Zinc in PDB 6mak: HBO1 Is Required For the Maintenance of Leukaemia Stem Cells

All present enzymatic activity of HBO1 Is Required For the Maintenance of Leukaemia Stem Cells:
2.3.1.48;

The structure of HBO1 Is Required For the Maintenance of Leukaemia Stem Cells, PDB code: 6mak was solved by B.Ren, T.S.Peat, B.Monahan, M.Dawson, I.Street, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.20 / 2.13
Space group	I 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	87.628, 39.026, 107.765, 90.00, 99.59, 90.00
R / Rfree (%)	21.4 / 26.4

The binding sites of Zinc atom in the HBO1 Is Required For the Maintenance of Leukaemia Stem Cells (pdb code 6mak). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the HBO1 Is Required For the Maintenance of Leukaemia Stem Cells, PDB code: 6mak:

Zinc binding site 1 out of 1 in the HBO1 Is Required For the Maintenance of Leukaemia Stem Cells


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of HBO1 Is Required For the Maintenance of Leukaemia Stem Cells within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn701 b:51.0 occ:1.00 NE2 A:HIS384 2.1 55.7 1.0 SG A:CYS388 2.2 52.6 1.0 SG A:CYS371 2.3 50.7 1.0 SG A:CYS368 2.3 48.8 1.0 CD2 A:HIS384 3.1 56.7 1.0 CE1 A:HIS384 3.2 56.7 1.0 CB A:CYS388 3.2 60.8 1.0 CB A:CYS368 3.2 48.3 1.0 CB A:CYS371 3.2 51.2 1.0 N A:CYS371 3.8 45.2 1.0 CA A:CYS371 4.1 44.2 1.0 CG A:HIS384 4.2 61.5 1.0 ND1 A:HIS384 4.2 55.9 1.0 CA A:CYS388 4.5 60.1 1.0 CA A:CYS368 4.7 47.8 1.0 C A:CYS371 4.8 41.3 1.0 C A:PHE370 4.9 46.2 1.0 CE A:MET385 4.9 64.6 1.0 CB A:PHE370 5.0 45.6 1.0 N A:LEU372 5.0 43.9 1.0

L.Macpherson, J.Anokye, M.M.Yeung, E.Y.N.Lam, Y.C.Chan, C.F.Weng, P.Yeh, K.Knezevic, M.S.Butler, A.Hoegl, K.L.Chan, M.L.Burr, L.J.Gearing, T.Willson, J.Liu, J.Choi, Y.Yang, R.A.Bilardi, H.Falk, N.Nguyen, P.A.Stupple, T.S.Peat, M.Zhang, M.De Silva, C.Carrasco-Pozo, V.M.Avery, P.S.Khoo, O.Dolezal, M.L.Dennis, S.Nuttall, R.Surjadi, J.Newman, B.Ren, D.J.Leaver, Y.Sun, J.B.Baell, O.Dovey, G.S.Vassiliou, F.Grebien, S.J.Dawson, I.P.Street, B.J.Monahan, C.J.Burns, C.Choudhary, M.E.Blewitt, A.K.Voss, T.Thomas, M.A.Dawson. HBO1 Is Required For the Maintenance of Leukaemia Stem Cells. Nature 2019.
ISSN: ESSN 1476-4687
PubMed: 31827282
DOI: 10.1038/S41586-019-1835-6