Zinc in PDB 6wq3: Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 in Complex with 7-Methyl-Gpppa and S-Adenosyl-L-Homocysteine.

The structure of Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 in Complex with 7-Methyl-Gpppa and S-Adenosyl-L-Homocysteine., PDB code: 6wq3 was solved by G.Minasov, L.Shuvalova, M.Rosas-Lemus, J.S.Brunzelle, O.Kiryukhina, K.J.F.Satchell, Center For Structural Genomics Of Infectious Diseases(Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.31 / 2.10
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	169.648, 169.648, 52.055, 90.00, 90.00, 120.00
R / Rfree (%)	16.6 / 18.6

The binding sites of Zinc atom in the Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 in Complex with 7-Methyl-Gpppa and S-Adenosyl-L-Homocysteine. (pdb code 6wq3). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 in Complex with 7-Methyl-Gpppa and S-Adenosyl-L-Homocysteine., PDB code: 6wq3:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 in Complex with 7-Methyl-Gpppa and S-Adenosyl-L-Homocysteine.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 in Complex with 7-Methyl-Gpppa and S-Adenosyl-L-Homocysteine. within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn4401 b:59.6 occ:1.00 NE2 B:HIS4336 2.1 73.2 1.0 SG B:CYS4327 2.3 60.0 1.0 SG B:CYS4343 2.3 63.3 1.0 SG B:CYS4330 2.3 60.9 1.0 CD2 B:HIS4336 3.1 69.6 1.0 CE1 B:HIS4336 3.1 69.6 1.0 CB B:CYS4327 3.2 61.5 1.0 CB B:CYS4343 3.3 72.6 1.0 CB B:CYS4330 3.4 60.7 1.0 N B:CYS4330 3.7 62.6 1.0 CA B:CYS4330 4.0 59.9 1.0 ND1 B:HIS4336 4.2 68.5 1.0 CG B:HIS4336 4.2 73.1 1.0 CA B:CYS4343 4.4 74.7 1.0 C B:TYR4329 4.6 62.8 1.0 CB B:TYR4329 4.6 67.9 1.0 CA B:CYS4327 4.6 60.1 1.0 CB B:LYS4346 4.7 59.6 1.0 N B:LYS4346 5.0 55.0 1.0 O B:CYS4327 5.0 58.6 1.0 CA B:TYR4329 5.0 65.0 1.0 C B:CYS4327 5.0 59.6 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 in Complex with 7-Methyl-Gpppa and S-Adenosyl-L-Homocysteine.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 in Complex with 7-Methyl-Gpppa and S-Adenosyl-L-Homocysteine. within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn4402 b:78.2 occ:1.00 SG B:CYS4381 2.3 82.4 1.0 SG B:CYS4370 2.3 85.9 1.0 SG B:CYS4383 2.3 0.9 1.0 SG B:CYS4373 2.4 85.2 1.0 CB B:CYS4370 3.3 88.0 1.0 CB B:CYS4373 3.3 84.1 1.0 CB B:CYS4383 3.4 0.5 1.0 CB B:CYS4381 3.4 84.0 1.0 N B:CYS4373 3.7 84.8 1.0 CA B:CYS4381 4.0 81.9 1.0 N B:CYS4383 4.0 1.0 1.0 CA B:CYS4373 4.1 81.7 1.0 CA B:CYS4383 4.3 0.6 1.0 N B:SER4382 4.5 91.0 1.0 CB B:VAL4372 4.5 93.4 1.0 C B:CYS4381 4.5 86.2 1.0 CA B:CYS4370 4.7 85.9 1.0 C B:VAL4372 4.7 87.2 1.0 C B:CYS4373 4.9 75.4 1.0 CG1 B:VAL4372 4.9 93.5 1.0 CA B:VAL4372 5.0 90.9 1.0

G.Minasov, L.Shuvalova, M.Rosas-Lemus, J.S.Brunzelle, O.Kiryukhina, K.J.F.Satchell, Center For Structural Genomics Of Infectious Diseases(Csgid). Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 in Complex with 7-Methyl-Gpppa and S-Adenosyl-L-Homocysteine. To Be Published.