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Zinc in PDB 6paf: Co-Crystal Structure of Human SMYD3 with Isoxazole Amides InhibitorsEnzymatic activity of Co-Crystal Structure of Human SMYD3 with Isoxazole Amides Inhibitors
All present enzymatic activity of Co-Crystal Structure of Human SMYD3 with Isoxazole Amides Inhibitors:
2.1.1.43; Protein crystallography data
The structure of Co-Crystal Structure of Human SMYD3 with Isoxazole Amides Inhibitors, PDB code: 6paf
was solved by
P.A.Elkins,
L.Wang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6paf:
The structure of Co-Crystal Structure of Human SMYD3 with Isoxazole Amides Inhibitors also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Co-Crystal Structure of Human SMYD3 with Isoxazole Amides Inhibitors
(pdb code 6paf). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Co-Crystal Structure of Human SMYD3 with Isoxazole Amides Inhibitors, PDB code: 6paf: Jump to Zinc binding site number: 1; 2; 3; Zinc binding site 1 out of 3 in 6pafGo back to Zinc Binding Sites List in 6paf
Zinc binding site 1 out
of 3 in the Co-Crystal Structure of Human SMYD3 with Isoxazole Amides Inhibitors
Mono view Stereo pair view
Zinc binding site 2 out of 3 in 6pafGo back to Zinc Binding Sites List in 6paf
Zinc binding site 2 out
of 3 in the Co-Crystal Structure of Human SMYD3 with Isoxazole Amides Inhibitors
Mono view Stereo pair view
Zinc binding site 3 out of 3 in 6pafGo back to Zinc Binding Sites List in 6paf
Zinc binding site 3 out
of 3 in the Co-Crystal Structure of Human SMYD3 with Isoxazole Amides Inhibitors
Mono view Stereo pair view
Reference:
D.-S.Su,
J.Qu,
M.Schultz,
C.W.Blackledge,
H.Yu,
J.Zeng,
J.Burgess,
A.Reif,
M.Stern,
R.Nagarajan,
M.Baker Pappalardi,
K.Wong,
A.P.Graves,
W.Bonnette,
L.Wang,
P.A.Elkins,
B.Knapp-Reed,
J.Carson,
C.Mchugh,
H.Mohammad,
R.Kruger,
J.Luengo,
D.A.Heerding,
C.L.Creasy.
Discovery of Isoxazone Amides As Potent and Selective SMYD3 Inhibitors Acs Med.Chem.Lett. 2019.
Page generated: Wed Dec 16 12:29:22 2020
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