Zinc in PDB 6xuy: Human SIRT6 13-308 in Complex with Adp-Ribose

All present enzymatic activity of Human SIRT6 13-308 in Complex with Adp-Ribose:
2.3.1.286;

The structure of Human SIRT6 13-308 in Complex with Adp-Ribose, PDB code: 6xuy was solved by W.You, C.Steegborn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.60 / 2.13
Space group	P 63
Cell size a, b, c (Å), α, β, γ (°)	91.192, 91.192, 143.997, 90.00, 90.00, 120.00
R / Rfree (%)	16.1 / 17.9

The binding sites of Zinc atom in the Human SIRT6 13-308 in Complex with Adp-Ribose (pdb code 6xuy). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human SIRT6 13-308 in Complex with Adp-Ribose, PDB code: 6xuy:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Human SIRT6 13-308 in Complex with Adp-Ribose


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human SIRT6 13-308 in Complex with Adp-Ribose within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn402 b:51.8 occ:1.00 SG A:CYS141 2.2 50.0 1.0 SG A:CYS144 2.2 51.4 1.0 SG A:CYS166 2.3 44.0 1.0 SG A:CYS177 2.3 73.2 1.0 CB A:CYS166 2.8 42.0 1.0 CB A:CYS141 3.1 45.4 1.0 CB A:CYS144 3.2 55.5 1.0 CB A:CYS177 3.4 78.2 1.0 N A:CYS144 3.4 53.9 1.0 CA A:CYS144 3.8 50.9 1.0 CA A:CYS166 4.3 37.5 1.0 CB A:LYS143 4.4 57.1 1.0 N A:GLY179 4.5 44.3 1.0 CA A:CYS141 4.5 51.3 1.0 CA A:GLY179 4.6 47.4 1.0 C A:LYS143 4.6 51.8 1.0 C A:CYS144 4.6 47.7 1.0 CB A:VAL168 4.7 53.4 1.0 CA A:CYS177 4.8 65.0 1.0 CG2 A:VAL168 4.8 48.1 1.0 CB A:THR146 4.9 45.5 1.0 CA A:LYS143 4.9 55.3 1.0 C A:CYS166 4.9 48.9 1.0 N A:LYS145 4.9 46.3 1.0

Zinc binding site 2 out of 2 in the Human SIRT6 13-308 in Complex with Adp-Ribose


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human SIRT6 13-308 in Complex with Adp-Ribose within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn402 b:57.8 occ:1.00 SG B:CYS141 2.0 53.8 1.0 SG B:CYS166 2.2 48.2 1.0 CB B:CYS144 2.3 55.4 1.0 SG B:CYS177 2.4 78.6 1.0 CB B:CYS166 2.7 46.4 1.0 CB B:CYS141 2.9 55.4 1.0 N B:CYS144 3.2 63.3 1.0 CA B:CYS144 3.3 57.1 1.0 SG B:CYS144 3.6 66.6 1.0 CB B:CYS177 3.6 72.6 1.0 CA B:CYS166 4.2 47.1 1.0 CB B:LYS143 4.3 67.6 1.0 CA B:CYS141 4.3 62.9 1.0 C B:LYS143 4.4 61.0 1.0 CA B:GLY179 4.4 71.6 1.0 N B:GLY179 4.4 67.9 1.0 C B:CYS144 4.4 58.3 1.0 N B:LYS145 4.7 66.7 1.0 CA B:LYS143 4.7 62.7 1.0 CB B:VAL168 4.9 75.4 1.0 N B:LYS143 4.9 66.3 1.0 C B:CYS166 4.9 56.2 1.0 CA B:CYS177 5.0 65.5 1.0 N B:THR146 5.0 54.7 1.0 CB B:THR146 5.0 54.8 1.0 CG2 B:VAL168 5.0 78.1 1.0 C B:CYS141 5.0 59.7 1.0

W.You, C.Steegborn. Crystal Structures of SIRT6 Complexes with the Allosteric Activator Mdl-801 Reveal Binding Site and Interaction Details To Be Published.