Zinc in PDB 6ugy: Crystal Structure of the Fc Fragment of Anti-Tnfa Antibody Infliximab (Remicade) in A Primative Orthorhombic Crystal Form, Lot C

The structure of Crystal Structure of the Fc Fragment of Anti-Tnfa Antibody Infliximab (Remicade) in A Primative Orthorhombic Crystal Form, Lot C, PDB code: 6ugy was solved by S.J.Mayclin, T.E.Edwards, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.10
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	50.340, 148.650, 75.980, 90.00, 90.00, 90.00
R / Rfree (%)	17.9 / 22.8

The binding sites of Zinc atom in the Crystal Structure of the Fc Fragment of Anti-Tnfa Antibody Infliximab (Remicade) in A Primative Orthorhombic Crystal Form, Lot C (pdb code 6ugy). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Crystal Structure of the Fc Fragment of Anti-Tnfa Antibody Infliximab (Remicade) in A Primative Orthorhombic Crystal Form, Lot C, PDB code: 6ugy:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Crystal Structure of the Fc Fragment of Anti-Tnfa Antibody Infliximab (Remicade) in A Primative Orthorhombic Crystal Form, Lot C


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Fc Fragment of Anti-Tnfa Antibody Infliximab (Remicade) in A Primative Orthorhombic Crystal Form, Lot C within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn501 b:28.3 occ:1.00 O A:HOH648 2.0 31.3 1.0 NE2 A:HIS313 2.0 30.6 1.0 NE2 A:HIS438 2.0 24.9 1.0 O A:ACT504 2.2 37.8 1.0 OXT A:ACT504 2.2 46.8 1.0 C A:ACT504 2.4 49.1 1.0 CE1 A:HIS313 2.9 23.4 1.0 CD2 A:HIS438 3.0 24.0 1.0 CE1 A:HIS438 3.0 22.2 1.0 CD2 A:HIS313 3.1 26.6 1.0 O A:HOH717 3.1 37.7 1.0 CH3 A:ACT504 3.7 49.1 1.0 CD1 A:LEU317 3.8 28.1 1.0 ND1 A:HIS313 4.1 23.1 1.0 ND1 A:HIS438 4.1 22.5 1.0 CG A:HIS438 4.2 25.5 1.0 CG A:HIS313 4.2 30.7 1.0

Zinc binding site 2 out of 3 in the Crystal Structure of the Fc Fragment of Anti-Tnfa Antibody Infliximab (Remicade) in A Primative Orthorhombic Crystal Form, Lot C


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the Fc Fragment of Anti-Tnfa Antibody Infliximab (Remicade) in A Primative Orthorhombic Crystal Form, Lot C within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn502 b:46.9 occ:0.77 O A:HOH626 1.8 34.0 1.0 O A:HOH723 2.0 42.1 1.0 ND1 A:HIS288 2.4 54.6 1.0 CG A:HIS288 3.2 54.9 1.0 CB A:HIS288 3.3 59.0 1.0 CE1 A:HIS288 3.5 59.5 1.0 CA A:HIS288 3.9 53.7 1.0 O A:HOH627 4.2 42.1 1.0 CD2 A:HIS288 4.4 55.2 1.0 NE2 A:HIS288 4.5 59.3 1.0 O A:HIS288 4.5 51.0 1.0 OE1 A:GLU286 4.5 55.5 1.0 C A:HIS288 4.7 56.7 1.0 O A:VAL287 4.8 57.7 1.0 O A:HOH675 5.0 39.4 1.0 N A:HIS288 5.0 52.0 1.0

Zinc binding site 3 out of 3 in the Crystal Structure of the Fc Fragment of Anti-Tnfa Antibody Infliximab (Remicade) in A Primative Orthorhombic Crystal Form, Lot C


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of the Fc Fragment of Anti-Tnfa Antibody Infliximab (Remicade) in A Primative Orthorhombic Crystal Form, Lot C within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn503 b:75.0 occ:0.48 OE1 A:GLU321 2.4 80.8 1.0 O A:HOH653 2.5 74.0 1.0 OE2 A:GLU321 2.5 84.9 1.0 CD A:GLU321 2.7 75.4 1.0 CG A:GLU321 4.2 58.2 1.0 CB A:GLU321 4.8 42.9 1.0 CG2 A:THR338 4.9 40.0 1.0

T.F.Lerch, P.Sharpe, S.J.Mayclin, T.E.Edwards, S.Polleck, J.C.Rouse, Q.Zou, H.D.Conlon. Crystal Structures of Pf-06438179/GP1111, An Infliximab Biosimilar. Biodrugs 2019.
ISSN: ISSN 1179-190X
PubMed: 31650490
DOI: 10.1007/S40259-019-00390-1