Zinc in PDB 6gid: High Resolution Crystal Structure of Substrate-Free Human Neprilysin

All present enzymatic activity of High Resolution Crystal Structure of Substrate-Free Human Neprilysin:
3.4.24.11;

The structure of High Resolution Crystal Structure of Substrate-Free Human Neprilysin, PDB code: 6gid was solved by S.Moss, V.Subramanian, K.R.Acharya, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	93.03 / 1.90
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	107.424, 107.424, 112.316, 90.00, 90.00, 120.00
R / Rfree (%)	19 / 23.5

The binding sites of Zinc atom in the High Resolution Crystal Structure of Substrate-Free Human Neprilysin (pdb code 6gid). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the High Resolution Crystal Structure of Substrate-Free Human Neprilysin, PDB code: 6gid:

Zinc binding site 1 out of 1 in the High Resolution Crystal Structure of Substrate-Free Human Neprilysin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of High Resolution Crystal Structure of Substrate-Free Human Neprilysin within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn805 b:24.9 occ:1.00 OE1 A:GLU646 1.9 23.6 1.0 NE2 A:HIS583 2.0 23.1 1.0 O1 A:PO4818 2.1 32.2 0.8 NE2 A:HIS587 2.1 23.1 1.0 O3 A:PO4818 2.4 36.1 0.8 CD A:GLU646 2.7 22.3 1.0 P A:PO4818 2.7 43.2 0.8 OE2 A:GLU646 2.8 25.8 1.0 CD2 A:HIS583 3.0 20.7 1.0 CE1 A:HIS583 3.0 21.7 1.0 CD2 A:HIS587 3.1 22.6 1.0 CE1 A:HIS587 3.1 26.0 1.0 O2 A:PO4818 3.7 38.4 0.8 O4 A:PO4818 3.9 35.6 0.8 NE2 A:HIS711 4.0 28.2 1.0 ND1 A:HIS583 4.1 21.9 1.0 CG A:HIS583 4.1 20.6 1.0 CG A:GLU646 4.1 19.9 1.0 ND1 A:HIS587 4.2 23.9 1.0 CG A:HIS587 4.2 24.9 1.0 C3 A:PEG816 4.3 37.2 0.9 CD2 A:HIS711 4.3 27.4 1.0 OE1 A:GLU584 4.6 22.8 1.0 O A:HOH1153 4.6 31.1 1.0 OE2 A:GLU584 4.6 26.9 1.0 CB A:ALA649 4.6 21.0 1.0 O2 A:PEG816 4.7 43.3 0.9 CB A:GLU646 4.7 21.1 1.0 CA A:GLU646 4.7 21.5 1.0 CD A:GLU584 5.0 24.2 1.0

S.Moss, V.Subramanian, K.R.Acharya. High Resolution Crystal Structure of Substrate-Free Human Neprilysin. J. Struct. Biol. V. 204 19 2018.
ISSN: ESSN 1095-8657
PubMed: 29906506
DOI: 10.1016/J.JSB.2018.06.004