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Zinc in PDB 6sjv: Structure of HPV18 E6 Oncoprotein in Complex with Mutant E6AP Lxxll Motif

Enzymatic activity of Structure of HPV18 E6 Oncoprotein in Complex with Mutant E6AP Lxxll Motif

All present enzymatic activity of Structure of HPV18 E6 Oncoprotein in Complex with Mutant E6AP Lxxll Motif:
2.3.2.26;

Protein crystallography data

The structure of Structure of HPV18 E6 Oncoprotein in Complex with Mutant E6AP Lxxll Motif, PDB code: 6sjv was solved by I.P.Suarez, A.Cousido-Siah, A.Bonhoure, C.Kostmann, A.Mitschler, A.Podjarny, G.Trave, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.79 / 2.03
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 106.825, 106.825, 100.377, 90.00, 90.00, 120.00
R / Rfree (%) 20.3 / 24.2

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of HPV18 E6 Oncoprotein in Complex with Mutant E6AP Lxxll Motif (pdb code 6sjv). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of HPV18 E6 Oncoprotein in Complex with Mutant E6AP Lxxll Motif, PDB code: 6sjv:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 6sjv

Go back to Zinc Binding Sites List in 6sjv
Zinc binding site 1 out of 2 in the Structure of HPV18 E6 Oncoprotein in Complex with Mutant E6AP Lxxll Motif


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of HPV18 E6 Oncoprotein in Complex with Mutant E6AP Lxxll Motif within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn2401

b:45.9
occ:1.00
SG A:CYS1105 2.2 44.4 1.0
SG A:CYS1138 2.2 45.5 1.0
SG A:CYS1141 2.3 57.6 1.0
SG A:CYS1108 2.5 44.1 1.0
CB A:CYS1105 3.2 43.6 1.0
CB A:CYS1141 3.3 49.3 1.0
CB A:CYS1138 3.3 41.0 1.0
CB A:CYS1108 3.4 48.5 1.0
N A:CYS1138 3.8 43.2 1.0
N A:CYS1108 3.8 51.5 1.0
CA A:CYS1138 4.1 46.4 1.0
CA A:CYS1108 4.2 47.5 1.0
N A:CYS1141 4.3 51.1 1.0
CA A:CYS1141 4.4 52.4 1.0
CB A:ARG1107 4.6 50.0 1.0
CA A:CYS1105 4.7 45.7 1.0
C A:ARG1107 4.7 56.6 1.0
C A:CYS1138 4.8 42.5 1.0
C A:CYS1108 4.9 46.1 1.0
O A:CYS1138 4.9 44.7 1.0
N A:ARG1107 5.0 53.3 1.0

Zinc binding site 2 out of 2 in 6sjv

Go back to Zinc Binding Sites List in 6sjv
Zinc binding site 2 out of 2 in the Structure of HPV18 E6 Oncoprotein in Complex with Mutant E6AP Lxxll Motif


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of HPV18 E6 Oncoprotein in Complex with Mutant E6AP Lxxll Motif within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn2402

b:52.6
occ:1.00
SG A:CYS1065 2.3 52.3 1.0
SG A:CYS1068 2.3 52.4 1.0
SG A:CYS1032 2.4 46.4 1.0
SG A:CYS1035 2.5 57.0 1.0
CB A:CYS1068 3.1 47.3 1.0
CB A:CYS1032 3.2 42.0 1.0
CB A:CYS1035 3.2 49.7 1.0
CB A:CYS1065 3.6 40.3 1.0
N A:CYS1035 3.8 51.0 1.0
N A:CYS1065 4.0 38.0 1.0
CA A:CYS1035 4.1 51.3 1.0
N A:CYS1068 4.1 51.2 1.0
CA A:CYS1068 4.2 45.9 1.0
CA A:CYS1065 4.3 43.3 1.0
CB A:TYR1034 4.6 52.5 1.0
CA A:CYS1032 4.7 43.3 1.0
O A:CYS1065 4.8 39.1 1.0
C A:CYS1035 4.8 55.6 1.0
C A:CYS1065 4.8 39.6 1.0
C A:TYR1034 4.8 52.6 1.0

Reference:

I.P.Suarez, A.Bonhoure, A.Cousido-Siah, Y.Chebaro, C.Kostmann, P.Eberling, D.Altschuh, A.Mitschler, A.Podjarny, G.Trave. Cellular Target Recognition By HPV18 and HPV49 Oncoproteins To Be Published.
Page generated: Tue Oct 29 07:27:36 2024

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