Zinc in PDB 6zmt: Sars-Cov-2 NSP1 Bound to A Pre-40S-Like Ribosome Complex

All present enzymatic activity of Sars-Cov-2 NSP1 Bound to A Pre-40S-Like Ribosome Complex:
2.7.7.48; 3.4.19.12; 3.4.22.69; 3.6.4.12; 3.6.4.13; 4.2.99.18;

The binding sites of Zinc atom in the Sars-Cov-2 NSP1 Bound to A Pre-40S-Like Ribosome Complex (pdb code 6zmt). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Sars-Cov-2 NSP1 Bound to A Pre-40S-Like Ribosome Complex, PDB code: 6zmt:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Sars-Cov-2 NSP1 Bound to A Pre-40S-Like Ribosome Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Sars-Cov-2 NSP1 Bound to A Pre-40S-Like Ribosome Complex within 5.0Å range: probe atom residue distance (Å) B Occ f:Zn201 b:69.3 occ:1.00 SG f:CYS24 2.4 47.1 1.0 SG f:CYS42 2.5 43.2 1.0 SG f:CYS21 2.5 49.6 1.0 CB f:CYS39 2.5 45.0 1.0 CB f:CYS42 3.1 43.2 1.0 CB f:CYS21 3.4 49.6 1.0 N f:CYS39 3.6 45.0 1.0 CA f:CYS39 3.6 45.0 1.0 SG f:CYS39 3.7 45.0 1.0 CB f:CYS24 3.7 47.1 1.0 CG2 f:VAL23 4.2 47.5 1.0 CA f:CYS42 4.4 43.2 1.0 N f:CYS42 4.4 43.2 1.0 N f:CYS24 4.4 47.1 1.0 C f:CYS39 4.6 45.0 1.0 CA f:CYS24 4.6 47.1 1.0 O2' 2:G1495 4.7 50.0 1.0 CB f:ASN26 4.7 51.2 1.0 CA f:CYS21 4.8 49.6 1.0 C f:MET38 4.8 46.7 1.0 O f:CYS39 4.9 45.0 1.0 N3 2:G1495 4.9 50.0 1.0

Zinc binding site 2 out of 2 in the Sars-Cov-2 NSP1 Bound to A Pre-40S-Like Ribosome Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Sars-Cov-2 NSP1 Bound to A Pre-40S-Like Ribosome Complex within 5.0Å range: probe atom residue distance (Å) B Occ g:Zn500 b:97.9 occ:1.00 OE1 g:GLU125 2.2 83.4 1.0 CB g:CYS126 2.5 78.6 1.0 CD g:GLU125 2.5 83.4 1.0 CB g:LYS143 2.5 83.1 1.0 CG g:GLU125 2.5 83.4 1.0 SG g:CYS126 2.5 78.6 1.0 CG g:LYS143 2.7 83.1 1.0 N g:CYS126 2.9 78.6 1.0 CA g:CYS126 3.2 78.6 1.0 C g:GLU125 3.2 83.4 1.0 OE2 g:GLU125 3.6 83.4 1.0 O g:GLU125 3.6 83.4 1.0 CB g:GLU125 3.8 83.4 1.0 CA g:LYS143 3.9 83.1 1.0 CD g:LYS143 4.0 83.1 1.0 CA g:GLU125 4.0 83.4 1.0 OG g:SER123 4.2 76.2 1.0 N g:CYS144 4.3 75.2 1.0 C g:LYS143 4.4 83.1 1.0 SG g:CYS141 4.5 77.9 1.0 N g:LYS143 4.5 83.1 1.0 C g:CYS126 4.6 78.6 1.0 N g:GLU125 4.6 83.4 1.0 SG g:CYS144 4.6 75.2 1.0 CE g:LYS143 4.8 83.1 1.0

M.Thoms, R.Buschauer, M.Ameismeier, L.Koepke, T.Denk, M.Hirschenberger, H.Kratzat, M.Hayn, T.Mackens-Kiani, J.Cheng, J.H.Straub, C.M.Sturzel, T.Frohlich, O.Berninghausen, T.Becker, F.Kirchhoff, K.M.J.Sparrer, R.Beckmann. Structural Basis For Translational Shutdown and Immune Evasion By the NSP1 Protein of Sars-Cov-2. Science V. 369 1249 2020.
ISSN: ESSN 1095-9203
PubMed: 32680882
DOI: 10.1126/SCIENCE.ABC8665