Zinc in PDB 6fuw: Cryo-Em Structure of the Human CPSF160-WDR33-CPSF30 Complex Bound to the Pas Aauaaa Motif at 3.1 Angstrom Resolution

The binding sites of Zinc atom in the Cryo-Em Structure of the Human CPSF160-WDR33-CPSF30 Complex Bound to the Pas Aauaaa Motif at 3.1 Angstrom Resolution (pdb code 6fuw). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Cryo-Em Structure of the Human CPSF160-WDR33-CPSF30 Complex Bound to the Pas Aauaaa Motif at 3.1 Angstrom Resolution, PDB code: 6fuw:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Cryo-Em Structure of the Human CPSF160-WDR33-CPSF30 Complex Bound to the Pas Aauaaa Motif at 3.1 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of the Human CPSF160-WDR33-CPSF30 Complex Bound to the Pas Aauaaa Motif at 3.1 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn201 b:84.8 occ:1.00 NE2 C:HIS59 2.1 69.7 1.0 SG C:CYS41 2.5 69.8 1.0 SG C:CYS55 2.7 71.2 1.0 CD2 C:HIS59 2.7 69.7 1.0 SG C:CYS49 2.8 80.6 1.0 CB C:CYS41 3.0 69.8 1.0 CB C:CYS55 3.2 71.2 1.0 CE1 C:HIS59 3.3 69.7 1.0 CB C:PHE44 3.5 76.0 1.0 CB C:CYS49 3.8 80.6 1.0 CG C:HIS59 3.9 69.7 1.0 ND1 C:HIS59 4.2 69.7 1.0 CG C:PHE44 4.3 76.0 1.0 N C:PHE44 4.4 76.0 1.0 CA C:PHE44 4.5 76.0 1.0 O C:PHE57 4.5 61.9 1.0 CA C:CYS41 4.6 69.8 1.0 CA C:CYS49 4.6 80.6 1.0 CA C:CYS55 4.7 71.2 1.0 CD1 C:PHE44 4.8 76.0 1.0

Zinc binding site 2 out of 3 in the Cryo-Em Structure of the Human CPSF160-WDR33-CPSF30 Complex Bound to the Pas Aauaaa Motif at 3.1 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of the Human CPSF160-WDR33-CPSF30 Complex Bound to the Pas Aauaaa Motif at 3.1 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn202 b:51.9 occ:1.00 SG C:CYS76 2.3 41.5 1.0 SG C:CYS82 2.3 54.4 1.0 NE2 C:HIS86 2.3 44.8 1.0 SG C:CYS68 2.3 44.2 1.0 CB C:CYS82 2.8 54.4 1.0 CE1 C:HIS86 3.0 44.8 1.0 CD2 C:HIS86 3.3 44.8 1.0 CB C:CYS68 3.4 44.2 1.0 CB C:CYS76 3.5 41.5 1.0 ND1 C:HIS86 4.1 44.8 1.0 CG C:HIS86 4.3 44.8 1.0 O C:PHE84 4.3 48.5 1.0 CA C:CYS82 4.3 54.4 1.0 CB C:TRP71 4.6 39.6 1.0 N6 D:A2 4.6 49.3 1.0 CA C:CYS68 4.8 44.2 1.0 CA C:CYS76 4.9 41.5 1.0

Zinc binding site 3 out of 3 in the Cryo-Em Structure of the Human CPSF160-WDR33-CPSF30 Complex Bound to the Pas Aauaaa Motif at 3.1 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Cryo-Em Structure of the Human CPSF160-WDR33-CPSF30 Complex Bound to the Pas Aauaaa Motif at 3.1 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn203 b:83.2 occ:1.00 SG C:CYS96 2.3 58.2 1.0 SG C:CYS105 2.3 66.8 1.0 NE2 C:HIS114 2.3 60.1 1.0 SG C:CYS110 2.4 62.2 1.0 CB C:CYS105 2.9 66.8 1.0 CD2 C:HIS114 3.0 60.1 1.0 CE1 C:HIS114 3.1 60.1 1.0 CB C:CYS96 3.2 58.2 1.0 CB C:CYS110 3.4 62.2 1.0 CG C:HIS114 3.9 60.1 1.0 ND1 C:HIS114 3.9 60.1 1.0 CA C:CYS105 4.3 66.8 1.0 CB C:TYR99 4.3 59.8 1.0 O C:PHE112 4.5 54.9 1.0 CA C:CYS96 4.6 58.2 1.0 N6 D:A5 4.6 56.9 1.0 N C:TYR99 4.8 59.8 1.0 CA C:CYS110 4.8 62.2 1.0 CB C:PHE112 4.9 54.9 1.0

M.Clerici, M.Faini, L.M.Muckenfuss, R.Aebersold, M.Jinek. Structural Basis of Aauaaa Polyadenylation Signal Recognition By the Human Cpsf Complex. Nat. Struct. Mol. Biol. V. 25 135 2018.
ISSN: ESSN 1545-9985
PubMed: 29358758
DOI: 10.1038/S41594-017-0020-6