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Atomistry » Zinc » PDB 6km3-6ksm » 6kro » |
Zinc in PDB 6kro: Tankyrase-2 in Complex with Rk-582Enzymatic activity of Tankyrase-2 in Complex with Rk-582
All present enzymatic activity of Tankyrase-2 in Complex with Rk-582:
2.4.2.30; Protein crystallography data
The structure of Tankyrase-2 in Complex with Rk-582, PDB code: 6kro
was solved by
H.Niwa,
F.Shirai,
S.Sato,
T.Tsumura,
M.Okue,
M.Shirouzu,
H.Seimiya,
T.Umehara,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6kro:
The structure of Tankyrase-2 in Complex with Rk-582 also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Tankyrase-2 in Complex with Rk-582
(pdb code 6kro). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Tankyrase-2 in Complex with Rk-582, PDB code: 6kro: Zinc binding site 1 out of 1 in 6kroGo back to Zinc Binding Sites List in 6kro
Zinc binding site 1 out
of 1 in the Tankyrase-2 in Complex with Rk-582
Mono view Stereo pair view
Reference:
F.Shirai,
A.Mizutani,
Y.Yashiroda,
T.Tsumura,
Y.Kano,
Y.Muramatsu,
T.Chikada,
H.Yuki,
H.Niwa,
S.Sato,
K.Washizuka,
Y.Koda,
Y.Mazaki,
M.K.Jang,
H.Yoshida,
A.Nagamori,
M.Okue,
T.Watanabe,
K.Kitamura,
E.Shitara,
T.Honma,
T.Umehara,
M.Shirouzu,
T.Fukami,
H.Seimiya,
M.Yoshida,
H.Koyama.
Design and Discovery of An Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor For the Treatment of Colon Cancer. J.Med.Chem. 2020.
Page generated: Tue Oct 29 02:01:55 2024
ISSN: ISSN 0022-2623 PubMed: 32202790 DOI: 10.1021/ACS.JMEDCHEM.0C00045 |
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