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Zinc in PDB 6iiu: Crystal Structure of the Human Thromboxane A2 Receptor Bound to Ramatroban

Protein crystallography data

The structure of Crystal Structure of the Human Thromboxane A2 Receptor Bound to Ramatroban, PDB code: 6iiu was solved by H.Fan, Q.Zhao, B.Wu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 41.53 / 2.50
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 81.160, 155.080, 128.130, 90.00, 90.00, 90.00
R / Rfree (%) 19.8 / 21.8

Other elements in 6iiu:

The structure of Crystal Structure of the Human Thromboxane A2 Receptor Bound to Ramatroban also contains other interesting chemical elements:

Fluorine (F) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the Human Thromboxane A2 Receptor Bound to Ramatroban (pdb code 6iiu). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of the Human Thromboxane A2 Receptor Bound to Ramatroban, PDB code: 6iiu:

Zinc binding site 1 out of 1 in 6iiu

Go back to Zinc Binding Sites List in 6iiu
Zinc binding site 1 out of 1 in the Crystal Structure of the Human Thromboxane A2 Receptor Bound to Ramatroban


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Human Thromboxane A2 Receptor Bound to Ramatroban within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn9002

b:72.0
occ:1.00
SG A:CYS2006 2.2 63.6 1.0
SG A:CYS2042 2.3 76.4 1.0
SG A:CYS2039 2.5 72.6 1.0
SG A:CYS2009 2.6 77.5 1.0
CB A:CYS2006 3.2 59.8 1.0
CB A:CYS2039 3.3 68.6 1.0
CB A:CYS2042 3.4 73.8 1.0
CB A:CYS2009 3.5 73.2 1.0
N A:CYS2042 3.7 76.8 1.0
N A:CYS2009 3.9 72.2 1.0
CA A:CYS2042 4.1 75.7 1.0
CG2 A:VAL2044 4.2 71.0 1.0
CA A:CYS2009 4.2 71.6 1.0
CB A:TYR2011 4.4 62.5 1.0
CA A:CYS2006 4.6 60.0 1.0
CB A:LEU2041 4.7 76.2 1.0
CB A:VAL2008 4.7 76.6 1.0
C A:CYS2042 4.7 78.4 1.0
CA A:CYS2039 4.7 68.8 1.0
N A:GLY2043 4.7 73.7 1.0
C A:LEU2041 4.8 82.3 1.0
C A:VAL2008 4.9 76.8 1.0
N A:TYR2011 4.9 62.9 1.0
C A:CYS2009 4.9 73.7 1.0

Reference:

H.Fan, S.Chen, X.Yuan, S.Han, H.Zhang, W.Xia, Y.Xu, Q.Zhao, B.Wu. Structural Basis For Ligand Recognition of the Human Thromboxane A2RECEPTOR. Nat. Chem. Biol. V. 15 27 2019.
ISSN: ESSN 1552-4469
PubMed: 30510189
DOI: 10.1038/S41589-018-0170-9
Page generated: Wed Dec 16 12:00:39 2020

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