Zinc in PDB 6sys: Crystal Structure of (3AR,4S,9BS)-4-(4-Hydroxyphenyl)-3A,4,5,9B- Tetrahydro-3H-Cyclopenta[C]Quinoline-8-Sulfonamide with Carbonic Anhydrase 2

Enzymatic activity of Crystal Structure of (3AR,4S,9BS)-4-(4-Hydroxyphenyl)-3A,4,5,9B- Tetrahydro-3H-Cyclopenta[C]Quinoline-8-Sulfonamide with Carbonic Anhydrase 2

All present enzymatic activity of Crystal Structure of (3AR,4S,9BS)-4-(4-Hydroxyphenyl)-3A,4,5,9B- Tetrahydro-3H-Cyclopenta[C]Quinoline-8-Sulfonamide with Carbonic Anhydrase 2:
4.2.1.1;

Protein crystallography data

The structure of Crystal Structure of (3AR,4S,9BS)-4-(4-Hydroxyphenyl)-3A,4,5,9B- Tetrahydro-3H-Cyclopenta[C]Quinoline-8-Sulfonamide with Carbonic Anhydrase 2, PDB code: 6sys was solved by A.Angeli, M.Ferraroni, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 69.96 / 1.30
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.485, 41.435, 72.240, 90.00, 104.44, 90.00
R / Rfree (%) 11.9 / 16.4

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of (3AR,4S,9BS)-4-(4-Hydroxyphenyl)-3A,4,5,9B- Tetrahydro-3H-Cyclopenta[C]Quinoline-8-Sulfonamide with Carbonic Anhydrase 2 (pdb code 6sys). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of (3AR,4S,9BS)-4-(4-Hydroxyphenyl)-3A,4,5,9B- Tetrahydro-3H-Cyclopenta[C]Quinoline-8-Sulfonamide with Carbonic Anhydrase 2, PDB code: 6sys:

Zinc binding site 1 out of 1 in 6sys

Go back to Zinc Binding Sites List in 6sys
Zinc binding site 1 out of 1 in the Crystal Structure of (3AR,4S,9BS)-4-(4-Hydroxyphenyl)-3A,4,5,9B- Tetrahydro-3H-Cyclopenta[C]Quinoline-8-Sulfonamide with Carbonic Anhydrase 2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of (3AR,4S,9BS)-4-(4-Hydroxyphenyl)-3A,4,5,9B- Tetrahydro-3H-Cyclopenta[C]Quinoline-8-Sulfonamide with Carbonic Anhydrase 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:9.2
occ:1.00
 N1 A:LZW304 1.9 14.8 1.0
NE2 A:HIS94 2.0 10.4 1.0
ND1 A:HIS119 2.0 8.9 1.0
NE2 A:HIS96 2.0 8.2 1.0
CE1 A:HIS119 2.9 8.4 1.0
CD2 A:HIS94 3.0 7.8 1.0
CD2 A:HIS96 3.0 9.9 1.0
CE1 A:HIS94 3.0 7.9 1.0
O2 A:LZW304 3.0 11.7 1.0
S A:LZW304 3.0 10.6 1.0
CE1 A:HIS96 3.1 10.3 1.0
CG A:HIS119 3.2 9.2 1.0
CB A:HIS119 3.6 7.8 1.0
OG1 A:THR199 3.9 8.7 1.0
OE1 A:GLU106 4.0 10.0 1.0
O1 A:LZW304 4.1 9.2 1.0
NE2 A:HIS119 4.1 9.3 1.0
CG A:HIS94 4.2 7.9 1.0
ND1 A:HIS94 4.2 8.7 1.0
CG A:HIS96 4.2 9.5 1.0
ND1 A:HIS96 4.2 10.8 1.0
C16 A:LZW304 4.2 11.4 1.0
CD2 A:HIS119 4.2 9.6 1.0
C1 A:GOL302 4.3 35.0 1.0
C15 A:LZW304 4.8 12.7 1.0
CD A:GLU106 4.9 9.0 1.0
C2 A:GOL302 4.9 29.0 1.0

Reference:

A.Angeli, M.Ferraroni. Crystal Structure of (3AR,4S,9BS)-4-(4-Hydroxyphenyl)-3A,4,5, 9B-Tetrahydro-3H-Cyclopenta[C]Quinoline-8-Sulfonamide with Carbonic Anhydrase 2 To Be Published.
Page generated: Wed Dec 16 12:50:29 2020

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