Zinc in PDB 6nft: Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with (4-Oxoquinazolin-3(4H)-Yl)Acetic Acid

All present enzymatic activity of Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with (4-Oxoquinazolin-3(4H)-Yl)Acetic Acid:
3.4.19.12;

The structure of Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with (4-Oxoquinazolin-3(4H)-Yl)Acetic Acid, PDB code: 6nft was solved by R.J.Harding, M.K.Mann, W.Tempel, C.Bountra, C.M.Arrowmsmith, A.M.Edwards, M.Schapira, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	26.94 / 1.65
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	61.870, 85.040, 59.840, 90.00, 99.00, 90.00
R / Rfree (%)	18 / 20.6

The binding sites of Zinc atom in the Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with (4-Oxoquinazolin-3(4H)-Yl)Acetic Acid (pdb code 6nft). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with (4-Oxoquinazolin-3(4H)-Yl)Acetic Acid, PDB code: 6nft:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with (4-Oxoquinazolin-3(4H)-Yl)Acetic Acid


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with (4-Oxoquinazolin-3(4H)-Yl)Acetic Acid within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:15.2 occ:1.00 ND1 A:HIS232 2.0 16.1 1.0 SG A:CYS202 2.3 15.2 1.0 SG A:CYS219 2.3 14.9 1.0 SG A:CYS199 2.3 14.0 1.0 CE1 A:HIS232 3.0 18.4 1.0 CG A:HIS232 3.1 16.1 1.0 CB A:CYS199 3.2 15.2 1.0 CB A:CYS219 3.3 13.7 1.0 CB A:CYS202 3.4 18.1 1.0 CB A:HIS232 3.5 15.0 1.0 N A:CYS202 3.8 20.1 1.0 N A:CYS219 3.9 11.5 1.0 CA A:CYS202 4.1 19.1 1.0 NE2 A:HIS232 4.1 19.9 1.0 CD2 A:HIS232 4.2 19.1 1.0 CB A:ASN230 4.2 18.1 1.0 CA A:CYS219 4.3 12.1 1.0 C A:LYS201 4.3 21.6 1.0 CB A:LYS201 4.4 21.7 1.0 ND2 A:ASN230 4.6 19.1 1.0 CA A:CYS199 4.7 15.7 1.0 CA A:LYS201 4.7 21.6 1.0 CA A:HIS232 4.7 14.6 1.0 N A:HIS232 4.8 15.0 1.0 C A:CYS202 4.8 20.1 1.0 N A:LYS201 4.8 21.6 1.0 O A:LYS201 4.9 24.2 1.0 CB A:MET204 4.9 19.4 1.0 CG A:ASN230 4.9 20.5 1.0

Zinc binding site 2 out of 2 in the Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with (4-Oxoquinazolin-3(4H)-Yl)Acetic Acid


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with (4-Oxoquinazolin-3(4H)-Yl)Acetic Acid within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn301 b:12.2 occ:1.00 ND1 B:HIS232 2.1 11.7 1.0 SG B:CYS199 2.3 10.8 1.0 SG B:CYS202 2.3 14.2 1.0 SG B:CYS219 2.3 11.4 1.0 CE1 B:HIS232 3.0 12.6 1.0 CG B:HIS232 3.1 12.1 1.0 CB B:CYS199 3.2 11.5 1.0 CB B:CYS219 3.4 11.4 1.0 CB B:CYS202 3.4 15.5 1.0 CB B:HIS232 3.5 11.0 1.0 N B:CYS202 3.8 15.3 1.0 N B:CYS219 3.9 10.1 1.0 CA B:CYS202 4.1 16.0 1.0 NE2 B:HIS232 4.2 11.9 1.0 CD2 B:HIS232 4.3 12.8 1.0 CB B:ASN230 4.3 13.1 1.0 CA B:CYS219 4.3 10.4 1.0 C B:LYS201 4.3 17.3 1.0 CB B:LYS201 4.4 18.7 1.0 ND2 B:ASN230 4.6 15.4 1.0 CA B:CYS199 4.7 12.4 1.0 N B:HIS232 4.7 11.2 1.0 CA B:LYS201 4.7 17.2 1.0 CA B:HIS232 4.7 10.6 1.0 C B:CYS202 4.8 18.3 1.0 N B:LYS201 4.8 15.8 1.0 CB B:MET204 4.9 17.2 1.0 CG B:ASN230 4.9 14.9 1.0

R.J.Harding, M.K.Mann, W.Tempel, C.Bountra, C.M.Arrowmsmith, A.M.Edwards, M.Schapira. Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with (4-Oxoquinazolin-3(4H)-Yl)Acetic Acid To Be Published.