Zinc in PDB 6p9g: Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with 2-(4-Oxoquinazolin-3(4H)-Yl)Propanoic Acid

Enzymatic activity of Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with 2-(4-Oxoquinazolin-3(4H)-Yl)Propanoic Acid

All present enzymatic activity of Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with 2-(4-Oxoquinazolin-3(4H)-Yl)Propanoic Acid:
3.4.19.12;

Protein crystallography data

The structure of Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with 2-(4-Oxoquinazolin-3(4H)-Yl)Propanoic Acid, PDB code: 6p9g was solved by W.Tempel, M.K.Mann, R.J.Harding, C.Bountra, C.H.Arrowsmith, A.M.Edwards, M.Schapira, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 41.00 / 2.10
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 47.846, 82.405, 99.819, 90.00, 90.00, 90.00
R / Rfree (%) 22.4 / 24.8

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with 2-(4-Oxoquinazolin-3(4H)-Yl)Propanoic Acid (pdb code 6p9g). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with 2-(4-Oxoquinazolin-3(4H)-Yl)Propanoic Acid, PDB code: 6p9g:

Zinc binding site 1 out of 1 in 6p9g

Go back to Zinc Binding Sites List in 6p9g
Zinc binding site 1 out of 1 in the Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with 2-(4-Oxoquinazolin-3(4H)-Yl)Propanoic Acid


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with 2-(4-Oxoquinazolin-3(4H)-Yl)Propanoic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:39.3
occ:1.00
 ND1 A:HIS232 2.0 38.6 1.0
SG A:CYS202 2.2 45.1 1.0
SG A:CYS219 2.3 38.8 1.0
SG A:CYS199 2.3 38.4 1.0
CE1 A:HIS232 2.9 40.2 1.0
CG A:HIS232 3.0 37.0 1.0
CB A:CYS199 3.2 40.3 1.0
CB A:CYS219 3.4 38.7 1.0
CB A:HIS232 3.4 35.5 1.0
CB A:CYS202 3.5 46.4 1.0
N A:CYS202 3.9 45.2 1.0
N A:CYS219 4.0 35.1 1.0
NE2 A:HIS232 4.1 39.2 1.0
CB A:ASN230 4.1 43.4 1.0
CD2 A:HIS232 4.1 37.6 1.0
CA A:CYS202 4.2 47.1 1.0
CA A:CYS219 4.3 35.9 1.0
C A:LYS201 4.4 44.9 1.0
CB A:LYS201 4.4 43.3 1.0
CG A:MET204 4.5 58.0 1.0
ND2 A:ASN230 4.6 45.8 1.0
CB A:MET204 4.6 56.8 1.0
CA A:CYS199 4.6 40.7 1.0
CA A:HIS232 4.7 34.6 1.0
N A:HIS232 4.7 34.2 1.0
CA A:LYS201 4.8 43.5 1.0
N A:LYS201 4.8 40.9 1.0
C A:CYS202 4.9 49.9 1.0
N A:ASN230 4.9 42.4 1.0
CG A:ASN230 4.9 46.4 1.0
CA A:ASN230 4.9 42.6 1.0

Reference:

W.Tempel, M.K.Mann, R.J.Harding, C.Bountra, C.H.Arrowsmith, A.M.Edwards, M.Schapira. Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with 2-(4-Oxoquinazolin-3(4H)-Yl)Propanoic Acid To Be Published.
Page generated: Wed Dec 16 12:29:19 2020

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