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Zinc in PDB 6syb: Crystal Structure of Carbonic Anhydrase 2 with (3AR,4S,9BS)-4-(2- Chloro-4-Hydroxyphenyl)-3A,4,5,9B-Tetrahydro-3H- Cyclopenta[C]Quinoline-8-Sulfonamide

Enzymatic activity of Crystal Structure of Carbonic Anhydrase 2 with (3AR,4S,9BS)-4-(2- Chloro-4-Hydroxyphenyl)-3A,4,5,9B-Tetrahydro-3H- Cyclopenta[C]Quinoline-8-Sulfonamide

All present enzymatic activity of Crystal Structure of Carbonic Anhydrase 2 with (3AR,4S,9BS)-4-(2- Chloro-4-Hydroxyphenyl)-3A,4,5,9B-Tetrahydro-3H- Cyclopenta[C]Quinoline-8-Sulfonamide:
4.2.1.1;

Protein crystallography data

The structure of Crystal Structure of Carbonic Anhydrase 2 with (3AR,4S,9BS)-4-(2- Chloro-4-Hydroxyphenyl)-3A,4,5,9B-Tetrahydro-3H- Cyclopenta[C]Quinoline-8-Sulfonamide, PDB code: 6syb was solved by A.Angeli, M.Ferraroni, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 69.68 / 1.60
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.290, 41.305, 71.935, 90.00, 104.40, 90.00
R / Rfree (%) 17.4 / 21.6

Other elements in 6syb:

The structure of Crystal Structure of Carbonic Anhydrase 2 with (3AR,4S,9BS)-4-(2- Chloro-4-Hydroxyphenyl)-3A,4,5,9B-Tetrahydro-3H- Cyclopenta[C]Quinoline-8-Sulfonamide also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Carbonic Anhydrase 2 with (3AR,4S,9BS)-4-(2- Chloro-4-Hydroxyphenyl)-3A,4,5,9B-Tetrahydro-3H- Cyclopenta[C]Quinoline-8-Sulfonamide (pdb code 6syb). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Carbonic Anhydrase 2 with (3AR,4S,9BS)-4-(2- Chloro-4-Hydroxyphenyl)-3A,4,5,9B-Tetrahydro-3H- Cyclopenta[C]Quinoline-8-Sulfonamide, PDB code: 6syb:

Zinc binding site 1 out of 1 in 6syb

Go back to Zinc Binding Sites List in 6syb
Zinc binding site 1 out of 1 in the Crystal Structure of Carbonic Anhydrase 2 with (3AR,4S,9BS)-4-(2- Chloro-4-Hydroxyphenyl)-3A,4,5,9B-Tetrahydro-3H- Cyclopenta[C]Quinoline-8-Sulfonamide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Carbonic Anhydrase 2 with (3AR,4S,9BS)-4-(2- Chloro-4-Hydroxyphenyl)-3A,4,5,9B-Tetrahydro-3H- Cyclopenta[C]Quinoline-8-Sulfonamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:9.4
occ:1.00
 N1 A:LYQ303 2.0 10.2 1.0
NE2 A:HIS94 2.0 10.1 1.0
ND1 A:HIS119 2.0 8.2 1.0
NE2 A:HIS96 2.1 9.3 1.0
CE1 A:HIS119 2.9 9.0 1.0
CD2 A:HIS94 3.0 8.8 1.0
CD2 A:HIS96 3.0 9.4 1.0
O2 A:LYQ303 3.0 12.2 1.0
S A:LYQ303 3.1 11.7 1.0
CE1 A:HIS94 3.1 9.5 1.0
CE1 A:HIS96 3.1 10.4 1.0
CG A:HIS119 3.2 8.4 1.0
CB A:HIS119 3.6 9.0 1.0
OG1 A:THR199 3.9 8.8 1.0
OE1 A:GLU106 4.0 9.8 1.0
O1 A:LYQ303 4.1 11.9 1.0
NE2 A:HIS119 4.1 8.8 1.0
CG A:HIS94 4.1 9.2 1.0
ND1 A:HIS94 4.2 9.4 1.0
CG A:HIS96 4.2 9.8 1.0
ND1 A:HIS96 4.2 10.1 1.0
CD2 A:HIS119 4.2 8.5 1.0
C16 A:LYQ303 4.3 14.0 1.0
C3 A:GOL302 4.4 25.7 1.0
C15 A:LYQ303 4.8 17.1 1.0
CD A:GLU106 5.0 10.2 1.0

Reference:

A.Angeli, M.Ferraroni. Crystal Structure of Carbonic Anhydrase 2 with (3AR,4S,9BS)-4-(2-Chloro-4-Hydroxyphenyl)-3A,4,5, 9B-Tetrahydro-3H-Cyclopenta[C]Quinoline-8-Sulfonamide To Be Published.
Page generated: Tue Oct 29 07:44:31 2024

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