Zinc in PDB 6pai: Structure of the Human DDB1-DDA1-DCAF15 E3 Ubiquitin Ligase Bound to RBM39 and Sulfonamide E7820

The structure of Structure of the Human DDB1-DDA1-DCAF15 E3 Ubiquitin Ligase Bound to RBM39 and Sulfonamide E7820, PDB code: 6pai was solved by O.A.Volkov, X.Du, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.45 / 2.90
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	81.507, 94.767, 145.706, 90.00, 98.06, 90.00
R / Rfree (%)	20.8 / 25.2

The binding sites of Zinc atom in the Structure of the Human DDB1-DDA1-DCAF15 E3 Ubiquitin Ligase Bound to RBM39 and Sulfonamide E7820 (pdb code 6pai). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of the Human DDB1-DDA1-DCAF15 E3 Ubiquitin Ligase Bound to RBM39 and Sulfonamide E7820, PDB code: 6pai:

Zinc binding site 1 out of 1 in the Structure of the Human DDB1-DDA1-DCAF15 E3 Ubiquitin Ligase Bound to RBM39 and Sulfonamide E7820


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of the Human DDB1-DDA1-DCAF15 E3 Ubiquitin Ligase Bound to RBM39 and Sulfonamide E7820 within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn902 b:97.7 occ:1.00 SG C:CYS193 2.1 0.1 1.0 SG C:CYS196 2.3 0.2 1.0 ND1 C:HIS214 2.5 1.0 1.0 SG C:CYS211 2.6 0.4 1.0 CB C:CYS193 2.7 0.2 1.0 CB C:CYS196 3.3 0.4 1.0 CG C:HIS214 3.4 0.2 1.0 CB C:CYS211 3.4 0.5 1.0 CB C:HIS214 3.5 0.2 1.0 CE1 C:HIS214 3.5 0.2 1.0 N C:CYS196 3.6 0.6 1.0 CA C:CYS196 3.8 0.8 1.0 CA C:CYS193 4.2 0.7 1.0 N C:CYS211 4.2 0.3 1.0 CA C:CYS211 4.3 0.1 1.0 N C:HIS214 4.4 0.1 1.0 CD2 C:HIS214 4.5 99.5 1.0 C C:ALA195 4.5 0.3 1.0 CB C:ALA195 4.5 0.3 1.0 CA C:HIS214 4.6 98.9 1.0 NE2 C:HIS214 4.6 0.1 1.0 C C:CYS193 4.7 0.9 1.0 O C:CYS193 4.8 0.6 1.0 C C:CYS211 4.8 0.6 1.0 CA C:ALA195 4.9 0.1 1.0 CB C:PRO189 4.9 0.9 1.0

X.Du, O.A.Volkov, R.M.Czerwinski, H.Tan, C.Huerta, E.R.Morton, J.P.Rizzi, P.M.Wehn, R.Xu, D.Nijhawan, E.M.Wallace. Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 By A Sulfonamide Molecular Glue E7820. Structure V. 27 1625 2019.
ISSN: ISSN 0969-2126
PubMed: 31693911
DOI: 10.1016/J.STR.2019.10.005