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Zinc in PDB 6yhd: Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 6-Amino-4-(2-((2R,3S,4R,5R)-3,4- Dihydroxy-5-Methoxytetrahydrofuran-2-Yl)Ethyl)-2-(Methylamino)-3,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One
Enzymatic activity of Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 6-Amino-4-(2-((2R,3S,4R,5R)-3,4- Dihydroxy-5-Methoxytetrahydrofuran-2-Yl)Ethyl)-2-(Methylamino)-3,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One
All present enzymatic activity of Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 6-Amino-4-(2-((2R,3S,4R,5R)-3,4- Dihydroxy-5-Methoxytetrahydrofuran-2-Yl)Ethyl)-2-(Methylamino)-3,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One:
2.4.2.29;
2.4.2.29;
Protein crystallography data
The structure of Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 6-Amino-4-(2-((2R,3S,4R,5R)-3,4- Dihydroxy-5-Methoxytetrahydrofuran-2-Yl)Ethyl)-2-(Methylamino)-3,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One, PDB code: 6yhd
was solved by
A.Nguyen,
A.Heine,
G.Klebe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 22.52 / 1.25 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 90.579, 65.369, 70.564, 90.00, 96.13, 90.00 |
| R / Rfree (%) | 12.1 / 14.4 |
Other elements in 6yhd:
The structure of Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 6-Amino-4-(2-((2R,3S,4R,5R)-3,4- Dihydroxy-5-Methoxytetrahydrofuran-2-Yl)Ethyl)-2-(Methylamino)-3,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One also contains other interesting chemical elements:
| Fluorine | (F) | 4 atoms |
| Chlorine | (Cl) | 1 atom |
Zinc Binding Sites:
The binding sites of Zinc atom in the Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 6-Amino-4-(2-((2R,3S,4R,5R)-3,4- Dihydroxy-5-Methoxytetrahydrofuran-2-Yl)Ethyl)-2-(Methylamino)-3,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One
(pdb code 6yhd). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 6-Amino-4-(2-((2R,3S,4R,5R)-3,4- Dihydroxy-5-Methoxytetrahydrofuran-2-Yl)Ethyl)-2-(Methylamino)-3,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One, PDB code: 6yhd:
In total only one binding site of Zinc was determined in the Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 6-Amino-4-(2-((2R,3S,4R,5R)-3,4- Dihydroxy-5-Methoxytetrahydrofuran-2-Yl)Ethyl)-2-(Methylamino)-3,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One, PDB code: 6yhd:
Zinc binding site 1 out of 1 in 6yhd
Go back to
Zinc Binding Sites List in 6yhd
Zinc binding site 1 out
of 1 in the Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 6-Amino-4-(2-((2R,3S,4R,5R)-3,4- Dihydroxy-5-Methoxytetrahydrofuran-2-Yl)Ethyl)-2-(Methylamino)-3,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 6-Amino-4-(2-((2R,3S,4R,5R)-3,4- Dihydroxy-5-Methoxytetrahydrofuran-2-Yl)Ethyl)-2-(Methylamino)-3,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One within 5.0Å range:
|
Reference:
A.Nguyen,
A.Heine,
G.Klebe.
Co-Crystallization, Nanoesi-Ms and 19F uc(Nmr) Reveal Dimer Disturbing Inhibitors and Conformational Changes at Dimer Contacts To Be Published.
Page generated: Tue Oct 29 15:07:00 2024
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