Zinc in PDB 6kix: Cryo-Em Structure of Human MLL1-Ncp Complex, Binding MODE1

Enzymatic activity of Cryo-Em Structure of Human MLL1-Ncp Complex, Binding MODE1

All present enzymatic activity of Cryo-Em Structure of Human MLL1-Ncp Complex, Binding MODE1:
2.1.1.43;

Zinc Binding Sites:

The binding sites of Zinc atom in the Cryo-Em Structure of Human MLL1-Ncp Complex, Binding MODE1 (pdb code 6kix). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Cryo-Em Structure of Human MLL1-Ncp Complex, Binding MODE1, PDB code: 6kix:

Zinc binding site 1 out of 1 in 6kix

Go back to Zinc Binding Sites List in 6kix
Zinc binding site 1 out of 1 in the Cryo-Em Structure of Human MLL1-Ncp Complex, Binding MODE1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of Human MLL1-Ncp Complex, Binding MODE1 within 5.0Å range:
probe atom residue distance (Å) B Occ
K:Zn4002

b:0.5
occ:1.00
N K:CYS3959 2.2 0.3 1.0
C K:CYS3957 2.4 0.5 1.0
SG K:CYS3959 2.5 0.3 1.0
CB K:CYS3957 2.6 0.5 1.0
O K:CYS3957 2.6 0.5 1.0
SG K:CYS3957 2.7 0.5 1.0
N K:ASN3958 2.8 0.0 1.0
CA K:CYS3957 3.0 0.5 1.0
CA K:CYS3959 3.1 0.3 1.0
CB K:CYS3959 3.1 0.3 1.0
C K:ASN3958 3.2 0.0 1.0
N K:GLY3960 3.3 0.4 1.0
CA K:ASN3958 3.4 0.0 1.0
C K:CYS3959 3.7 0.3 1.0
N K:CYS3957 3.9 0.5 1.0
SG K:CYS3964 3.9 0.1 1.0
O K:ASN3958 4.4 0.0 1.0
CA K:GLY3960 4.5 0.4 1.0
N6 K:SAH4001 4.7 0.7 1.0
CB K:ASN3958 4.9 0.0 1.0
O K:CYS3959 4.9 0.3 1.0

Reference:

H.Xue, T.Yao, M.Cao, G.Zhu, Y.Li, G.Yuan, Y.Chen, M.Lei, J.Huang. Structural Basis of Nucleosome Recognition and Modification By Mll Methyltransferases. Nature V. 573 445 2019.
ISSN: ESSN 1476-4687
PubMed: 31485071
DOI: 10.1038/S41586-019-1528-1
Page generated: Wed Dec 16 12:07:31 2020

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