Zinc in PDB 6wrz: Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove.

The structure of Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove., PDB code: 6wrz was solved by G.Minasov, L.Shuvalova, M.Rosas-Lemus, J.S.Brunzelle, O.Kiryukhina, K.J.F.Satchell, Center For Structural Genomics Of Infectious Diseases(Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.91 / 2.25
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	169.147, 169.147, 51.834, 90.00, 90.00, 120.00
R / Rfree (%)	16.2 / 19

The structure of Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove. also contains other interesting chemical elements:

Chlorine

(Cl)

5 atoms

The binding sites of Zinc atom in the Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove. (pdb code 6wrz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove., PDB code: 6wrz:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove. within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn4401 b:57.8 occ:1.00 NE2 B:HIS4336 2.1 75.8 1.0 SG B:CYS4327 2.3 54.3 1.0 SG B:CYS4343 2.3 63.1 1.0 SG B:CYS4330 2.3 56.1 1.0 CD2 B:HIS4336 3.0 70.8 1.0 CE1 B:HIS4336 3.1 72.0 1.0 CB B:CYS4327 3.2 55.5 1.0 CB B:CYS4343 3.2 73.6 1.0 CB B:CYS4330 3.4 55.8 1.0 N B:CYS4330 3.6 58.8 1.0 CA B:CYS4330 3.9 54.5 1.0 ND1 B:HIS4336 4.1 75.7 1.0 CG B:HIS4336 4.1 77.0 1.0 CA B:CYS4343 4.3 76.7 1.0 CB B:TYR4329 4.5 63.6 1.0 C B:TYR4329 4.6 57.5 1.0 CA B:CYS4327 4.6 53.9 1.0 CB B:LYS4346 4.7 59.3 1.0 O B:CYS4327 4.9 56.4 1.0 CA B:TYR4329 4.9 58.6 1.0 N B:LYS4346 5.0 56.9 1.0 C B:CYS4327 5.0 56.0 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove. within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn4402 b:83.0 occ:1.00 SG B:CYS4370 2.3 91.6 1.0 SG B:CYS4381 2.4 85.8 1.0 SG B:CYS4383 2.4 0.3 1.0 SG B:CYS4373 2.4 90.4 1.0 CB B:CYS4370 3.2 95.5 1.0 CB B:CYS4373 3.4 87.2 1.0 CB B:CYS4383 3.4 0.5 1.0 CB B:CYS4381 3.5 87.6 1.0 N B:CYS4373 3.7 86.8 1.0 CA B:CYS4381 4.0 85.1 1.0 N B:CYS4383 4.0 0.5 1.0 CA B:CYS4373 4.1 84.5 1.0 CA B:CYS4383 4.3 0.9 1.0 N B:SER4382 4.4 94.0 1.0 C B:CYS4381 4.6 88.8 1.0 CB B:VAL4372 4.6 98.8 1.0 CA B:CYS4370 4.7 91.5 1.0 C B:VAL4372 4.8 88.7 1.0 C B:CYS4373 4.9 78.3 1.0 N B:GLY4374 5.0 76.4 1.0

G.Minasov, L.Shuvalova, M.Rosas-Lemus, J.S.Brunzelle, O.Kiryukhina, K.J.F.Satchell, Center For Structural Genomics Of Infectious Diseases(Csgid). Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7-Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove. To Be Published.