Zinc in PDB 6z6p: Hdac-Pc-Nuc

All present enzymatic activity of Hdac-Pc-Nuc:
3.5.1.98;

The binding sites of Zinc atom in the Hdac-Pc-Nuc (pdb code 6z6p). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Hdac-Pc-Nuc, PDB code: 6z6p:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Hdac-Pc-Nuc


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Hdac-Pc-Nuc within 5.0Å range: probe atom residue distance (Å) B Occ K:Zn801 b:432.5 occ:1.00 OD2 K:ASP245 2.2 340.0 1.0 NE2 K:HIS205 2.4 372.4 1.0 CG K:ASP245 2.6 340.0 1.0 OD1 K:ASP245 2.8 340.0 1.0 CD2 K:HIS205 2.8 372.4 1.0 CB K:GLU375 2.8 429.1 1.0 N K:GLY376 3.4 398.7 1.0 C K:GLU375 3.6 429.1 1.0 CE1 K:HIS205 3.6 372.4 1.0 CA K:GLY376 3.6 398.7 1.0 CB K:PRO203 3.7 464.5 1.0 CB K:ASP245 3.8 340.0 1.0 CA K:GLU375 3.8 429.1 1.0 CG K:GLU375 3.8 429.1 1.0 CG K:HIS205 4.1 372.4 1.0 CG K:PRO203 4.1 464.5 1.0 O K:GLU375 4.2 429.1 1.0 ND1 K:HIS205 4.4 372.4 1.0 CD K:GLU375 4.5 429.1 1.0 OE2 K:GLU375 4.5 429.1 1.0 N K:GLU375 4.9 429.1 1.0 OD2 K:ASP338 5.0 345.1 1.0

Zinc binding site 2 out of 2 in the Hdac-Pc-Nuc


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Hdac-Pc-Nuc within 5.0Å range: probe atom residue distance (Å) B Occ L:Zn801 b:414.2 occ:1.00 OD1 L:ASP245 2.2 364.0 1.0 OD2 L:ASP338 2.2 342.9 1.0 ND1 L:HIS247 2.3 384.1 1.0 OH L:TYR378 2.4 373.4 1.0 CE2 L:TYR378 2.6 373.4 1.0 CG L:ASP338 2.9 342.9 1.0 CZ L:TYR378 2.9 373.4 1.0 CE1 L:HIS247 2.9 384.1 1.0 CG L:ASP245 3.2 364.0 1.0 CB L:ASP338 3.3 342.9 1.0 CG L:HIS247 3.5 384.1 1.0 OD2 L:ASP245 3.5 364.0 1.0 OD1 L:ASP338 3.7 342.9 1.0 CD2 L:TYR378 3.9 373.4 1.0 CA L:GLY376 4.0 365.4 1.0 CB L:HIS247 4.0 384.1 1.0 N L:HIS247 4.1 384.1 1.0 NE2 L:HIS247 4.1 384.1 1.0 CE1 L:TYR378 4.2 373.4 1.0 N L:GLY377 4.4 359.1 1.0 CD2 L:HIS247 4.4 384.1 1.0 N L:ILE246 4.5 350.6 1.0 CB L:ASP245 4.6 364.0 1.0 C L:GLY376 4.7 365.4 1.0 CA L:HIS247 4.7 384.1 1.0 CE1 L:HIS205 4.8 534.9 1.0 CA L:ASP338 4.8 342.9 1.0 C L:ASP245 4.9 364.0 1.0 CA L:ASP245 5.0 364.0 1.0 CG L:TYR378 5.0 373.4 1.0

J.H.Lee, D.Bollschweiler, T.Schafer, R.Huber. Structural Basis For the Regulation of Nucleosome Recognition and Hdac Activity By Histone Deacetylase Assemblies. Sci Adv V. 7 2021.
ISSN: ESSN 2375-2548
PubMed: 33523989
DOI: 10.1126/SCIADV.ABD4413