Zinc in PDB 6g8r: SP140 Phd-Bromodomain Complex with Scfv

The structure of SP140 Phd-Bromodomain Complex with Scfv, PDB code: 6g8r was solved by M.Fairhead, S.Graslund, C.Strain-Damerell, S.S.Picaud, A.C.W.Pike, D.M.Pinkas, E.Wigren, C.Preger, H.Persson Lotsholm, E.Ossipova, P.Filippakopoulos, N.A.Burgess-Brown, C.H.Arrowsmith, A.M.Edwards, C.Bountra, F.Von Delft, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	64.11 / 2.74
Space group	P 61 2 2
Cell size a, b, c (Å), α, β, γ (°)	89.200, 89.200, 343.350, 90.00, 90.00, 120.00
R / Rfree (%)	21.5 / 24.9

The binding sites of Zinc atom in the SP140 Phd-Bromodomain Complex with Scfv (pdb code 6g8r). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the SP140 Phd-Bromodomain Complex with Scfv, PDB code: 6g8r:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the SP140 Phd-Bromodomain Complex with Scfv


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of SP140 Phd-Bromodomain Complex with Scfv within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn900 b:73.9 occ:1.00 ND1 B:HIS713 2.1 79.2 1.0 SG B:CYS716 2.3 75.2 1.0 SG B:CYS693 2.3 77.2 1.0 SG B:CYS696 2.3 84.3 1.0 CE1 B:HIS713 3.1 80.0 1.0 CB B:CYS693 3.1 77.9 1.0 CG B:HIS713 3.1 78.8 1.0 CB B:CYS716 3.4 75.8 1.0 CB B:HIS713 3.5 77.8 1.0 CB B:CYS696 3.5 83.1 1.0 N B:CYS696 4.1 80.4 1.0 NE2 B:HIS713 4.2 80.3 1.0 N B:HIS713 4.2 75.6 1.0 CD2 B:HIS713 4.3 79.7 1.0 CA B:CYS696 4.3 82.0 1.0 CA B:HIS713 4.5 77.2 1.0 CA B:CYS693 4.6 77.6 1.0 CA B:CYS716 4.8 75.4 1.0 CB B:VAL695 4.8 76.4 1.0 C B:CYS696 5.0 83.0 1.0

Zinc binding site 2 out of 2 in the SP140 Phd-Bromodomain Complex with Scfv


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of SP140 Phd-Bromodomain Complex with Scfv within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn901 b:72.0 occ:1.00 SG B:CYS733 2.3 80.0 1.0 SG B:CYS705 2.3 79.2 1.0 SG B:CYS730 2.3 80.5 1.0 SG B:CYS708 2.3 82.4 1.0 CB B:CYS705 3.3 78.2 1.0 CB B:CYS733 3.3 79.4 1.0 CB B:CYS708 3.4 83.7 1.0 CB B:CYS730 3.4 79.3 1.0 NH1 B:ARG710 3.7 78.3 1.0 N B:CYS708 3.9 84.5 1.0 N B:CYS730 4.0 79.5 1.0 OG1 B:THR707 4.1 86.5 1.0 N B:CYS733 4.1 77.5 1.0 CA B:CYS730 4.2 78.5 1.0 CA B:CYS708 4.2 84.3 1.0 CA B:CYS733 4.3 78.8 1.0 O B:CYS730 4.4 76.6 1.0 C B:CYS730 4.6 77.6 1.0 CA B:CYS705 4.7 77.7 1.0 C B:CYS708 4.8 83.2 1.0 O B:HOH1002 4.9 58.3 1.0 CB B:ARG710 5.0 76.0 1.0 CZ B:ARG710 5.0 78.1 1.0

M.Fairhead, S.Graslund, C.Strain-Damerell, S.S.Picaud, A.C.W.Pike, D.M.Pinkas, E.Wigren, C.Preger, H.Persson Lotsholm, E.Ossipova, P.Filippakopoulos, N.A.Burgess-Brown, C.H.Arrowsmith, A.M.Edwards, C.Bountra, F.Von Delft. SP140 Phd-Bromodomain Complex with Scfv To Be Published.