Zinc in PDB 6fzs: Crystal Structure of SMAD5-MH1 Bound to the Ggcgc Site.

The structure of Crystal Structure of SMAD5-MH1 Bound to the Ggcgc Site., PDB code: 6fzs was solved by Z.Kaczmarska, J.A.Marquez, M.J.Macias, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.77 / 2.31
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	67.764, 73.374, 89.188, 90.00, 90.00, 90.00
R / Rfree (%)	19.3 / 24.1

The binding sites of Zinc atom in the Crystal Structure of SMAD5-MH1 Bound to the Ggcgc Site. (pdb code 6fzs). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of SMAD5-MH1 Bound to the Ggcgc Site., PDB code: 6fzs:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of SMAD5-MH1 Bound to the Ggcgc Site.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of SMAD5-MH1 Bound to the Ggcgc Site. within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:37.6 occ:1.00 ND1 A:HIS127 2.0 31.1 1.0 SG A:CYS122 2.3 39.5 1.0 SG A:CYS110 2.3 42.9 1.0 SG A:CYS65 2.4 39.4 1.0 CE1 A:HIS127 2.9 31.2 1.0 CG A:HIS127 3.1 30.6 1.0 CB A:CYS122 3.1 35.6 1.0 CB A:CYS110 3.3 40.2 1.0 CB A:CYS65 3.4 35.5 1.0 CB A:HIS127 3.5 27.7 1.0 CA A:CYS110 3.6 41.0 1.0 CA A:CYS65 3.7 36.1 1.0 NE2 A:HIS127 4.1 31.7 1.0 CD2 A:HIS127 4.2 31.4 1.0 N A:GLU111 4.3 41.3 1.0 C A:CYS110 4.4 45.7 1.0 N A:PHE112 4.5 35.9 1.0 N A:CYS65 4.5 39.0 1.0 CA A:CYS122 4.6 34.2 1.0 N A:CYS110 4.7 42.6 1.0 CB A:ASN124 4.8 28.5 1.0 C A:CYS65 4.9 38.8 1.0 N A:VAL66 4.9 35.6 1.0 CA A:HIS127 5.0 28.5 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of SMAD5-MH1 Bound to the Ggcgc Site.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of SMAD5-MH1 Bound to the Ggcgc Site. within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn201 b:43.4 occ:1.00 ND1 B:HIS127 1.9 39.3 1.0 SG B:CYS110 2.3 40.1 1.0 SG B:CYS122 2.4 44.9 1.0 SG B:CYS65 2.4 48.8 1.0 CE1 B:HIS127 2.9 39.3 1.0 CG B:HIS127 3.0 38.0 1.0 CB B:CYS122 3.2 41.1 1.0 CB B:CYS110 3.2 39.1 1.0 CB B:HIS127 3.4 35.5 1.0 CB B:CYS65 3.4 43.2 1.0 CA B:CYS110 3.6 41.8 1.0 CA B:CYS65 3.7 41.2 1.0 NE2 B:HIS127 4.0 39.6 1.0 CD2 B:HIS127 4.1 39.5 1.0 N B:GLU111 4.2 46.9 1.0 C B:CYS110 4.3 49.4 1.0 N B:CYS65 4.5 42.4 1.0 N B:PHE112 4.5 46.4 1.0 CA B:CYS122 4.7 39.4 1.0 N B:CYS110 4.7 45.2 1.0 CB B:ASN124 4.8 33.4 1.0 C B:CYS65 4.9 42.9 1.0 N B:VAL66 4.9 38.6 1.0 CA B:HIS127 4.9 36.0 1.0

L.Ruiz, Z.Kaczmarska, E.Aragon, J.Cordero, P.Martin Malpartida, R.Freier, J.A.Marquez, M.J.Macias. Recognition of the 5GC Dna Motif Is Conserved in Bmp and Tgf-Beta Activated Smad Proteins To Be Published.