Zinc in PDB 6iwd: The Ptp Domain of Human PTPN14 in A Complex with the CR3 Domain of HPV18 E7

Enzymatic activity of The Ptp Domain of Human PTPN14 in A Complex with the CR3 Domain of HPV18 E7

All present enzymatic activity of The Ptp Domain of Human PTPN14 in A Complex with the CR3 Domain of HPV18 E7:
3.1.3.48;

Protein crystallography data

The structure of The Ptp Domain of Human PTPN14 in A Complex with the CR3 Domain of HPV18 E7, PDB code: 6iwd was solved by H.-Y.Yun, S.J.Kim, B.Ku, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.99 / 1.80
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 54.573, 169.153, 42.530, 90.00, 90.00, 90.00
R / Rfree (%) 18.6 / 21.3

Other elements in 6iwd:

The structure of The Ptp Domain of Human PTPN14 in A Complex with the CR3 Domain of HPV18 E7 also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the The Ptp Domain of Human PTPN14 in A Complex with the CR3 Domain of HPV18 E7 (pdb code 6iwd). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the The Ptp Domain of Human PTPN14 in A Complex with the CR3 Domain of HPV18 E7, PDB code: 6iwd:

Zinc binding site 1 out of 1 in 6iwd

Go back to Zinc Binding Sites List in 6iwd
Zinc binding site 1 out of 1 in the The Ptp Domain of Human PTPN14 in A Complex with the CR3 Domain of HPV18 E7


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Ptp Domain of Human PTPN14 in A Complex with the CR3 Domain of HPV18 E7 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn201

b:41.4
occ:1.00
 SG B:CYS98 2.2 43.1 1.0
SG B:CYS68 2.3 43.1 1.0
SG B:CYS101 2.4 41.0 1.0
SG B:CYS65 2.5 31.5 1.0
CB B:CYS68 3.0 43.1 1.0
CB B:CYS101 3.3 40.5 1.0
CB B:CYS65 3.3 34.1 1.0
CB B:CYS98 3.4 35.0 1.0
N B:CYS68 3.8 41.0 1.0
CA B:CYS68 4.0 41.5 1.0
N B:CYS98 4.0 32.5 1.0
N B:CYS101 4.2 47.6 1.0
CA B:CYS98 4.2 33.5 1.0
CA B:CYS101 4.3 46.3 1.0
CB B:LYS67 4.4 37.0 1.0
C B:LYS67 4.5 40.4 1.0
C B:CYS68 4.6 47.7 1.0
CA B:CYS65 4.8 29.9 1.0
CA B:LYS67 4.8 40.2 1.0
CB B:ALA70 4.8 38.6 1.0
C B:CYS98 4.8 37.1 1.0
N B:LYS67 4.8 34.7 1.0
O B:CYS98 4.9 40.3 1.0

Reference:

H.Y.Yun, M.W.Kim, H.S.Lee, W.Kim, J.H.Shin, H.Kim, H.C.Shin, H.Park, B.H.Oh, W.K.Kim, K.H.Bae, S.C.Lee, E.W.Lee, B.Ku, S.J.Kim. Structural Basis For Recognition of the Tumor Suppressor Protein PTPN14 By the Oncoprotein E7 of Human Papillomavirus. Plos Biol. V. 17 00367 2019.
ISSN: ESSN 1545-7885
PubMed: 31323018
DOI: 10.1371/JOURNAL.PBIO.3000367
Page generated: Wed Dec 16 12:02:18 2020

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