Zinc in PDB 6wkr: PRC2-AEBP2-JARID2 Bound to H2AK119UB1 Nucleosome

Enzymatic activity of PRC2-AEBP2-JARID2 Bound to H2AK119UB1 Nucleosome

All present enzymatic activity of PRC2-AEBP2-JARID2 Bound to H2AK119UB1 Nucleosome:
2.1.1.356;

Other elements in 6wkr:

The structure of PRC2-AEBP2-JARID2 Bound to H2AK119UB1 Nucleosome also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the PRC2-AEBP2-JARID2 Bound to H2AK119UB1 Nucleosome (pdb code 6wkr). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the PRC2-AEBP2-JARID2 Bound to H2AK119UB1 Nucleosome, PDB code: 6wkr:

Zinc binding site 1 out of 1 in 6wkr

Go back to Zinc Binding Sites List in 6wkr
Zinc binding site 1 out of 1 in the PRC2-AEBP2-JARID2 Bound to H2AK119UB1 Nucleosome


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of PRC2-AEBP2-JARID2 Bound to H2AK119UB1 Nucleosome within 5.0Å range:
probe atom residue distance (Å) B Occ
P:Zn301

b:892.7
occ:1.00
NE2 P:HIS110 3.0 681.9 1.0
CD2 P:HIS110 3.1 681.9 1.0
SG P:CYS94 3.2 824.5 1.0
CE P:MET111 3.6 705.5 1.0
CB P:CYS94 3.7 824.5 1.0
CB P:TRP91 3.9 897.0 1.0
CE1 P:HIS110 4.2 681.9 1.0
CG P:HIS110 4.3 681.9 1.0
O P:VAL96 4.4 765.7 1.0
O P:CYS89 4.6 831.5 1.0
SD P:MET111 4.6 705.5 1.0
CG P:TRP91 4.7 897.0 1.0
ND1 P:HIS110 4.9 681.9 1.0
N P:TRP91 5.0 897.0 1.0

Reference:

V.Kasinath, C.Beck, P.Sauer, S.Poepsel, J.Kosmatka, M.Faini, D.Toso, R.Aebersold, E.Nogales. JARID2 and AEBP2 Regulate PRC2 in the Presence of H2AK119UB1 and Other Histone Modifications. Science V. 371 2021.
ISSN: ESSN 1095-9203
PubMed: 33479123
DOI: 10.1126/SCIENCE.ABC3393
Page generated: Wed Mar 3 16:12:06 2021

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