Zinc in PDB 6v86: Parainfluenza Virus 5 L-P Complex with An Alternate Conformation of the Cd-Mtase-Ctd Module

All present enzymatic activity of Parainfluenza Virus 5 L-P Complex with An Alternate Conformation of the Cd-Mtase-Ctd Module:
2.1.1.296; 2.1.1.56; 2.7.7.48; 2.7.7.88;

The binding sites of Zinc atom in the Parainfluenza Virus 5 L-P Complex with An Alternate Conformation of the Cd-Mtase-Ctd Module (pdb code 6v86). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Parainfluenza Virus 5 L-P Complex with An Alternate Conformation of the Cd-Mtase-Ctd Module, PDB code: 6v86:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Parainfluenza Virus 5 L-P Complex with An Alternate Conformation of the Cd-Mtase-Ctd Module


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Parainfluenza Virus 5 L-P Complex with An Alternate Conformation of the Cd-Mtase-Ctd Module within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2301 b:0.7 occ:1.00 SG A:CYS1374 1.9 0.3 1.0 SG A:CYS1373 2.1 0.6 1.0 N A:CYS1374 2.8 0.3 1.0 CD1 A:ILE1138 2.9 59.6 1.0 OE1 A:GLU1168 3.0 81.2 1.0 CB A:CYS1374 3.1 0.3 1.0 CA A:CYS1374 3.3 0.3 1.0 O A:CYS1374 3.4 0.3 1.0 CD1 A:ILE1169 3.4 72.1 1.0 CD A:GLU1168 3.4 81.2 1.0 CB A:CYS1373 3.5 0.6 1.0 SG A:CYS1136 3.5 90.0 1.0 C A:CYS1373 3.6 0.6 1.0 OE2 A:GLU1168 3.6 81.2 1.0 C A:CYS1374 3.8 0.3 1.0 CA A:CYS1373 3.8 0.6 1.0 N A:CYS1373 3.9 0.6 1.0 CB A:CYS1136 3.9 90.0 1.0 CG1 A:ILE1138 4.4 59.6 1.0 CG A:GLU1168 4.4 81.2 1.0 O A:CYS1373 4.6 0.6 1.0 CA A:CYS1136 4.6 90.0 1.0 C A:SER1372 4.8 0.0 1.0 CG1 A:ILE1169 4.8 72.1 1.0

Zinc binding site 2 out of 2 in the Parainfluenza Virus 5 L-P Complex with An Alternate Conformation of the Cd-Mtase-Ctd Module


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Parainfluenza Virus 5 L-P Complex with An Alternate Conformation of the Cd-Mtase-Ctd Module within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2302 b:0.7 occ:1.00 CE1 A:HIS1368 1.6 0.5 1.0 SG A:CYS1184 2.0 30.0 1.0 NE2 A:HIS1368 2.1 0.5 1.0 CE1 A:HIS1366 2.6 0.5 1.0 ND1 A:HIS1368 2.9 0.5 1.0 ND1 A:HIS1366 2.9 0.5 1.0 NE2 A:HIS1366 3.2 0.5 1.0 SG A:CYS1181 3.3 65.0 1.0 CD2 A:HIS1368 3.4 0.5 1.0 CB A:CYS1184 3.6 30.0 1.0 CG A:HIS1366 3.7 0.5 1.0 O A:GLU1182 3.7 78.3 1.0 CG A:HIS1368 3.8 0.5 1.0 CD2 A:HIS1366 3.8 0.5 1.0 N A:CYS1184 4.1 30.0 1.0 CA A:CYS1184 4.1 30.0 1.0 CB A:HIS1366 4.7 0.5 1.0 C A:GLU1182 5.0 78.3 1.0

R.Abdella, M.Aggarwal, T.Okura, R.A.Lamb, Y.He. Structure of A Paramyxovirus Polymerase Complex Reveals A Unique Methyltransferase-Ctd Conformation. Proc.Natl.Acad.Sci.Usa 2020.
ISSN: ESSN 1091-6490
DOI: 10.1073/PNAS.1919837117