Zinc in PDB 6vfo: Solution Structure of the Phd of Mouse UHRF1 (NP95)

All present enzymatic activity of Solution Structure of the Phd of Mouse UHRF1 (NP95):
2.3.2.27;

The binding sites of Zinc atom in the Solution Structure of the Phd of Mouse UHRF1 (NP95) (pdb code 6vfo). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Solution Structure of the Phd of Mouse UHRF1 (NP95), PDB code: 6vfo:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Solution Structure of the Phd of Mouse UHRF1 (NP95)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Solution Structure of the Phd of Mouse UHRF1 (NP95) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:0.0 occ:1.00 SG A:CYS318 2.3 0.0 1.0 SG A:CYS321 2.3 0.0 1.0 SG A:CYS310 2.3 0.0 1.0 SG A:CYS307 2.3 0.0 1.0 HB2 A:PHE309 3.1 0.0 1.0 H A:CYS310 3.3 0.0 1.0 HB2 A:CYS321 3.3 0.0 1.0 HB3 A:CYS318 3.3 0.0 1.0 HB3 A:CYS307 3.4 0.0 1.0 CB A:CYS318 3.4 0.0 1.0 CB A:CYS321 3.5 0.0 1.0 CB A:CYS307 3.5 0.0 1.0 CB A:CYS310 3.5 0.0 1.0 HB2 A:CYS310 3.6 0.0 1.0 N A:CYS310 3.7 0.0 1.0 HB2 A:CYS318 3.7 0.0 1.0 HB2 A:CYS307 3.9 0.0 1.0 CA A:CYS310 4.0 0.0 1.0 HA A:CYS310 4.1 0.0 1.0 CB A:PHE309 4.2 0.0 1.0 HB3 A:CYS321 4.2 0.0 1.0 HD2 A:PHE309 4.3 0.0 1.0 N A:CYS321 4.3 0.0 1.0 H A:CYS321 4.4 0.0 1.0 HB2 A:LYS320 4.4 0.0 1.0 HB3 A:CYS310 4.4 0.0 1.0 C A:PHE309 4.5 0.0 1.0 HB3 A:PHE309 4.5 0.0 1.0 CA A:CYS321 4.5 0.0 1.0 C A:LYS320 4.6 0.0 1.0 CA A:CYS318 4.8 0.0 1.0 CA A:PHE309 4.8 0.0 1.0 H A:PHE309 4.8 0.0 1.0 CA A:CYS307 4.8 0.0 1.0 O A:CYS307 4.9 0.0 1.0 O A:LYS320 4.9 0.0 1.0 O A:CYS318 4.9 0.0 1.0 H A:LYS320 5.0 0.0 1.0

Zinc binding site 2 out of 3 in the Solution Structure of the Phd of Mouse UHRF1 (NP95)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Solution Structure of the Phd of Mouse UHRF1 (NP95) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn402 b:0.0 occ:1.00 ND1 A:HIS346 2.1 0.0 1.0 SG A:CYS323 2.3 0.0 1.0 SG A:CYS349 2.3 0.0 1.0 SG A:CYS326 2.3 0.0 1.0 HB2 A:HIS346 2.8 0.0 1.0 CE1 A:HIS346 3.0 0.0 1.0 CG A:HIS346 3.1 0.0 1.0 HB3 A:CYS323 3.2 0.0 1.0 HE1 A:HIS346 3.3 0.0 1.0 HB3 A:CYS326 3.4 0.0 1.0 CB A:CYS323 3.4 0.0 1.0 CB A:HIS346 3.5 0.0 1.0 CB A:CYS349 3.5 0.0 1.0 CB A:CYS326 3.5 0.0 1.0 HB2 A:CYS349 3.6 0.0 1.0 H A:CYS326 3.6 0.0 1.0 HB3 A:CYS349 3.7 0.0 1.0 HB A:VAL325 3.7 0.0 1.0 HB2 A:CYS323 3.9 0.0 1.0 HE2 A:TYR348 4.1 0.0 1.0 N A:CYS326 4.1 0.0 1.0 NE2 A:HIS346 4.2 0.0 1.0 HB3 A:HIS346 4.2 0.0 1.0 CD2 A:HIS346 4.2 0.0 1.0 H A:HIS346 4.2 0.0 1.0 N A:HIS346 4.3 0.0 1.0 O A:CYS323 4.3 0.0 1.0 HB2 A:CYS326 4.4 0.0 1.0 CE2 A:TYR348 4.4 0.0 1.0 CA A:CYS326 4.4 0.0 1.0 CA A:HIS346 4.5 0.0 1.0 OH A:TYR348 4.5 0.0 1.0 HA A:PHE345 4.6 0.0 1.0 CZ A:TYR348 4.6 0.0 1.0 C A:PHE345 4.7 0.0 1.0 CA A:CYS323 4.7 0.0 1.0 CB A:VAL325 4.8 0.0 1.0 C A:CYS323 4.8 0.0 1.0 C A:VAL325 4.9 0.0 1.0 CA A:CYS349 4.9 0.0 1.0 O A:GLY328 5.0 0.0 1.0 HH A:TYR348 5.0 0.0 1.0 H A:VAL325 5.0 0.0 1.0

Zinc binding site 3 out of 3 in the Solution Structure of the Phd of Mouse UHRF1 (NP95)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Solution Structure of the Phd of Mouse UHRF1 (NP95) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn403 b:0.0 occ:1.00 OE2 A:GLU340 2.3 0.0 1.0 SG A:CYS365 2.3 0.0 1.0 SG A:CYS341 2.4 0.0 1.0 SG A:CYS338 2.4 0.0 1.0 SG A:CYS368 2.4 0.0 1.0 H A:CYS365 2.6 0.0 1.0 CD A:GLU340 3.3 0.0 1.0 HB2 A:CYS341 3.5 0.0 1.0 CB A:CYS365 3.5 0.0 1.0 N A:CYS365 3.5 0.0 1.0 HB3 A:CYS338 3.5 0.0 1.0 HB3 A:CYS365 3.5 0.0 1.0 HB2 A:CYS368 3.6 0.0 1.0 CB A:CYS338 3.6 0.0 1.0 CB A:CYS341 3.6 0.0 1.0 CB A:CYS368 3.7 0.0 1.0 HA A:TYR364 3.9 0.0 1.0 OE1 A:GLU340 3.9 0.0 1.0 HB2 A:CYS338 4.0 0.0 1.0 CA A:CYS365 4.1 0.0 1.0 H A:CYS341 4.1 0.0 1.0 H A:CYS368 4.1 0.0 1.0 HG2 A:GLU340 4.2 0.0 1.0 HB3 A:SER367 4.3 0.0 1.0 HE2 A:PHE345 4.3 0.0 1.0 HB3 A:CYS341 4.3 0.0 1.0 HZ A:PHE345 4.3 0.0 1.0 CG A:GLU340 4.4 0.0 1.0 N A:CYS368 4.4 0.0 1.0 HB2 A:CYS365 4.4 0.0 1.0 HB3 A:CYS368 4.5 0.0 1.0 CA A:CYS368 4.5 0.0 1.0 HA A:CYS368 4.5 0.0 1.0 HB3 A:TYR364 4.5 0.0 1.0 O A:CYS365 4.5 0.0 1.0 C A:TYR364 4.6 0.0 1.0 N A:CYS341 4.6 0.0 1.0 CA A:TYR364 4.6 0.0 1.0 CA A:CYS341 4.7 0.0 1.0 C A:CYS365 4.7 0.0 1.0 HG3 A:GLU340 4.8 0.0 1.0 CE2 A:PHE345 4.8 0.0 1.0 CZ A:PHE345 4.8 0.0 1.0 HD2 A:TYR364 4.9 0.0 1.0 CA A:CYS338 5.0 0.0 1.0

A.Lemak, S.Houliston, S.Duan, C.H.Arrowsmith. Alternative Splicing and Allosteric Regulation Modulate the Chromatin Binding of UHRF1 Nucleic Acids Res. 2020.
ISSN: ESSN 1362-4962