Zinc in PDB 6g4t: The Crystal Structure of Uninhibited C183S/C217S Mutant of Human Ca VII

All present enzymatic activity of The Crystal Structure of Uninhibited C183S/C217S Mutant of Human Ca VII:
4.2.1.1;

The structure of The Crystal Structure of Uninhibited C183S/C217S Mutant of Human Ca VII, PDB code: 6g4t was solved by A.Di Fiore, K.D'ambrosio, G.De Simone, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	31.49 / 1.91
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	66.300, 89.380, 44.370, 90.00, 90.00, 90.00
R / Rfree (%)	19.6 / 24.4

The binding sites of Zinc atom in the The Crystal Structure of Uninhibited C183S/C217S Mutant of Human Ca VII (pdb code 6g4t). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the The Crystal Structure of Uninhibited C183S/C217S Mutant of Human Ca VII, PDB code: 6g4t:

Zinc binding site 1 out of 1 in the The Crystal Structure of Uninhibited C183S/C217S Mutant of Human Ca VII


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Crystal Structure of Uninhibited C183S/C217S Mutant of Human Ca VII within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:13.8 occ:1.00 NE2 A:HIS94 1.9 9.0 1.0 O A:HOH433 2.0 14.2 1.0 ND1 A:HIS119 2.0 10.6 1.0 NE2 A:HIS96 2.1 13.0 1.0 CD2 A:HIS94 2.9 8.4 1.0 CE1 A:HIS119 3.0 9.2 1.0 CD2 A:HIS96 3.0 13.1 1.0 CE1 A:HIS94 3.0 9.9 1.0 CE1 A:HIS96 3.1 13.8 1.0 CG A:HIS119 3.1 11.3 1.0 CB A:HIS119 3.5 10.8 1.0 O A:HOH453 3.7 23.6 1.0 OG1 A:THR199 3.9 13.9 1.0 O A:HOH518 3.9 20.8 1.0 OE1 A:GLU106 4.0 15.7 1.0 CG A:HIS94 4.1 9.3 1.0 ND1 A:HIS94 4.1 11.1 1.0 NE2 A:HIS119 4.2 8.7 1.0 CG A:HIS96 4.2 14.2 1.0 ND1 A:HIS96 4.2 12.0 1.0 CD2 A:HIS119 4.2 8.2 1.0 CD A:GLU106 4.8 15.4 1.0 O A:HOH555 4.9 29.4 1.0 CA A:HIS119 5.0 10.3 1.0

M.Buonanno, A.Di Fiore, E.Langella, K.D'ambrosio, C.T.Supuran, S.M.Monti, G.De Simone. The Crystal Structure of A Hca VII Variant Provides Insights Into the Molecular Determinants Responsible For Its Catalytic Behavior. Int J Mol Sci V. 19 2018.
ISSN: ESSN 1422-0067
PubMed: 29795045
DOI: 10.3390/IJMS19061571