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Zinc in PDB 6sg6: Human Carbonic Anhydrase II in Complex with Furan-Containing Benzenesulfonamide

Enzymatic activity of Human Carbonic Anhydrase II in Complex with Furan-Containing Benzenesulfonamide

All present enzymatic activity of Human Carbonic Anhydrase II in Complex with Furan-Containing Benzenesulfonamide:
4.2.1.1;

Protein crystallography data

The structure of Human Carbonic Anhydrase II in Complex with Furan-Containing Benzenesulfonamide, PDB code: 6sg6 was solved by S.Gloeckner, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.98 / 0.98
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.336, 41.664, 72.230, 90.00, 104.42, 90.00
R / Rfree (%) 12.2 / 13.5

Other elements in 6sg6:

The structure of Human Carbonic Anhydrase II in Complex with Furan-Containing Benzenesulfonamide also contains other interesting chemical elements:

Mercury (Hg) 2 atoms
Sodium (Na) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Human Carbonic Anhydrase II in Complex with Furan-Containing Benzenesulfonamide (pdb code 6sg6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human Carbonic Anhydrase II in Complex with Furan-Containing Benzenesulfonamide, PDB code: 6sg6:

Zinc binding site 1 out of 1 in 6sg6

Go back to Zinc Binding Sites List in 6sg6
Zinc binding site 1 out of 1 in the Human Carbonic Anhydrase II in Complex with Furan-Containing Benzenesulfonamide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Carbonic Anhydrase II in Complex with Furan-Containing Benzenesulfonamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:6.8
occ:1.00
 N A:LC8304 1.9 5.6 0.7
NE2 A:HIS94 2.0 7.0 1.0
ND1 A:HIS119 2.0 7.0 1.0
NE2 A:HIS96 2.0 7.2 1.0
CE1 A:HIS119 2.9 6.7 1.0
CD2 A:HIS94 3.0 7.3 1.0
CD2 A:HIS96 3.0 6.8 1.0
CE1 A:HIS94 3.0 7.3 1.0
O1 A:LC8304 3.0 7.8 0.7
HE1 A:HIS119 3.0 8.1 1.0
S A:LC8304 3.0 6.4 0.7
CE1 A:HIS96 3.0 7.8 1.0
CG A:HIS119 3.1 6.4 1.0
HD2 A:HIS94 3.2 8.8 1.0
HD2 A:HIS96 3.2 8.2 1.0
HB2 A:HIS119 3.2 7.8 1.0
HE1 A:HIS94 3.2 8.8 1.0
HE1 A:HIS96 3.3 9.4 1.0
HG1 A:THR199 3.5 8.6 1.0
CB A:HIS119 3.6 6.5 1.0
O A:HOH580 3.7 29.9 1.0
HB3 A:HIS119 3.8 7.8 1.0
OG1 A:THR199 3.9 7.2 1.0
OE1 A:GLU106 4.0 7.2 1.0
NE2 A:HIS119 4.1 6.8 1.0
O A:LC8304 4.1 6.8 0.7
ND1 A:HIS94 4.1 7.4 1.0
CG A:HIS94 4.1 7.1 1.0
ND1 A:HIS96 4.1 8.5 1.0
CG A:HIS96 4.2 7.1 1.0
CD2 A:HIS119 4.2 6.8 1.0
C A:LC8304 4.2 8.6 0.7
HH2 A:TRP209 4.2 10.0 1.0
HG23 A:THR200 4.7 12.2 0.7
HE2 A:HIS119 4.8 8.1 1.0
C1 A:LC8304 4.9 9.6 0.7
CD A:GLU106 4.9 6.8 1.0
HD1 A:HIS94 4.9 8.9 1.0
HD1 A:HIS96 4.9 10.2 1.0
HG11 A:VAL143 5.0 9.8 1.0
C10 A:LC8304 5.0 10.3 0.7

Reference:

S.Gloeckner, A.Heine, G.Klebe. Human Carbonic Anhydrase II in Complex with Furan-Containing Benzenesulfonamide To Be Published.
Page generated: Tue Oct 29 07:20:59 2024

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