Zinc in PDB 6sy8: Mopeia Virus Exonuclease Domain Fully Depleted of Manganese Un Ald Compound

The structure of Mopeia Virus Exonuclease Domain Fully Depleted of Manganese Un Ald Compound, PDB code: 6sy8 was solved by T.H.V.Nguyen, F.Ferron, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	68.58 / 2.08
Space group	P 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	45.853, 38.29, 137.315, 90, 92.63, 90
R / Rfree (%)	24.8 / 28.3

The binding sites of Zinc atom in the Mopeia Virus Exonuclease Domain Fully Depleted of Manganese Un Ald Compound (pdb code 6sy8). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Mopeia Virus Exonuclease Domain Fully Depleted of Manganese Un Ald Compound, PDB code: 6sy8:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Mopeia Virus Exonuclease Domain Fully Depleted of Manganese Un Ald Compound


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Mopeia Virus Exonuclease Domain Fully Depleted of Manganese Un Ald Compound within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn601 b:44.7 occ:1.00 NE2 A:HIS510 1.9 30.1 1.0 OE2 A:GLU400 1.9 61.3 1.0 SG A:CYS530 2.4 46.6 1.0 SG A:CYS507 2.4 44.6 1.0 CD A:GLU400 2.8 56.8 1.0 CE1 A:HIS510 2.8 31.1 1.0 CD2 A:HIS510 3.0 33.2 1.0 OE1 A:GLU400 3.0 35.9 1.0 CB A:CYS530 3.2 43.5 1.0 CB A:CYS507 3.4 40.3 1.0 CA A:CYS530 3.7 44.4 1.0 NE2 A:HIS413 4.0 39.6 1.0 ND1 A:HIS510 4.0 34.0 1.0 CG A:HIS510 4.1 36.2 1.0 CG A:GLU400 4.2 35.0 1.0 CE1 A:HIS413 4.2 39.4 1.0 N A:ALA531 4.3 47.0 1.0 C A:CYS530 4.4 50.0 1.0 CE1 A:TYR415 4.5 50.4 1.0 CB A:MET509 4.8 50.6 1.0 CA A:CYS507 4.8 39.8 1.0 OH A:TYR415 4.9 54.9 1.0 N A:LEU532 4.9 44.0 1.0

Zinc binding site 2 out of 2 in the Mopeia Virus Exonuclease Domain Fully Depleted of Manganese Un Ald Compound


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Mopeia Virus Exonuclease Domain Fully Depleted of Manganese Un Ald Compound within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn601 b:35.6 occ:1.00 NE2 B:HIS510 2.0 42.5 1.0 SG B:CYS507 2.0 37.2 1.0 OE2 B:GLU400 2.0 37.0 1.0 SG B:CYS530 2.3 36.4 1.0 CD2 B:HIS510 2.8 41.7 1.0 CD B:GLU400 3.0 32.8 1.0 CB B:CYS507 3.1 35.5 1.0 CE1 B:HIS510 3.2 42.0 1.0 CB B:CYS530 3.4 32.5 1.0 OE1 B:GLU400 3.4 31.7 1.0 NE2 B:HIS413 3.8 34.1 1.0 CA B:CYS530 3.8 32.3 1.0 CE1 B:HIS413 4.0 34.2 1.0 CG B:HIS510 4.0 40.7 1.0 ND1 B:HIS510 4.2 42.7 1.0 CE1 B:TYR415 4.3 29.4 1.0 CG B:GLU400 4.4 28.8 1.0 N B:ALA531 4.5 31.4 1.0 OH B:TYR415 4.5 40.6 1.0 C B:CYS530 4.5 35.4 1.0 CA B:CYS507 4.5 36.5 1.0 CB B:MET509 4.7 42.2 1.0 CZ B:TYR415 5.0 35.7 1.0

E.Yekwa, T.H.V.Nguyen, M.Mathieu, I.Imbert, B.Selisko, B.Canard, S.Baize, F.Ferron. Serendipity in Arenaviridae Np Exonuclease Inhibitor Discovery. To Be Published.