1.0 CB A:CYS117 3.1 43.5 1.0 CB A:CYS120 3.3 53.5 1.0 CB A:CYS128 3.4 50.6 1.0 N A:CYS120 3.8 54.3 1.0 N A:CYS130 3.9 77.7 1.0 CA A:CYS130 4.1 79.5 1.0 CA A:CYS128 4.1 47.2 1.0 CA A:CYS120 4.1 52.4 1.0 O A:HOH302 4.2 75.5 1.0 N A:SER129 4.4 68.2 1.0 C A:CYS128 4.6 61.6 1.0 CB A:VAL119 4.6 61.0 1.0 CA A:CYS117 4.6 41.6 1.0 C A:VAL119 4.9 60.9 1.0 C A:CYS120 4.9 45.4 1.0

A.Rogstam, M.Nyblom, S.Christensen, C.Sele, V.O.Talibov, T.Lindvall, A.A.Rasmussen, I.Andre, Z.Fisher, W.Knecht, F.Kozielski. Crystal Structure of Non-Structural Protein 10 From Severe Acute Respiratory Syndrome Coronavirus-2. Int J Mol Sci V. 21 2020.
ISSN: ESSN 1422-0067
PubMed: 33036230
DOI: 10.3390/IJMS21197375