Zinc in PDB 6x7q: Chloramphenicol Acetyltransferase Type III in Complex with Chloramphenicol and Acetyl-Oxa(Dethia)-Coa

All present enzymatic activity of Chloramphenicol Acetyltransferase Type III in Complex with Chloramphenicol and Acetyl-Oxa(Dethia)-Coa:
2.3.1.28;

The structure of Chloramphenicol Acetyltransferase Type III in Complex with Chloramphenicol and Acetyl-Oxa(Dethia)-Coa, PDB code: 6x7q was solved by A.B.Benjamin, L.M.Stunkard, J.Ling, J.N.Nice, J.R.Lohman, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	34.33 / 1.68
Space group	P 42 21 2
Cell size a, b, c (Å), α, β, γ (°)	106.918, 106.918, 126.596, 90, 90, 90
R / Rfree (%)	15.7 / 20.1

The structure of Chloramphenicol Acetyltransferase Type III in Complex with Chloramphenicol and Acetyl-Oxa(Dethia)-Coa also contains other interesting chemical elements:

Chlorine

(Cl)

6 atoms

The binding sites of Zinc atom in the Chloramphenicol Acetyltransferase Type III in Complex with Chloramphenicol and Acetyl-Oxa(Dethia)-Coa (pdb code 6x7q). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Chloramphenicol Acetyltransferase Type III in Complex with Chloramphenicol and Acetyl-Oxa(Dethia)-Coa, PDB code: 6x7q:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Chloramphenicol Acetyltransferase Type III in Complex with Chloramphenicol and Acetyl-Oxa(Dethia)-Coa


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Chloramphenicol Acetyltransferase Type III in Complex with Chloramphenicol and Acetyl-Oxa(Dethia)-Coa within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn302 b:14.8 occ:1.00 OE1 A:GLU18 2.0 16.7 1.0 ND1 A:HIS22 2.0 15.7 1.0 CD A:GLU18 2.8 16.0 1.0 OE2 A:GLU18 2.9 16.2 1.0 CG A:HIS22 3.0 15.5 1.0 CE1 A:HIS22 3.0 15.0 1.0 CB A:HIS22 3.3 14.0 1.0 NE2 A:HIS22 4.1 15.9 1.0 CD2 A:HIS22 4.1 14.7 1.0 O A:HOH506 4.2 26.9 1.0 CG A:GLU18 4.2 15.0 1.0 O A:HOH544 4.3 36.7 1.0 CA A:HIS22 4.8 14.3 1.0 O A:HOH526 4.8 25.6 1.0

Zinc binding site 2 out of 2 in the Chloramphenicol Acetyltransferase Type III in Complex with Chloramphenicol and Acetyl-Oxa(Dethia)-Coa


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Chloramphenicol Acetyltransferase Type III in Complex with Chloramphenicol and Acetyl-Oxa(Dethia)-Coa within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn304 b:17.9 occ:0.50 ND1 C:HIS22 2.0 16.8 1.0 OE1 C:GLU18 2.0 16.6 1.0 CD C:GLU18 2.7 16.1 1.0 OE2 C:GLU18 2.8 17.6 1.0 CG C:HIS22 3.0 17.1 1.0 CE1 C:HIS22 3.0 15.5 1.0 CB C:HIS22 3.3 16.2 1.0 CD2 C:HIS22 4.1 17.8 1.0 NE2 C:HIS22 4.1 18.9 1.0 CG C:GLU18 4.2 17.1 1.0 O C:HOH542 4.3 30.9 1.0 CA C:HIS22 4.8 15.9 1.0 O C:GLU18 4.9 14.8 1.0 O C:HOH526 5.0 30.7 1.0

A.B.Benjamin, L.M.Stunkard, J.Ling, J.N.Nice, J.R.Lohman. Chloramphenicol Acetyltransferase Type III in Complex with Chloramphenicol and Acetyl-Oxa(Dethia)-Coa To Be Published.