Zinc in PDB 6nus: Sars-Coronavirus NSP12 Bound to NSP8 Co-Factor

The binding sites of Zinc atom in the Sars-Coronavirus NSP12 Bound to NSP8 Co-Factor (pdb code 6nus). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Sars-Coronavirus NSP12 Bound to NSP8 Co-Factor, PDB code: 6nus:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Sars-Coronavirus NSP12 Bound to NSP8 Co-Factor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Sars-Coronavirus NSP12 Bound to NSP8 Co-Factor within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:41.7 occ:1.00 SG A:CYS301 2.2 36.8 1.0 SG A:CYS310 2.2 33.8 1.0 SG A:CYS306 2.4 63.0 1.0 ND1 A:HIS295 2.8 36.8 1.0 O A:CYS306 2.8 34.1 1.0 CB A:HIS295 3.2 33.1 1.0 CG A:HIS295 3.3 34.3 1.0 CB A:CYS310 3.3 27.8 1.0 C A:CYS306 3.5 31.7 1.0 CB A:CYS301 3.6 32.1 1.0 CB A:CYS306 3.8 38.1 1.0 CE1 A:HIS295 3.8 39.4 1.0 N A:HIS295 4.1 27.2 1.0 CA A:CYS306 4.1 31.6 1.0 CA A:CYS301 4.1 32.6 1.0 O A:HIS295 4.2 31.6 1.0 CA A:HIS295 4.2 27.6 1.0 N A:ILE307 4.3 27.6 1.0 N A:CYS310 4.3 28.2 1.0 CD2 A:HIS295 4.4 35.3 1.0 CA A:CYS310 4.4 25.9 1.0 CA A:ILE307 4.5 23.1 1.0 O A:THR293 4.6 30.3 1.0 NE2 A:HIS295 4.6 37.6 1.0 N A:CYS301 4.7 34.6 1.0 C A:HIS295 4.7 27.7 1.0 ND1 A:HIS309 5.0 27.2 1.0

Zinc binding site 2 out of 2 in the Sars-Coronavirus NSP12 Bound to NSP8 Co-Factor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Sars-Coronavirus NSP12 Bound to NSP8 Co-Factor within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1002 b:40.3 occ:1.00 SG A:CYS645 2.2 36.1 1.0 SG A:CYS487 2.3 37.6 1.0 SG A:CYS646 2.5 36.6 1.0 ND1 A:HIS642 2.5 27.5 1.0 CB A:HIS642 2.9 29.3 1.0 CG A:HIS642 3.0 27.5 1.0 CB A:CYS645 3.3 29.4 1.0 CB A:CYS646 3.3 27.8 1.0 C A:CYS645 3.5 35.4 1.0 N A:CYS646 3.5 32.4 1.0 CA A:HIS642 3.6 27.2 1.0 CE1 A:HIS642 3.6 27.4 1.0 CB A:CYS487 3.7 29.0 1.0 CA A:CYS645 3.9 31.2 1.0 O A:CYS645 3.9 36.1 1.0 CA A:CYS646 4.0 25.7 1.0 CD2 A:HIS642 4.1 27.1 1.0 C A:HIS642 4.3 30.8 1.0 N A:CYS487 4.3 29.2 1.0 N A:CYS645 4.4 32.3 1.0 O A:HIS642 4.4 35.4 1.0 NE2 A:HIS642 4.4 28.4 1.0 CA A:CYS487 4.5 27.3 1.0 N A:HIS642 4.9 28.0 1.0 CE1 A:PHE571 5.0 27.9 1.0 C A:GLY486 5.0 28.1 1.0

R.N.Kirchdoerfer, A.B.Ward. Structure of the Sars-Cov NSP12 Polymerase Bound to NSP7 and NSP8 Co-Factors. Nat Commun V. 10 2342 2019.
ISSN: ESSN 2041-1723
PubMed: 31138817
DOI: 10.1038/S41467-019-10280-3