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Zinc in PDB 6ygz: Trna Guanine Transglycosylase (Tgt) Labelled with 5-Fluoro-Tryptophan in Co-Crystallized Complex with 6-Amino-4-(2-Phenylethyl)-1,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One

Enzymatic activity of Trna Guanine Transglycosylase (Tgt) Labelled with 5-Fluoro-Tryptophan in Co-Crystallized Complex with 6-Amino-4-(2-Phenylethyl)-1,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One

All present enzymatic activity of Trna Guanine Transglycosylase (Tgt) Labelled with 5-Fluoro-Tryptophan in Co-Crystallized Complex with 6-Amino-4-(2-Phenylethyl)-1,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One:
2.4.2.29;

Protein crystallography data

The structure of Trna Guanine Transglycosylase (Tgt) Labelled with 5-Fluoro-Tryptophan in Co-Crystallized Complex with 6-Amino-4-(2-Phenylethyl)-1,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One, PDB code: 6ygz was solved by A.Nguyen, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 35.56 / 1.86
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 84.800, 64.904, 71.299, 90.00, 94.14, 90.00
R / Rfree (%) 21.3 / 24.8

Other elements in 6ygz:

The structure of Trna Guanine Transglycosylase (Tgt) Labelled with 5-Fluoro-Tryptophan in Co-Crystallized Complex with 6-Amino-4-(2-Phenylethyl)-1,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One also contains other interesting chemical elements:

Fluorine (F) 4 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Trna Guanine Transglycosylase (Tgt) Labelled with 5-Fluoro-Tryptophan in Co-Crystallized Complex with 6-Amino-4-(2-Phenylethyl)-1,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One (pdb code 6ygz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna Guanine Transglycosylase (Tgt) Labelled with 5-Fluoro-Tryptophan in Co-Crystallized Complex with 6-Amino-4-(2-Phenylethyl)-1,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One, PDB code: 6ygz:

Zinc binding site 1 out of 1 in 6ygz

Go back to Zinc Binding Sites List in 6ygz
Zinc binding site 1 out of 1 in the Trna Guanine Transglycosylase (Tgt) Labelled with 5-Fluoro-Tryptophan in Co-Crystallized Complex with 6-Amino-4-(2-Phenylethyl)-1,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trna Guanine Transglycosylase (Tgt) Labelled with 5-Fluoro-Tryptophan in Co-Crystallized Complex with 6-Amino-4-(2-Phenylethyl)-1,7- Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:26.0
occ:0.79
 ND1 A:HIS349 2.2 30.8 1.0
SG A:CYS320 2.2 37.0 1.0
SG A:CYS323 2.3 32.4 1.0
SG A:CYS318 2.4 33.2 1.0
CE1 A:HIS349 3.0 31.1 1.0
CB A:CYS320 3.2 38.6 1.0
CB A:CYS318 3.3 37.1 1.0
CB A:CYS323 3.3 34.0 1.0
CG A:HIS349 3.3 28.7 1.0
CB A:HIS349 3.8 28.8 1.0
N A:CYS323 3.9 33.9 1.0
N A:CYS320 4.1 42.4 1.0
CA A:CYS320 4.1 39.6 1.0
CA A:HIS349 4.2 28.0 1.0
NE2 A:HIS349 4.2 30.6 1.0
CA A:CYS323 4.2 35.7 1.0
CD2 A:HIS349 4.4 28.9 1.0
C A:CYS320 4.6 41.3 1.0
CA A:CYS318 4.6 41.6 1.0
O A:HIS349 4.6 28.9 1.0
O A:CYS320 4.6 38.6 1.0
C A:CYS318 4.7 43.1 1.0
C A:HIS349 4.9 26.7 1.0
O A:CYS318 4.9 42.9 1.0
CB A:VAL322 4.9 37.5 1.0
C A:VAL322 5.0 32.7 1.0
CB A:LEU314 5.0 26.7 1.0

Reference:

A.Nguyen, A.Heine, G.Klebe. Co-Crystallization, 19F uc(Nmr) and Nanoesi-Ms Reveal Dimer Disturbing Inhibitors and Conformational Changes at Dimer Contacts To Be Published.
Page generated: Tue Oct 29 11:32:51 2024

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