Atomistry » Zinc » PDB 6p6z-6piz » 6pgx
Atomistry »
  Zinc »
    PDB 6p6z-6piz »
      6pgx »

Zinc in PDB 6pgx: Synthesis of Novel Tellurides Bearing Benzensulfonamide Moiety As Carbonic Anhydrase Inhibitors with Antitumor Activity

Enzymatic activity of Synthesis of Novel Tellurides Bearing Benzensulfonamide Moiety As Carbonic Anhydrase Inhibitors with Antitumor Activity

All present enzymatic activity of Synthesis of Novel Tellurides Bearing Benzensulfonamide Moiety As Carbonic Anhydrase Inhibitors with Antitumor Activity:
4.2.1.1;

Protein crystallography data

The structure of Synthesis of Novel Tellurides Bearing Benzensulfonamide Moiety As Carbonic Anhydrase Inhibitors with Antitumor Activity, PDB code: 6pgx was solved by T.S.Peat, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.13 / 1.36
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.458, 41.380, 72.430, 90.00, 104.41, 90.00
R / Rfree (%) 11.8 / 15.2

Other elements in 6pgx:

The structure of Synthesis of Novel Tellurides Bearing Benzensulfonamide Moiety As Carbonic Anhydrase Inhibitors with Antitumor Activity also contains other interesting chemical elements:

Tellurium (Te) 3 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Synthesis of Novel Tellurides Bearing Benzensulfonamide Moiety As Carbonic Anhydrase Inhibitors with Antitumor Activity (pdb code 6pgx). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Synthesis of Novel Tellurides Bearing Benzensulfonamide Moiety As Carbonic Anhydrase Inhibitors with Antitumor Activity, PDB code: 6pgx:

Zinc binding site 1 out of 1 in 6pgx

Go back to Zinc Binding Sites List in 6pgx
Zinc binding site 1 out of 1 in the Synthesis of Novel Tellurides Bearing Benzensulfonamide Moiety As Carbonic Anhydrase Inhibitors with Antitumor Activity


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Synthesis of Novel Tellurides Bearing Benzensulfonamide Moiety As Carbonic Anhydrase Inhibitors with Antitumor Activity within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:6.1
occ:1.00
N28 A:OJ4304 1.9 6.6 1.0
NE2 A:HIS94 2.0 5.6 1.0
ND1 A:HIS119 2.0 6.2 1.0
NE2 A:HIS96 2.1 5.9 1.0
CE1 A:HIS119 2.9 5.7 1.0
CD2 A:HIS94 3.0 6.4 1.0
CE1 A:HIS94 3.0 5.7 1.0
O29 A:OJ4304 3.0 7.3 1.0
CD2 A:HIS96 3.0 6.0 1.0
S26 A:OJ4304 3.0 6.9 1.0
CE1 A:HIS96 3.1 6.8 1.0
CG A:HIS119 3.1 5.2 1.0
CB A:HIS119 3.6 5.6 1.0
OG1 A:THR199 3.9 6.4 1.0
OE1 A:GLU106 4.0 7.1 1.0
O27 A:OJ4304 4.1 6.9 1.0
NE2 A:HIS119 4.1 6.1 1.0
ND1 A:HIS94 4.1 6.5 1.0
CG A:HIS94 4.2 6.1 1.0
ND1 A:HIS96 4.2 7.3 1.0
CG A:HIS96 4.2 6.8 1.0
C25 A:OJ4304 4.2 7.4 1.0
CD2 A:HIS119 4.2 5.7 1.0
C3 A:GOL305 4.4 14.4 1.0
C24 A:OJ4304 4.8 8.2 1.0
CD A:GLU106 4.9 7.8 1.0
C30 A:OJ4304 5.0 9.0 1.0

Reference:

D.Tanini, L.Ricci, A.Capperucci, L.Di Cesare Mannelli, C.Ghelardini, T.S.Peat, F.Carta, A.Angeli, C.T.Supuran. Synthesis of Novel Tellurides Bearing Benzensulfonamide Moiety As Carbonic Anhydrase Inhibitors with Antitumor Activity. Eur.J.Med.Chem. V. 181 11586 2019.
ISSN: ISSN 0223-5234
PubMed: 31401537
DOI: 10.1016/J.EJMECH.2019.111586
Page generated: Wed Dec 16 12:29:56 2020

Last articles

Zn in 7L3L
Zn in 7KSO
Zn in 7KSR
Zn in 7KTP
Zn in 7LMM
Zn in 7LMK
Zn in 7LLZ
Zn in 7LLF
Zn in 7L0N
Zn in 7LBR
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy