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Zinc in PDB 6msa: Novel, Potent, Selective and Brain Penetrant Phosphodiesterase 10A InhibitorsEnzymatic activity of Novel, Potent, Selective and Brain Penetrant Phosphodiesterase 10A Inhibitors
All present enzymatic activity of Novel, Potent, Selective and Brain Penetrant Phosphodiesterase 10A Inhibitors:
3.1.4.17; 3.1.4.35; Protein crystallography data
The structure of Novel, Potent, Selective and Brain Penetrant Phosphodiesterase 10A Inhibitors, PDB code: 6msa
was solved by
C.G.Jakob,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6msa:
The structure of Novel, Potent, Selective and Brain Penetrant Phosphodiesterase 10A Inhibitors also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Novel, Potent, Selective and Brain Penetrant Phosphodiesterase 10A Inhibitors
(pdb code 6msa). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Novel, Potent, Selective and Brain Penetrant Phosphodiesterase 10A Inhibitors, PDB code: 6msa: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 6msaGo back to Zinc Binding Sites List in 6msa
Zinc binding site 1 out
of 2 in the Novel, Potent, Selective and Brain Penetrant Phosphodiesterase 10A Inhibitors
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 6msaGo back to Zinc Binding Sites List in 6msa
Zinc binding site 2 out
of 2 in the Novel, Potent, Selective and Brain Penetrant Phosphodiesterase 10A Inhibitors
Mono view Stereo pair view
Reference:
H.Geneste,
K.Drescher,
C.Jakob,
L.Laplanche,
M.Ochse,
M.Torrent.
Novel, Potent, Selective, and Brain Penetrant Phosphodiesterase 10A Inhibitors. Bioorg. Med. Chem. Lett. V. 29 406 2019.
Page generated: Wed Dec 16 12:20:29 2020
ISSN: ESSN 1464-3405 PubMed: 30587449 DOI: 10.1016/J.BMCL.2018.12.029 |
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