Zinc in PDB 6n2m: uc(Nmr) Solution Structure of the Homodimeric, Autoinhibited State of the CARD9 Card and First Coiled-Coil

The binding sites of Zinc atom in the uc(Nmr) Solution Structure of the Homodimeric, Autoinhibited State of the CARD9 Card and First Coiled-Coil (pdb code 6n2m). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the uc(Nmr) Solution Structure of the Homodimeric, Autoinhibited State of the CARD9 Card and First Coiled-Coil, PDB code: 6n2m:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the uc(Nmr) Solution Structure of the Homodimeric, Autoinhibited State of the CARD9 Card and First Coiled-Coil


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of uc(Nmr) Solution Structure of the Homodimeric, Autoinhibited State of the CARD9 Card and First Coiled-Coil within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn200 b:73.1 occ:1.00 ND1 A:HIS73 1.8 5.3 1.0 OD2 A:ASP3 1.8 22.0 1.0 SG A:CYS10 1.9 31.3 1.0 OD1 A:ASP3 2.0 21.0 1.0 CG A:ASP3 2.2 72.4 1.0 CE1 A:HIS73 2.8 31.4 1.0 HB2 A:HIS73 2.8 62.1 1.0 CG A:HIS73 2.8 24.2 1.0 HB2 A:CYS10 3.0 45.5 1.0 O A:GLU5 3.1 10.4 1.0 HE1 A:HIS73 3.1 62.4 1.0 CB A:CYS10 3.1 54.4 1.0 HA A:HIS73 3.2 2.4 1.0 CB A:HIS73 3.2 32.0 1.0 HD1 A:TYR76 3.4 74.4 1.0 HA A:CYS10 3.6 61.1 1.0 CB A:ASP3 3.7 52.2 1.0 CA A:HIS73 3.8 44.5 1.0 CD1 A:TYR76 3.9 32.3 1.0 CA A:CYS10 3.9 71.0 1.0 NE2 A:HIS73 4.0 23.1 1.0 HB3 A:CYS10 4.0 2.2 1.0 CD2 A:HIS73 4.0 63.3 1.0 HB2 A:ASP3 4.2 22.4 1.0 C A:GLU5 4.2 54.4 1.0 H A:GLU5 4.2 20.6 1.0 HB3 A:TYR76 4.2 10.1 1.0 C A:ASP3 4.2 44.4 1.0 HB3 A:HIS73 4.2 31.2 1.0 HE1 A:TYR76 4.3 53.2 1.0 HB3 A:ASP3 4.3 61.5 1.0 N A:TYR4 4.3 1.2 1.0 N A:GLU5 4.3 22.2 1.0 CE1 A:TYR76 4.3 51.2 1.0 H A:ASP3 4.4 51.5 1.0 CA A:ASP3 4.4 62.5 1.0 H A:TYR4 4.5 24.4 1.0 HG21 A:VAL77 4.5 24.1 1.0 O A:ASP3 4.6 0.0 1.0 C A:TYR4 4.6 41.2 1.0 CG A:TYR76 4.7 63.0 1.0 N A:ASP3 4.7 71.1 1.0 HA A:ASN6 4.7 51.2 1.0 C A:CYS10 4.7 14.3 1.0 N A:HIS73 4.8 75.2 1.0 O A:HIS73 4.8 44.1 1.0 C A:HIS73 4.8 3.2 1.0 HA A:TYR4 4.8 72.5 1.0 O A:CYS10 4.8 2.4 1.0 HE2 A:HIS73 4.8 37.3 1.0 CA A:TYR4 4.9 30.2 1.0 H A:ASP7 4.9 13.2 1.0 CA A:GLU5 4.9 35.2 1.0 CB A:TYR76 4.9 44.5 1.0 HD2 A:HIS73 5.0 33.1 1.0

Zinc binding site 2 out of 2 in the uc(Nmr) Solution Structure of the Homodimeric, Autoinhibited State of the CARD9 Card and First Coiled-Coil


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of uc(Nmr) Solution Structure of the Homodimeric, Autoinhibited State of the CARD9 Card and First Coiled-Coil within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn200 b:53.4 occ:1.00 OD2 B:ASP3 1.9 24.3 1.0 ND1 B:HIS73 2.0 34.2 1.0 SG B:CYS10 2.0 20.3 1.0 OD1 B:ASP3 2.2 43.3 1.0 CG B:ASP3 2.2 72.1 1.0 CE1 B:HIS73 2.8 51.4 1.0 HE1 B:HIS73 3.0 41.0 1.0 O B:ASP3 3.1 53.1 1.0 CG B:HIS73 3.1 73.1 1.0 HB2 B:CYS10 3.2 64.0 1.0 HB2 B:HIS73 3.2 41.1 1.0 CB B:CYS10 3.3 64.0 1.0 CB B:ASP3 3.6 23.1 1.0 CB B:HIS73 3.6 13.1 1.0 HA B:HIS73 3.8 65.3 1.0 HB3 B:ASP3 3.9 14.2 1.0 HD1 B:TYR76 4.0 3.2 1.0 C B:ASP3 4.0 41.4 1.0 HB3 B:CYS10 4.0 44.5 1.0 O B:GLU5 4.0 2.2 1.0 NE2 B:HIS73 4.0 61.1 1.0 HA B:CYS10 4.1 14.4 1.0 HA B:ASP3 4.1 75.3 1.0 CA B:ASP3 4.1 12.0 1.0 CD1 B:TYR76 4.2 33.1 1.0 CD2 B:HIS73 4.2 24.3 1.0 CA B:CYS10 4.3 3.1 1.0 CA B:HIS73 4.3 64.2 1.0 HB2 B:ASP3 4.4 55.5 1.0 CE1 B:TYR76 4.5 60.3 1.0 HB3 B:TYR76 4.5 44.2 1.0 HE1 B:TYR76 4.5 4.4 1.0 HB3 B:HIS73 4.6 15.0 1.0 HG21 B:VAL77 4.6 42.3 1.0 CG B:TYR76 4.7 14.2 1.0 HE2 B:HIS73 4.9 37.3 1.0 O B:CYS10 4.9 72.1 1.0 C B:CYS10 4.9 71.4 1.0

M.J.Holliday, A.Witt, A.Rodriguez Gama, B.T.Walters, C.P.Arthur, R.Halfmann, A.Rohou, E.C.Dueber, W.J.Fairbrother. Structures of Autoinhibited and Polymerized Forms of CARD9 Reveal Mechanisms of CARD9 and CARD11 Activation. Nat Commun V. 10 3070 2019.
ISSN: ESSN 2041-1723
PubMed: 31296852
DOI: 10.1038/S41467-019-10953-Z