Zinc in PDB 6hv9: S. Cerevisiae Cmg-Pol Epsilon-Dna

All present enzymatic activity of S. Cerevisiae Cmg-Pol Epsilon-Dna:
2.7.7.7; 3.6.4.12;

The binding sites of Zinc atom in the S. Cerevisiae Cmg-Pol Epsilon-Dna (pdb code 6hv9). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the S. Cerevisiae Cmg-Pol Epsilon-Dna, PDB code: 6hv9:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the S. Cerevisiae Cmg-Pol Epsilon-Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of S. Cerevisiae Cmg-Pol Epsilon-Dna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2301 b:0.1 occ:1.00 SG A:CYS2111 2.2 0.2 1.0 SG A:CYS2133 2.2 0.5 1.0 CB A:CYS2130 2.2 0.5 1.0 SG A:CYS2130 2.2 0.5 1.0 SG A:CYS2108 2.3 0.2 1.0 CB A:CYS2111 2.6 0.2 1.0 N A:CYS2133 3.2 0.5 1.0 CB A:CYS2133 3.4 0.5 1.0 CA A:CYS2133 3.5 0.5 1.0 C A:CYS2133 3.6 0.5 1.0 O A:CYS2133 3.6 0.5 1.0 CA A:CYS2130 3.6 0.5 1.0 CB A:CYS2108 3.6 0.2 1.0 N A:CYS2111 3.8 0.2 1.0 CA A:CYS2111 3.8 0.2 1.0 C A:CYS2130 4.1 0.5 1.0 N A:HIS2134 4.3 0.9 1.0 C A:ARG2132 4.3 0.9 1.0 N A:ARG2132 4.4 0.9 1.0 N A:CYS2130 4.4 0.5 1.0 N A:VAL2131 4.4 0.3 1.0 CB A:ARG2132 4.5 0.9 1.0 CA A:ARG2132 4.7 0.9 1.0 N A:LYS2135 4.7 0.7 1.0 O A:CYS2130 4.7 0.5 1.0 C A:CYS2111 4.9 0.2 1.0 CA A:CYS2108 5.0 0.2 1.0

Zinc binding site 2 out of 2 in the S. Cerevisiae Cmg-Pol Epsilon-Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of S. Cerevisiae Cmg-Pol Epsilon-Dna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2302 b:0.5 occ:1.00 N A:CYS2167 1.4 0.9 1.0 C A:ARG2166 2.3 0.7 1.0 CB A:ARG2166 2.3 0.7 1.0 SG A:CYS2167 2.4 0.9 1.0 SG A:CYS2181 2.5 0.7 1.0 SG A:CYS2164 2.5 0.8 1.0 CA A:CYS2167 2.5 0.9 1.0 CA A:ARG2166 2.6 0.7 1.0 CB A:CYS2167 2.7 0.9 1.0 SG A:CYS2179 3.0 0.9 1.0 N A:ARG2166 3.0 0.7 1.0 CG A:ARG2166 3.1 0.7 1.0 O A:ARG2166 3.5 0.7 1.0 C A:CYS2167 3.5 0.9 1.0 CB A:CYS2164 3.6 0.8 1.0 O A:CYS2167 3.6 0.9 1.0 CD A:ARG2166 4.0 0.7 1.0 CB A:CYS2181 4.0 0.7 1.0 C A:SER2165 4.1 0.2 1.0 CB A:CYS2179 4.3 0.9 1.0 CA A:GLY2183 4.5 0.5 1.0 N A:GLY2183 4.5 0.5 1.0 N A:SER2165 4.5 0.2 1.0 O A:SER2165 4.7 0.2 1.0 C A:CYS2164 4.7 0.8 1.0 N A:HIS2168 4.8 1.0 1.0 CA A:CYS2164 4.8 0.8 1.0 NE A:ARG2166 4.9 0.7 1.0 CA A:SER2165 5.0 0.2 1.0

P.Goswami, F.Abid Ali, M.E.Douglas, J.Locke, A.Purkiss, A.Janska, P.Eickhoff, A.Early, A.Nans, A.M.C.Cheung, J.F.X.Diffley, A.Costa. Structure of Dna-Cmg-Pol Epsilon Elucidates the Roles of the Non-Catalytic Polymerase Modules in the Eukaryotic Replisome. Nat Commun V. 9 5061 2018.
ISSN: ESSN 2041-1723
PubMed: 30498216
DOI: 10.1038/S41467-018-07417-1