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Zinc in PDB 6wq8: Carbonic Anhydrase II Complexed with 3-((2-((Furan-2-Ylmethyl)(4- Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino)Propanoic AcidEnzymatic activity of Carbonic Anhydrase II Complexed with 3-((2-((Furan-2-Ylmethyl)(4- Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino)Propanoic Acid
All present enzymatic activity of Carbonic Anhydrase II Complexed with 3-((2-((Furan-2-Ylmethyl)(4- Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino)Propanoic Acid:
4.2.1.1; Protein crystallography data
The structure of Carbonic Anhydrase II Complexed with 3-((2-((Furan-2-Ylmethyl)(4- Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino)Propanoic Acid, PDB code: 6wq8
was solved by
J.T.Andring,
J.E.Combs,
C.Lomelino,
R.Mckenna,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Carbonic Anhydrase II Complexed with 3-((2-((Furan-2-Ylmethyl)(4- Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino)Propanoic Acid
(pdb code 6wq8). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Carbonic Anhydrase II Complexed with 3-((2-((Furan-2-Ylmethyl)(4- Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino)Propanoic Acid, PDB code: 6wq8: Zinc binding site 1 out of 1 in 6wq8Go back to Zinc Binding Sites List in 6wq8
Zinc binding site 1 out
of 1 in the Carbonic Anhydrase II Complexed with 3-((2-((Furan-2-Ylmethyl)(4- Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino)Propanoic Acid
Mono view Stereo pair view
Reference:
A.Bonardi,
A.Nocentini,
S.Bua,
J.Combs,
C.L.Lomelino,
J.Andring,
L.Lucarini,
S.Sgambellone,
E.Masini,
R.Mckenna,
P.Gratteri,
C.T.Supuran.
Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed Through A Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action. J.Med.Chem. 2020.
Page generated: Wed Dec 16 13:06:20 2020
ISSN: ISSN 0022-2623 PubMed: 32519851 DOI: 10.1021/ACS.JMEDCHEM.0C00733 |
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