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Zinc in PDB 6uei: Crystal Structure of Human Zinc Finger Antiviral Protein

Protein crystallography data

The structure of Crystal Structure of Human Zinc Finger Antiviral Protein, PDB code: 6uei was solved by J.L.Meagher, J.L.Smith, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.97 / 2.51
Space group P 65
Cell size a, b, c (Å), α, β, γ (°) 124.350, 124.350, 43.040, 90.00, 90.00, 120.00
R / Rfree (%) 20.6 / 24.4

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Human Zinc Finger Antiviral Protein (pdb code 6uei). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of Human Zinc Finger Antiviral Protein, PDB code: 6uei:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 6uei

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Zinc binding site 1 out of 4 in the Crystal Structure of Human Zinc Finger Antiviral Protein


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Zinc Finger Antiviral Protein within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn501

b:74.4
occ:1.00
NE2 A:HIS86 2.2 65.1 1.0
SG A:CYS78 2.2 77.4 1.0
SG A:CYS82 2.3 75.6 1.0
SG A:CYS73 2.3 72.0 1.0
CB A:CYS82 2.9 72.6 1.0
CE1 A:HIS86 3.1 64.5 1.0
CD2 A:HIS86 3.2 65.5 1.0
CB A:CYS73 3.2 68.2 1.0
CB A:CYS78 3.2 73.6 1.0
ND1 A:HIS86 4.2 65.0 1.0
CG A:HIS86 4.3 64.0 1.0
NH1 A:ARG75 4.4 0.4 1.0
CA A:CYS82 4.4 73.8 1.0
CA A:CYS73 4.5 68.2 1.0
CA A:CYS78 4.7 73.5 1.0
CD A:ARG75 4.7 78.6 1.0
NE A:ARG80 4.7 79.2 1.0
CB A:ASN84 4.7 66.8 1.0
CZ A:ARG80 5.0 90.5 1.0

Zinc binding site 2 out of 4 in 6uei

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Zinc binding site 2 out of 4 in the Crystal Structure of Human Zinc Finger Antiviral Protein


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human Zinc Finger Antiviral Protein within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn502

b:83.6
occ:1.00
NE2 A:HIS110 2.1 81.1 1.0
SG A:CYS106 2.2 98.1 1.0
SG A:CYS88 2.4 76.2 1.0
SG A:CYS96 2.4 99.0 1.0
CE1 A:HIS110 2.9 81.0 1.0
CB A:CYS106 3.1 95.1 1.0
CD2 A:HIS110 3.2 81.7 1.0
CB A:CYS88 3.3 72.2 1.0
CB A:CYS96 3.4 96.2 1.0
ND1 A:HIS110 4.1 82.2 1.0
CG A:HIS110 4.2 80.6 1.0
O A:HOH650 4.2 93.5 1.0
CB A:ASN91 4.3 74.5 1.0
CA A:CYS106 4.5 96.0 1.0
O A:TYR108 4.6 85.8 1.0
N A:ASN91 4.7 74.0 1.0
CA A:CYS88 4.7 72.0 1.0
O A:HOH641 4.7 87.7 1.0
CA A:CYS96 4.8 97.5 1.0
CB A:TYR108 4.9 84.4 1.0

Zinc binding site 3 out of 4 in 6uei

Go back to Zinc Binding Sites List in 6uei
Zinc binding site 3 out of 4 in the Crystal Structure of Human Zinc Finger Antiviral Protein


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of Human Zinc Finger Antiviral Protein within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn503

b:81.3
occ:1.00
NE2 A:HIS191 2.1 66.3 1.0
SG A:CYS174 2.2 80.0 1.0
SG A:CYS182 2.3 93.8 1.0
SG A:CYS187 2.4 95.5 1.0
CE1 A:HIS191 3.0 66.0 1.0
CB A:CYS174 3.1 76.5 1.0
CD2 A:HIS191 3.2 66.6 1.0
CB A:CYS187 3.3 92.0 1.0
CB A:CYS182 3.4 90.8 1.0
O A:ARG189 4.2 73.1 1.0
ND1 A:HIS191 4.2 67.0 1.0
CB A:PHE177 4.3 71.3 1.0
CG A:HIS191 4.3 65.7 1.0
CA A:CYS174 4.5 77.4 1.0
CB A:ARG189 4.6 75.3 1.0
CA A:CYS182 4.7 91.7 1.0
N A:PHE177 4.7 74.4 1.0
CA A:CYS187 4.7 92.0 1.0
CA A:PHE177 5.0 72.1 1.0
C A:ARG189 5.0 73.2 1.0

Zinc binding site 4 out of 4 in 6uei

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Zinc binding site 4 out of 4 in the Crystal Structure of Human Zinc Finger Antiviral Protein


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of Human Zinc Finger Antiviral Protein within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn504

b:0.3
occ:1.00
NE2 A:HIS172 2.2 98.4 1.0
SG A:CYS168 2.3 0.7 1.0
SG A:CYS150 2.4 93.5 1.0
SG A:CYS162 2.6 0.7 1.0
CB A:CYS168 2.7 0.4 1.0
CE1 A:HIS172 3.0 98.3 1.0
CB A:CYS162 3.1 0.8 1.0
CB A:CYS150 3.1 89.5 1.0
CD2 A:HIS172 3.3 98.4 1.0
ND1 A:HIS172 4.2 98.7 1.0
CA A:CYS168 4.3 0.5 1.0
CG A:HIS172 4.3 96.5 1.0
CA A:CYS150 4.5 89.2 1.0
OG A:SER152 4.6 0.1 1.0
CA A:CYS162 4.6 0.6 1.0
C A:CYS168 4.9 0.8 1.0

Reference:

J.L.Meagher, M.Takata, D.Goncalves-Carneiro, S.C.Keane, A.Rebendenne, H.Ong, V.K.Orr, M.R.Macdonald, J.A.Stuckey, P.D.Bieniasz, J.L.Smith. Structure of the Zinc-Finger Antiviral Protein in Complex with Rna Reveals A Mechanism For Selective Targeting of Cg-Rich Viral Sequences. Proc.Natl.Acad.Sci.Usa 2019.
ISSN: ESSN 1091-6490
PubMed: 31719195
DOI: 10.1073/PNAS.1913232116
Page generated: Wed Dec 16 12:58:36 2020

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