Zinc in PDB 6rfl: Structure of the Complete Vaccinia Dna-Dependent Rna Polymerase Complex
Enzymatic activity of Structure of the Complete Vaccinia Dna-Dependent Rna Polymerase Complex
All present enzymatic activity of Structure of the Complete Vaccinia Dna-Dependent Rna Polymerase Complex:
2.1.1.56;
2.7.7.6;
3.6.1.15;
Other elements in 6rfl:
The structure of Structure of the Complete Vaccinia Dna-Dependent Rna Polymerase Complex also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure of the Complete Vaccinia Dna-Dependent Rna Polymerase Complex
(pdb code 6rfl). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the
Structure of the Complete Vaccinia Dna-Dependent Rna Polymerase Complex, PDB code: 6rfl:
Jump to Zinc binding site number:
1;
2;
3;
4;
Zinc binding site 1 out
of 4 in 6rfl
Go back to
Zinc Binding Sites List in 6rfl
Zinc binding site 1 out
of 4 in the Structure of the Complete Vaccinia Dna-Dependent Rna Polymerase Complex
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Structure of the Complete Vaccinia Dna-Dependent Rna Polymerase Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Zn1201
b:48.8
occ:1.00
|
SG
|
B:CYS1103
|
2.2
|
25.5
|
1.0
|
SG
|
B:CYS1090
|
2.3
|
25.4
|
1.0
|
SG
|
B:CYS1087
|
2.3
|
25.7
|
1.0
|
SG
|
B:CYS1106
|
2.3
|
25.5
|
1.0
|
CB
|
B:CYS1106
|
3.3
|
25.5
|
1.0
|
CB
|
B:CYS1087
|
3.4
|
25.7
|
1.0
|
CB
|
B:CYS1103
|
3.5
|
25.5
|
1.0
|
CB
|
B:CYS1090
|
3.6
|
25.4
|
1.0
|
N
|
B:CYS1090
|
3.7
|
25.4
|
1.0
|
N
|
B:CYS1106
|
4.0
|
25.5
|
1.0
|
CA
|
B:CYS1106
|
4.2
|
25.5
|
1.0
|
CA
|
B:CYS1090
|
4.2
|
25.4
|
1.0
|
CB
|
B:ASN1089
|
4.3
|
26.4
|
1.0
|
CG
|
B:PRO1113
|
4.3
|
25.5
|
1.0
|
CB
|
B:PRO1113
|
4.6
|
25.5
|
1.0
|
C
|
B:ASN1089
|
4.7
|
26.4
|
1.0
|
CA
|
B:CYS1087
|
4.8
|
25.7
|
1.0
|
N
|
B:ASN1089
|
4.8
|
26.4
|
1.0
|
CA
|
B:ASN1089
|
4.8
|
26.4
|
1.0
|
CB
|
B:ARG1105
|
4.8
|
24.3
|
1.0
|
ND2
|
B:ASN1089
|
4.9
|
26.4
|
1.0
|
CA
|
B:CYS1103
|
4.9
|
25.5
|
1.0
|
|
Zinc binding site 2 out
of 4 in 6rfl
Go back to
Zinc Binding Sites List in 6rfl
Zinc binding site 2 out
of 4 in the Structure of the Complete Vaccinia Dna-Dependent Rna Polymerase Complex
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Structure of the Complete Vaccinia Dna-Dependent Rna Polymerase Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
I:Zn801
b:53.4
occ:1.00
|
ND1
|
I:HIS328
|
2.0
|
37.0
|
1.0
|
SG
|
I:CYS366
|
2.3
|
34.0
|
1.0
|
SG
|
I:CYS326
|
2.3
|
40.9
|
1.0
|
SG
|
I:CYS363
|
2.3
|
33.1
|
1.0
|
CE1
|
I:HIS328
|
2.9
|
37.0
|
1.0
|
CG
|
I:HIS328
|
3.0
|
37.0
|
1.0
|
CB
|
I:CYS326
|
3.2
|
40.9
|
1.0
|
CB
|
I:CYS363
|
3.2
|
33.1
|
1.0
|
CB
|
I:HIS328
|
3.4
|
37.0
|
1.0
|
N
|
I:CYS366
|
3.5
|
34.0
|
1.0
|
CB
|
I:CYS366
|
3.6
|
34.0
|
1.0
|
NE2
|
I:HIS328
|
3.9
|
37.0
|
1.0
|
CD2
|
I:HIS328
|
4.0
|
37.0
|
1.0
|
CB
|
I:VAL365
|
4.1
|
36.1
|
1.0
|
CA
|
I:CYS366
|
4.1
|
34.0
|
1.0
|
N
|
I:HIS328
|
4.2
|
37.0
|
1.0
|
CA
|
I:HIS328
|
4.4
|
37.0
|
1.0
|
C
|
I:VAL365
|
4.6
|
36.1
|
1.0
|
N
|
I:VAL365
|
4.6
|
36.1
|
1.0
|
CA
|
I:CYS326
|
4.6
|
40.9
|
1.0
|
CA
|
I:CYS363
|
4.6
|
33.1
|
1.0
|
CA
|
I:VAL365
|
4.7
|
36.1
|
1.0
|
C
|
I:CYS366
|
4.8
|
34.0
|
1.0
|
CG1
|
I:VAL365
|
4.8
|
36.1
|
1.0
|
N
|
I:GLU327
|
4.9
|
42.1
|
1.0
|
C
|
I:CYS326
|
5.0
|
40.9
|
1.0
|
CG2
|
I:VAL365
|
5.0
|
36.1
|
1.0
|
O
|
I:CYS366
|
5.0
|
34.0
|
1.0
|
|
Zinc binding site 3 out
of 4 in 6rfl
Go back to
Zinc Binding Sites List in 6rfl
Zinc binding site 3 out
of 4 in the Structure of the Complete Vaccinia Dna-Dependent Rna Polymerase Complex
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Structure of the Complete Vaccinia Dna-Dependent Rna Polymerase Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn1302
b:46.2
occ:1.00
|
NE2
|
A:HIS62
|
2.0
|
21.9
|
1.0
|
SG
|
A:CYS59
|
2.2
|
30.1
|
1.0
|
SG
|
A:CYS49
|
2.2
|
30.8
|
1.0
|
SG
|
A:CYS52
|
2.3
|
31.6
|
1.0
|
CD2
|
A:HIS62
|
3.0
|
21.9
|
1.0
|
CB
|
A:CYS49
|
3.0
|
30.8
|
1.0
|
CE1
|
A:HIS62
|
3.0
|
21.9
|
1.0
|
CB
|
A:CYS59
|
3.4
|
30.1
|
1.0
|
CB
|
A:CYS52
|
3.4
|
31.6
|
1.0
|
N
|
A:CYS52
|
3.8
|
31.6
|
1.0
|
ND1
|
A:HIS62
|
4.1
|
21.9
|
1.0
|
CG
|
A:HIS62
|
4.1
|
21.9
|
1.0
|
CA
|
A:CYS52
|
4.2
|
31.6
|
1.0
|
CA
|
A:CYS59
|
4.4
|
30.1
|
1.0
|
CA
|
A:CYS49
|
4.5
|
30.8
|
1.0
|
O
|
A:LEU41
|
4.5
|
27.8
|
1.0
|
CB
|
A:THR51
|
4.5
|
32.4
|
1.0
|
CA
|
A:GLY42
|
4.7
|
29.1
|
1.0
|
N
|
A:GLY61
|
4.7
|
27.6
|
1.0
|
O
|
A:HOH1416
|
4.8
|
30.7
|
1.0
|
C
|
A:THR51
|
4.8
|
32.4
|
1.0
|
N
|
A:GLY53
|
4.9
|
29.8
|
1.0
|
C
|
A:CYS52
|
4.9
|
31.6
|
1.0
|
N
|
A:THR51
|
5.0
|
32.4
|
1.0
|
CG2
|
A:THR51
|
5.0
|
32.4
|
1.0
|
CA
|
A:GLY61
|
5.0
|
27.6
|
1.0
|
|
Zinc binding site 4 out
of 4 in 6rfl
Go back to
Zinc Binding Sites List in 6rfl
Zinc binding site 4 out
of 4 in the Structure of the Complete Vaccinia Dna-Dependent Rna Polymerase Complex
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of Structure of the Complete Vaccinia Dna-Dependent Rna Polymerase Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn1303
b:60.9
occ:1.00
|
SG
|
A:CYS130
|
2.3
|
51.6
|
1.0
|
SG
|
A:CYS93
|
2.3
|
41.4
|
1.0
|
SG
|
A:CYS135
|
2.3
|
52.4
|
1.0
|
SG
|
A:CYS90
|
2.3
|
40.5
|
1.0
|
CB
|
A:CYS135
|
3.2
|
52.4
|
1.0
|
CB
|
A:CYS130
|
3.4
|
51.6
|
1.0
|
CB
|
A:CYS90
|
3.5
|
40.5
|
1.0
|
CB
|
A:CYS93
|
3.6
|
41.4
|
1.0
|
N
|
A:CYS93
|
4.0
|
41.4
|
1.0
|
CB
|
A:HIS92
|
4.3
|
43.5
|
1.0
|
CA
|
A:CYS93
|
4.4
|
41.4
|
1.0
|
CB
|
A:ASN132
|
4.4
|
50.4
|
1.0
|
CA
|
A:CYS135
|
4.6
|
52.4
|
1.0
|
C
|
A:HIS92
|
4.6
|
43.5
|
1.0
|
ND2
|
A:ASN132
|
4.7
|
50.4
|
1.0
|
N
|
A:HIS92
|
4.8
|
43.5
|
1.0
|
CA
|
A:CYS130
|
4.8
|
51.6
|
1.0
|
CA
|
A:CYS90
|
4.8
|
40.5
|
1.0
|
CA
|
A:HIS92
|
4.8
|
43.5
|
1.0
|
O
|
A:CYS90
|
4.9
|
40.5
|
1.0
|
N
|
A:MET136
|
5.0
|
54.4
|
1.0
|
C
|
A:CYS90
|
5.0
|
40.5
|
1.0
|
C
|
A:CYS135
|
5.0
|
52.4
|
1.0
|
|
Reference:
C.Grimm,
H.S.Hillen,
K.Bedenk,
J.Bartuli,
S.Neyer,
Q.Zhang,
A.Huttenhofer,
M.Erlacher,
C.Dienemann,
A.Schlosser,
H.Urlaub,
B.Bottcher,
A.A.Szalay,
P.Cramer,
U.Fischer.
Structural Basis of Poxvirus Transcription: Vaccinia Rna Polymerase Complexes. Cell V. 179 1537 2019.
ISSN: ISSN 1097-4172
PubMed: 31835032
DOI: 10.1016/J.CELL.2019.11.024
Page generated: Tue Oct 29 06:30:01 2024
|