Zinc in PDB 6vpc: Structure of the SPCAS9 Dna Adenine Base Editor - ABE8E

The structure of Structure of the SPCAS9 Dna Adenine Base Editor - ABE8E also contains other interesting chemical elements:

Magnesium

(Mg)

3 atoms

The binding sites of Zinc atom in the Structure of the SPCAS9 Dna Adenine Base Editor - ABE8E (pdb code 6vpc). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of the SPCAS9 Dna Adenine Base Editor - ABE8E, PDB code: 6vpc:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of the SPCAS9 Dna Adenine Base Editor - ABE8E


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of the SPCAS9 Dna Adenine Base Editor - ABE8E within 5.0Å range: probe atom residue distance (Å) B Occ E:Zn201 b:0.1 occ:1.00 SG E:CYS90 2.4 0.8 1.0 ND1 E:HIS57 2.4 0.5 1.0 SG E:CYS87 2.4 0.3 1.0 CE1 E:HIS57 2.9 0.5 1.0 CG E:HIS57 3.6 0.5 1.0 CB E:CYS87 3.7 0.3 1.0 OE1 E:GLU59 3.8 0.0 1.0 CB E:CYS90 4.0 0.8 1.0 NE2 E:HIS57 4.2 0.5 1.0 CB E:HIS57 4.2 0.5 1.0 N E:CYS87 4.3 0.3 1.0 CD E:GLU59 4.5 0.0 1.0 CD2 E:HIS57 4.5 0.5 1.0 CE E:MET89 4.6 0.9 1.0 CA E:CYS87 4.6 0.3 1.0 N E:CYS90 4.7 0.8 1.0 OE2 E:GLU59 4.7 0.0 1.0 NE2 F:HIS96 4.8 0.5 1.0 CA E:CYS90 4.9 0.8 1.0

Zinc binding site 2 out of 2 in the Structure of the SPCAS9 Dna Adenine Base Editor - ABE8E


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of the SPCAS9 Dna Adenine Base Editor - ABE8E within 5.0Å range: probe atom residue distance (Å) B Occ F:Zn201 b:0.3 occ:1.00 O6 D:8AZ26 2.1 0.9 1.0 ND1 F:HIS57 2.2 0.9 1.0 SG F:CYS87 2.4 0.7 1.0 SG F:CYS90 2.4 0.3 1.0 CE1 F:HIS57 2.8 0.9 1.0 C6 D:8AZ26 3.2 0.9 1.0 N1 D:8AZ26 3.3 0.9 1.0 CG F:HIS57 3.4 0.9 1.0 CB F:CYS87 3.5 0.7 1.0 CB F:CYS90 3.7 0.3 1.0 N F:CYS87 3.8 0.7 1.0 C5 D:8AZ26 4.0 0.9 1.0 CB F:HIS57 4.0 0.9 1.0 OE2 F:GLU59 4.0 0.9 1.0 NE2 F:HIS57 4.1 0.9 1.0 C2 D:8AZ26 4.1 0.9 1.0 CE F:MET89 4.2 0.2 1.0 CA F:CYS87 4.3 0.7 1.0 N F:CYS90 4.4 0.3 1.0 CD2 F:HIS57 4.4 0.9 1.0 OE1 F:GLU59 4.4 0.9 1.0 CD F:GLU59 4.5 0.9 1.0 C4 D:8AZ26 4.6 0.9 1.0 CA F:CYS90 4.6 0.3 1.0 N3 D:8AZ26 4.7 0.9 1.0 N7 D:8AZ26 4.7 0.9 1.0 C F:PRO86 4.9 0.0 1.0 C F:CYS87 5.0 0.7 1.0

A.Lapinaite, G.J.Knott, C.M.Palumbo, E.Lin-Shiao, M.F.Richter, K.T.Zhao, P.A.Beal, D.R.Liu, J.A.Doudna. Dna Capture By A Crispr-CAS9-Guided Adenine Base Editor. Science V. 369 566 2020.
ISSN: ESSN 1095-9203
PubMed: 32732424
DOI: 10.1126/SCIENCE.ABB1390