Zinc in PDB 6h5t: Intersectin SH3A Short Isoform

The structure of Intersectin SH3A Short Isoform, PDB code: 6h5t was solved by J.H.Driller, F.Gerth, C.Freund, M.C.Wahl, B.Loll, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.69 / 1.69
Space group	I 4 2 2
Cell size a, b, c (Å), α, β, γ (°)	86.792, 86.792, 141.768, 90.00, 90.00, 90.00
R / Rfree (%)	17.6 / 19.1

The structure of Intersectin SH3A Short Isoform also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Zinc atom in the Intersectin SH3A Short Isoform (pdb code 6h5t). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Intersectin SH3A Short Isoform, PDB code: 6h5t:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Intersectin SH3A Short Isoform


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Intersectin SH3A Short Isoform within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn903 b:20.6 occ:1.00 OD2 A:ASP757 2.0 19.3 1.0 CG A:ASP757 2.8 21.4 1.0 OD1 A:ASP757 2.9 21.8 1.0 O A:HOH1038 4.0 26.7 1.0 CB A:ASP757 4.2 18.5 1.0 OG A:SER755 4.4 20.4 1.0 CD1 A:TRP790 4.7 19.3 1.0 NE1 A:TRP790 4.9 20.8 1.0

Zinc binding site 2 out of 3 in the Intersectin SH3A Short Isoform


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Intersectin SH3A Short Isoform within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn904 b:21.0 occ:1.00 OE1 B:GLU783 2.0 22.4 1.0 NE2 A:HIS756 2.1 31.2 1.0 CD B:GLU783 2.8 27.2 1.0 CE1 A:HIS756 2.8 36.7 1.0 OE2 B:GLU783 3.0 26.0 1.0 CD2 A:HIS756 3.3 25.8 1.0 ND1 A:HIS756 4.1 38.5 1.0 CG B:GLU783 4.1 21.4 1.0 CG A:HIS756 4.3 31.6 1.0 O B:HOH1043 4.8 32.9 1.0

Zinc binding site 3 out of 3 in the Intersectin SH3A Short Isoform


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Intersectin SH3A Short Isoform within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn903 b:17.7 occ:1.00 OD2 B:ASP757 2.0 20.1 1.0 CG B:ASP757 2.8 22.6 1.0 OD1 B:ASP757 3.0 17.6 1.0 O B:HOH1041 4.0 23.9 1.0 CB B:ASP757 4.2 18.2 1.0 OG B:SER755 4.4 19.3 1.0 CD1 B:TRP790 4.5 16.0 1.0 NE1 B:TRP790 4.8 17.7 1.0

F.Gerth, M.Japel, J.Sticht, B.Kuropka, X.J.Schmitt, J.H.Driller, B.Loll, M.C.Wahl, K.Pagel, V.Haucke, C.Freund. Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain. Structure V. 27 977 2019.
ISSN: ISSN 0969-2126
PubMed: 31031201
DOI: 10.1016/J.STR.2019.03.020